{"id":6611,"date":"2023-02-08T06:10:24","date_gmt":"2023-02-08T06:10:24","guid":{"rendered":"https:\/\/organonpro.com\/kr-kr\/?page_id=6611"},"modified":"2026-03-23T06:05:24","modified_gmt":"2026-03-23T06:05:24","slug":"cozaar_ssi","status":"publish","type":"page","link":"https:\/\/organonpro.com\/ko-kr\/cozaar_ssi\/","title":{"rendered":"\ucf54\uc790\ud328\ubc00\ub9ac \uc8fc\uc694 \uc548\uc804\uc131 \uc815\ubcf4"},"content":{"rendered":"\n<h2 class=\"wp-block-heading has-text-color\" id=\"h-selective-safety-information-\ucf54\uc790-\uc815-\ub85c\uc0ac\ub974\ud0c4\uce7c\ub968-50-100mg\" style=\"color:#0085cd\"><strong><strong>Selected Safety Information \ucf54\uc790<sup>\u00ae<\/sup>\uc815 (\ub85c\uc0ac\ub974\ud0c4\uce7c\ub968) 50, 100 mg<\/strong><\/strong><\/h2>\n\n\n\n<p><strong>[<\/strong><strong>\ud6a8\ub2a5\u00b7\ud6a8\uacfc<\/strong><strong>]<\/strong> 1. \uace0\ud608\uc555 2. \uc88c\uc2ec\uc2e4 \ube44\ub300\uac00 \uc788\ub294 \uace0\ud608\uc555 \ud658\uc790\uc5d0\uc11c\uc758 \ub1cc\uc878\uc911 \ubc1c\uc0dd \uc704\ud5d8\uc758 \uac10\uc18c&nbsp; 3. \uace0\ud608\uc555 \uce58\ub8cc\uc694\ubc95\uc73c\ub85c\uc11c, \uace0\ud608\uc555\uc744 \uac00\uc9c4 \uc81c2\ud615 \ub2f9\ub1e8\ubcd1 \ud658\uc790\uc758 \uc2e0\uc7a5\ubcd1 <strong>[<\/strong><strong>\uc6a9\ubc95\u00b7\uc6a9\ub7c9<\/strong>] 1. \uace0\ud608\uc555 \uc131\uc778: \ucd08\ud68c\ub7c9\uacfc \uc720\uc9c0\ub7c9\uc740 \ub85c\uc0ac\ub974\ud0c4\uce7c\ub968\uc73c\ub85c\uc11c 1\uc77c 1\ud68c 50 mg \uacbd\uad6c\ud22c\uc5ec \ud558\ub294 \uac83\uc774 \uad8c\uc7a5\ub41c\ub2e4. \uce58\ub8cc \uc2dc\uc791 \ud6c4 3\u223c6 \uc8fc \ud6c4\uc5d0 \ucd5c\ub300 \ud608\uc555 \uac15\ud558 \ud6a8\uacfc\uac00 \ub098\ud0c0\ub09c\ub2e4. \uce58\ub8cc \ud6a8\uacfc\uac00 \ubd88\ucda9\ubd84\ud55c \uacbd\uc6b0 \uac19\uc740 \uc6a9\ub7c9\uc744 1\uc77c 2\ud68c\ub85c \ubd84\ud560 \uacbd\uad6c\ud22c\uc5ec\ud558\uac70\ub098 \ud544\uc694\ud55c \uacbd\uc6b0 1\uc77c 1\ud68c 100 mg\uae4c\uc9c0 \uc99d\ub7c9\ud560 \uc218 \uc788\ub2e4. 2. \uc88c\uc2ec\uc2e4 \ube44\ub300\uac00 \uc788\ub294 \uace0\ud608\uc555 \ud658\uc790\uc5d0\uc11c\uc758 \ub1cc\uc878\uc911 \ubc1c\uc0dd \uc704\ud5d8\uc758 \uac10\uc18c: \uc131\uc778\uc5d0\uc11c \ucd08\ud68c\ub7c9\uc740 \ubcf4\ud1b5 \uc774 \uc57d\uc73c\ub85c\uc11c 1\uc77c 1\ud68c 50mg\uc774\ub2e4. \ud608\uc555\uc5d0 \ub530\ub77c \ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc 1\uc77c 12.5 mg\uc744 \ucd94\uac00\ud558\uace0\/\ud558\uac70\ub098 \uc774 \uc57d\uc758 \uc6a9\ub7c9\uc744 1\uc77c 1\ud68c 100 mg\uae4c\uc9c0 \uc99d\ub7c9\ud560 \uc218 \uc788\ub2e4. \ucd94\uac00\uc801\uc778 \ud608\uc555 \uac15\ud558\uac00 \ud544\uc694\ud55c \uacbd\uc6b0, \ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc\ub97c 1\uc77c 1\ud68c 25 mg\uae4c\uc9c0 \uc99d\ub7c9\ud560 \uc218 \uc788\ub2e4. 3. \uace0\ud608\uc555\uc744 \uac00\uc9c4 \uc81c2\ud615 \ub2f9\ub1e8\ubcd1 \ud658\uc790\uc758 \uc2e0\uc7a5\ubcd1:&nbsp; \uc131\uc778\uc5d0\uc11c \ubcf4\ud1b5 \uc774 \uc57d\uc73c\ub85c\uc11c 1\uc77c 1\ud68c 50 mg\uc774\ub2e4. \ud608\uc555\uc5d0 \ub530\ub77c 1\uc77c 1\ud68c 100 mg\uae4c\uc9c0 \uc99d\ub7c9\ud560 \uc218 \uc788\ub2e4. \uadf8\ub7ec\ub098 \uacfc\ub3c4\ud55c \ud608\uc555\uac15\ud558\uc758 \uc6b0\ub824\uac00 \uc788\ub294 \ud658\uc790\uc5d0\uac8c\ub294 \ucd08\ud68c\ub7c9\uc73c\ub85c 25 mg\uc774 \uad8c\uc7a5\ub41c\ub2e4. \uc774 \uc57d\uc740 \uc778\uc290\ub9b0, \uc0c1\uc6a9\ub418\ub294 \ud608\ub2f9\uac15\ud558\uc81c (\uc608, \uc124\ud3ec\ub2d0\uc6b0\ub808\uc544, \uae00\ub9ac\ud0c0\uc874, \uae00\ub8e8\ucf54\uc2dc\ub2e4\uc544\uc81c \uc5b5\uc81c\uc81c)\uc640 \ubcd1\uc6a9 \ud22c\uc5ec\ud560 \uc218 \uc788\ub2e4. <strong>[<\/strong><strong>\uacbd\uace0<\/strong><strong>]<\/strong> \uc784\ubd80\uc5d0\uac8c \ub808\ub2cc-\uc548\uc9c0\uc624\ud150\uc2e0-\uc54c\ub3c4\uc2a4\ud14c\ub860\uacc4 (RAAS)\uc5d0 \uc9c1\uc811 \uc791\uc6a9\ud558\ub294 \uc57d\ubb3c\ub4e4\uc758 \ud22c\uc5ec \uc2dc, \ud0dc\uc544 \ubc0f \uc2e0\uc0dd\uc544\uc5d0\uac8c \uc190\uc0c1 \ubc0f \uc0ac\ub9dd\uae4c\uc9c0\ub3c4 \uc77c\uc5b4\ub0a0 \uc218 \uc788\ub2e4. \uc591\uc218\uacfc\uc18c\uc99d\uc758 \ubc1c\uc0dd\uc740 \ud0dc\uc544\uc758 \ud3d0 \ud615\uc131 \uc800\ud558\uc99d \ubc0f \uace8\uaca9 \uae30\ud615\uacfc \uad00\ub828\uc774 \uc788\uc744 \uc218 \uc788\ub2e4. \uc2e0\uc0dd\uc544\uc5d0\uac8c \ub098\ud0c0\ub0a0 \uac00\ub2a5\uc131\uc774 \uc788\ub294 \ubd80\uc791\uc6a9\uc740 \ub450\uac1c\uace8 \ud615\uc131 \uc800\ud558\uc99d, \ubb34\ub1e8\uc99d, \uc800\ud608\uc555, \uc2e0\ubd80\uc804\uacfc \uc0ac\ub9dd \ub4f1\uc744 \ud3ec\ud568\ud55c\ub2e4. \uc784\uc2e0\uc774 \ud655\uc778\ub418\uba74 \uac00\ub2a5\ud55c \ube68\ub9ac \uc774 \uc57d\uc744 \uc911\ub2e8\ud574\uc57c \ud55c\ub2e4. <strong>[<\/strong><strong>\uae08\uae30<\/strong><strong>]<\/strong> 1) \uc774 \uc57d \ub610\ub294 \uc774 \uc57d\uc758 \uad6c\uc131\uc131\ubd84\uc5d0 \uacfc\ubbfc\ubc18\uc751 \ud658\uc790 2) \uc784\ubd80 \ub610\ub294 \uc784\uc2e0\ud558\uace0 \uc788\uc744 \uac00\ub2a5\uc131\uc774 \uc788\ub294 \uc5ec\uc131 3) \uc911\uc99d\uc758 \uac04\uc7a5\uc560 \ud658\uc790 4) \uc720\uc804\uc131 \ud608\uad00\ubd80\uc885 \ud658\uc790, ACE \uc5b5\uc81c\uc81c \ud639\uc740 \uc548\uc9c0\uc624\ud150\uc2e0\u2161\uc218\uc6a9\uccb4 \ucc28\ub2e8\uc81c \uce58\ub8cc \uc2dc \ud608\uad00\ubd80\uc885\uc758 \ubcd1\ub825\uc774 \uc788\ub294 \ud658\uc790 5) \uc6d0\ubc1c\uace0\uc54c\ub3c4\uc2a4\ud14c\ub860\uc99d \ud658\uc790 6) \uc774 \uc57d\uc740 \uc720\ub2f9\uc744 \ud568\uc720\ud558\uace0 \uc788\uc73c\ubbc0\ub85c, \uac08\ub77d\ud1a0\uc624\uc2a4 \ubd88\ub0b4\uc131 (galactose intolerance), Lapp \uc720\ub2f9\ubd84\ud574\ud6a8\uc18c \uacb0\ud54d\uc99d (Lapp lactase deficiency) \ub610\ub294 \ud3ec\ub3c4\ub2f9-\uac08\ub77d\ud1a0\uc624\uc2a4 \ud761\uc218\uc7a5\uc560 (glucose-galactose malabsorption) \ub4f1\uc758 \uc720\uc804\uc801\uc778 \ubb38\uc81c\uac00 \uc788\ub294 \ud658\uc790 7) \ub2f9\ub1e8\ubcd1\uc774\ub098 \uc911\ub4f1\ub3c4~\uc911\uc99d\uc758 \uc2e0\uc7a5\uc560 \ud658\uc790 (\uc0ac\uad6c\uccb4\uc5ec\uacfc\uc728 &lt;60 mL\/min\/1.73 m<sup>2<\/sup>)\uc5d0\uc11c \uc54c\ub9ac\uc2a4\ud0a4\ub80c \ud568\uc720\uc81c\uc81c\uc640\uc758 \ubcd1\uc6a9 <strong>[<\/strong><strong>\uc2e0\uc911\ud22c\uc5ec<\/strong><strong>]<\/strong> 1) \uace0\ub839\uc790 2) \uace0\uce7c\ub968\ud608\uc99d \ud658\uc790 \ud639\uc740 \ud608\uccad \uce7c\ub968\uce58\uac00 \ub192\uc544\uc9c0\uae30 \uc26c\uc6b4 \ud658\uc790 3) \uacbd\uc99d\u223c\uc911\ub4f1\ub3c4 \uac04\uc7a5\uc560 \ud658\uc790 4) \ub300\ub3d9\ub9e5\ud310 \ubc0f \uc2b9\ubaa8\ud310 \ud611\ucc29\uc99d \ud658\uc790 \ud639\uc740 \ud3d0\uc1c4\ube44\ub300\uc2ec\uadfc\ubcd1 \ud658\uc790 5) \ud5c8\ud608 \uc2ec\uc7a5\ubcd1, \ud5c8\ud608 \uc2ec\uc7a5\ud608\uad00 \uc9c8\ud658, \ub1cc\ud608\uad00 \uc7a5\uc560 \ud658\uc790 (\uacfc\ub3c4\ud55c \ud608\uc555\uac15\ud558\ub294 \uc2ec\uadfc\uacbd\uc0c9\uc774\ub098 \ub1cc\ud608\ub958 \ubd80\uc804\uc73c\ub85c \uc778\ud55c \ub1cc\uc878\uc911\uc744 \uc77c\uc73c\ud0ac \uc218 \uc788\ub2e4.) 6) \ud608\uad00 \ub0b4 \uc720\ud6a8\ud608\uc561\ub7c9 \uac10\uc18c\ud658\uc790 (\uc608, \uc774\ub1e8\uc81c \ud22c\uc5ec \uc911\uc778 \ud658\uc790, \uc5c4\uaca9\ud55c \uc5fc\ubd84\uc81c\ud55c \ud658\uc790, \ud608\uc561\ud22c\uc11d \uc911\uc778 \ud658\uc790, \uc124\uc0ac \ud639\uc740 \uad6c\ud1a0 \ud658\uc790) 7) \uc591\uce21\uc131 \ud639\uc740 \ud3b8\uce21\uc131 \uc2e0\ub3d9\ub9e5 \ud611\ucc29\uc99d\uc774 \uc788\ub294 \ud658\uc790 8) \uc911\uc99d\uc758 \uc2e0\uc7a5\uc560 \ud658\uc790 9) \ub808\ub2cc-\uc548\uc9c0\uc624\ud150\uc2e0-\uc54c\ub3c4\uc2a4\ud14c\ub860\uacc4 (RAAS)\uc758 \uc774\uc911\ucc28\ub2e8 : \uc548\uc9c0\uc624\ud150\uc2e0 \uc218\uc6a9\uccb4 \ucc28\ub2e8\uc81c (ARB), ACE \uc5b5\uc81c\uc81c, \ub610\ub294 \uc54c\ub9ac\uc2a4\ud0a4\ub80c \ub4f1 \ub808\ub2cc-\uc548\uc9c0\uc624\ud150\uc2e0-\uc54c\ub3c4\uc2a4\ud14c\ub860\uacc4 (RAAS)\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \ub2e4\ub978 \uc57d\uc81c\uc640\uc758 \ubcd1\uc6a9\uc740 \uad8c\uc7a5\ub418\uc9c0 \uc54a\ub294\ub2e4.<strong> [<\/strong><strong>\uc774\uc0c1\ubc18\uc751<\/strong><strong>]<\/strong> 1) \uc774 \uc57d\uc740 \ubcf8\ud0dc\uc131\uace0\ud608\uc555 \uc131\uc778\ud658\uc790 3,300\uba85 \uc774\uc0c1\uc744 \ud3ec\ud568\ud558\uc5ec \uc804\uccb4 4,058\uba85\uc758 \uc784\uc0c1\uc2dc\ud5d8 \ub300\uc0c1\uc790\uc5d0\uc11c \uc548\uc804\uc131\uc774 \ud3c9\uac00\ub418\uc5c8\ub2e4. 1,200\uba85 \uc774\uc0c1\uc758 \ud658\uc790\ub294 6\uac1c\uc6d4 \uc774\uc0c1 \ud22c\uc57d \ubc1b\uc558\uace0, 800\uba85 \uc774\uc0c1\uc758 \ud658\uc790\ub294 1\ub144 \uc774\uc0c1 \ud22c\uc57d \ubc1b\uc558\ub2e4. \uc77c\ubc18\uc801\uc73c\ub85c \uc774 \uc57d\uc740 \ub0b4\uc57d\uc131\uc774 \uc6b0\uc218\ud558\uc600\ub2e4. \uc804\uccb4\uc801\uc778 \uc774\uc0c1\ubc18\uc751 \ubc1c\ud604\uc728\uc740 \uc2dc\ud5d8\uad70\uacfc \ub300\uc870\uad70 \uc0ac\uc774\uc5d0 \ud070 \ucc28\uc774\uac00 \uc5c6\uc5c8\ub2e4. \ub300\uc870\uc784\uc0c1\uc2dc\ud5d8\uc5d0\uc11c \uc784\uc0c1\uc801 \uc774\uc0c1\ubc18\uc751\uc73c\ub85c \uc778\ud558\uc5ec \ud22c\uc5ec\ub97c \uc911\ub2e8\ud55c \uacbd\uc6b0\ub294 \ub85c\uc0ac\ub974\ud0c4\uad70\uc758 \uacbd\uc6b0 2.3%\uc600\uc73c\uba70, \uc704\uc57d\uad70\uc758 \uacbd\uc6b0 3.7%\uc600\ub2e4. 2) \uace0\ud608\uc555\uc744 \uac00\uc9c4 \uc81c 2\ud615 \ub2f9\ub1e8\ubcd1 \ud658\uc790\uc758 \uc2e0\uc7a5\ubcd1. \uc548\uc9c0\uc624\ud150\uc2e0\u2161\uc218\uc6a9\uccb4 \ucc28\ub2e8\uc81c\uc778 \uc774 \uc57d\uc5d0 \uc758\ud55c \uc778\uc290\ub9b0-\ube44\uc758\uc874\uc131 \ub2f9\ub1e8\ubcd1\uc758 \ud3c9\uac00\ud56d\ubaa9\uc758 \uac10\uc18c\ub97c \uc5f0\uad6c\ud55c \uc2dc\ud5d8(Reduction of Endpoints in NIDDM with the Angiotensin II Receptor Antagonist Losartan, RENAAL study)\uc5d0\uc11c 1,513 \uba85\uc758 \ud658\uc790\uac00 \uc774 \uc57d \ud639\uc740 \uc704\uc57d\uc744 \ud22c\uc5ec \ubc1b\uc558\uc73c\uba70, \uc0c1\uae30 \uc784\uc0c1\uc2dc\ud5d8\uc5d0\uc11c \ubcf4\uace0\ub41c \uc774\uc0c1\ubc18\uc751\uc758 \ubc1c\uc0dd\ub960\uc740 \ub450 \uad70\uac04 \ucc28\uc774\uac00 \uc5c6\uc5c8\ub2e4. \uc774\uc0c1\ubc18\uc751\uc73c\ub85c \uc778\ud558\uc5ec \ud22c\uc5ec\ub97c \uc911\ub2e8\ud55c \ube44\uc728\ub3c4 \uc720\uc0ac\ud558\uc5ec (\uc2e4\ud5d8\uad70 19 %, \uc704\uc57d\uad70 24 %) \uc774 \uc57d\uc740 \uc77c\ubc18\uc801\uc73c\ub85c \ub0b4\uc57d\uc131\uc774 \uc6b0\uc218\ud558\uc600\ub2e4. 3) \uc2dc\ud310 \ud6c4 \ucd94\uac00 \ubcf4\uace0 (1) \uacfc\ubbfc\ubc18\uc751 : \ud608\uad00\ubd80\uc885(\uae30\ub3c4 \ud3d0\uc1c4\ub97c \uc57c\uae30\ud560 \uc218 \uc788\ub294 \ud6c4\ub450\/\uc131\ubb38\uc758 \ud33d\uc724, \uc5bc\uad74\/\uc785\uc220\/\uc778\ub450\/\ud600\uc758 \ud33d\uc724)\uc774 \uc774 \uc57d\uc744 \ud22c\uc5ec\ubc1b\uc740 \ud658\uc790\uc5d0\uc11c \ub4dc\ubb3c\uac8c \ubcf4\uace0\ub418\uc5c8\uc73c\uba70, \uc774\ub4e4 \uc774\uc0c1\ubc18\uc751\uc744 \ubcf4\uc778 \ud658\uc790 \uc911 \uc77c\ubd80\ub294 \uc774\uc804\uc5d0 ACE \uc5b5\uc81c\uc81c\ub4f1\uc758 \ub2e4\ub978 \uc57d\ubb3c\uc5d0 \ub300\ud574\uc11c\ub3c4 \ud608\uad00\ubd80\uc885\uc744 \uacbd\ud5d8\ud55c \uc801\uc774 \uc788\uc5c8\ub2e4. \uc7a5 \ud608\uad00 \ubd80\uc885\uc740 \ub85c\uc0ac\ub974\ud0c4\uc744 \ube44\ub86f\ud55c \uc548\uc9c0\uc624\ud150\uc2e0 II \uc218\uc6a9\uccb4 \ucc28\ub2e8\uc81c\ub85c \uce58\ub8cc\ubc1b\uc740 \ud658\uc790\uc5d0\uc11c \ubcf4\uace0\ub41c \ubc14 \uc788\ub2e4. \ud608\uad00\uc5fc(Henoch- Sch\u00f6nlein \uc790\ubc18\ubcd1)\uc774 \ubcf4\uace0\ub41c \uc801\uc774 \uc788\ub2e4. \ub610\ud55c \uc544\ub098\ud544\ub77d\uc2dc\uc2a4\uc591 \uc99d\ud6c4\uad70(\ubd88\ucf8c\uac10, \uad6c\uac15 \uc774\uc0c1 \ub290\ub08c, \ubc1c\ud55c, \ub450\ub4dc\ub7ec\uae30, \ud638\ud761 \uace4\ub780, \uc804\uc2e0 \ud64d\uc870, \ubd80\uc885 \ub4f1)\uc774 \uc99d\uc0c1\uc73c\ub85c \ub098\ud0c0\ub0a0 \uc218 \uc788\uc73c\ubbc0\ub85c \uad00\ucc30\uc744 \ucda9\ubd84\ud788 \ud55c\ub2e4. <strong>[<\/strong><strong>\uc77c\ubc18\uc801<\/strong><strong> <\/strong><strong>\uc8fc\uc758<\/strong><strong>] <\/strong>1) \uac04\uacbd\ubcc0\uc99d \ud658\uc790\uc758 \ud608\uc7a5 \ub85c\uc0ac\ub974\ud0c4 \ub18d\ub3c4\uac00 \ud604\uc800\ud788 \uc0c1\uc2b9\ub418\uc5c8\ub2e4\ub294 \ubcf4\uace0\uac00 \uc788\uc73c\ubbc0\ub85c, \uac04\uae30\ub2a5 \uc7a5\uc560\uac00 \uc788\ub294 \ud658\uc790\ub4e4\uc740 \uc18c\ub7c9 \ud22c\uc5ec\ub97c \uace0\ub824\ud55c\ub2e4. 2) \uc548\uc9c0\uc624\ud150\uc2e0\u2161\uc218\uc6a9\uccb4 \ucc28\ub2e8\uc81c \ud22c\uc5ec \uc911 \ub4dc\ubb3c\uac8c \uac04\uc5fc \ub4f1\uc758 \uc2ec\uac01\ud55c \uac04\uc7a5\uc560\uac00 \ub098\ud0c0\ub0ac\ub2e4\ub294 \ubcf4\uace0\uac00 \uc788\ub2e4. 3) \ub808\ub2cc-\uc548\uc9c0\uc624\ud150\uc2e0-\uc54c\ub3c4\uc2a4\ud14c\ub860\uacc4\uc5d0 \ub300\ud55c \uc601\ud5a5\uc758 \uacb0\uacfc, \uc2e0\ubd80\uc804\uc744 \ud3ec\ud568\ud55c \uc2e0\uae30\ub2a5\uc758 \ubcc0\ud654\uac00 \ubcf4\uace0\ub418\uc5c8\ub2e4. \uc774\ub7ec\ud55c \uc2e0\uae30\ub2a5\uc758 \ubcc0\ud654\ub294 \ud22c\uc5ec \uc911\ub2e8 \uc2dc \uc815\uc0c1\uc73c\ub85c \ud68c\ubcf5\ub418\uc5c8\ub2e4. \uc2e0\uae30\ub2a5\uc774 \ub808\ub2cc-\uc548\uc9c0\uc624\ud150\uc2e0-\uc54c\ub3c4\uc2a4\ud14c\ub860\uacc4\uc5d0 \uc758\uc874\uc801\uc778 \ud658\uc790\uc758 \uacbd\uc6b0(\uc608, \uc911\uc99d\uc758 \uc6b8\ud608\uc2ec\ubd80\uc804 \ud658\uc790), ACE \uc5b5\uc81c\uc81c\ub97c \ud22c\uc5ec\ud558\uc600\uc744 \ub54c, \ube48\ub1e8 \ubc0f\/\ud639\uc740 \uc9c4\ud589\uc131 \uc9c8\uc18c\ud608\uc99d\uc774 \ubcf4\uace0\ub418\uc5c8\uc73c\uba70, (\ub4dc\ubb3c\uac8c) \uae09\uc131 \uc2e0\ubd80\uc804 \ubc0f\/\ud639\uc740 \uc0ac\ub9dd\uc774 \ubcf4\uace0\ub418\uc5c8\ub2e4. \uc720\uc0ac\ud55c \uacb0\uacfc\uac00 \uc774 \uc57d\uc744 \ud22c\uc5ec\ud55c \ud658\uc790\uc5d0\uc11c\ub3c4 \ubcf4\uace0\ub418\uc5c8\ub2e4. ACE \uc5b5\uc81c\uc81c\uac00 \uc591\uce21\uc131 \ud639\uc740 \ud3b8\uce21\uc131 \uc2e0\ub3d9\ub9e5 \ud611\ucc29\uc99d\uc744 \uac16\ub294 \ud658\uc790\ub4e4\uc758 \ud608\uc911 \uc694\uc18c\uc640 \ud608\uccad \ud06c\ub808\uc544\ud2f0\ub2cc\uce58\ub97c \uc0c1\uc2b9\uc2dc\ucf30\ub2e4\ub294 \ubcf4\uace0\uac00 \uc788\ub2e4. \uc774 \uc57d\uc744 \ud22c\uc5ec\ud55c \ud658\uc790\uc5d0\uc11c\ub3c4 \uc720\uc0ac\ud55c \uacb0\uacfc\uac00 \ubcf4\uace0\ub418\uc5c8\ub2e4. \uc774\ub294 \ud22c\uc5ec \uc911\ub2e8 \uc2dc \ud68c\ubcf5\ub418\uc5c8\ub2e4. \ub610\ud55c \uc774\ub4e4 \ud658\uc790\uad70\uc5d0\uc11c \uc2e0\ud608\ub958\ub7c9\uc758 \uac10\uc18c\uc640 \uc0ac\uad6c\uccb4 \uc5ec\uacfc\uc555\uc758 \uc800\ud558\uc5d0 \uc758\ud574 \uae09\uc18d\ud788 \uc2e0\uae30\ub2a5\uc744 \uc545\ud654\uc2dc\ud0ac \uc6b0\ub824\uac00 \uc788\uace0, \uc800\ud608\uc555\uc744 \uc77c\uc73c\ud0ac \uc218 \uc788\ub2e4. \uc911\uc99d\uc758 \uc2e0\uc7a5\uc560\ud658\uc790\uc5d0\uac8c \uc774 \uc57d \ud22c\uc5ec\uc2dc \uace0\uce7c\ub968\ud608\uc99d\uc774 \ub098\ud0c0\ub098\uae30 \uc27d\ub2e4. \ub610\ud55c \uc2e0\uae30\ub2a5\uc758 \uc545\ud654\uac00 \uc77c\uc5b4\ub0a0 \uc6b0\ub824\uac00 \uc788\uc73c\ubbc0\ub85c \ud608\uccad\ud06c\ub808\uc544\ud2f0\ub2cc\uc774 2.5 mg\/dL \uc774\uc0c1\uc758 \uacbd\uc6b0\uc5d0\ub294 \ud22c\uc5ec\ub7c9\uc744 \uc904\uc774\ub294 \ub4f1 \uc2e0\uc911\ud788 \ud22c\uc5ec\ud55c\ub2e4. 4) \uc804\ud574\uc9c8 \ubd88\uade0\ud615\uc740 \ub2f9\ub1e8\ubcd1 \uc720\ubb34\uc5d0 \uc0c1\uad00\uc5c6\uc774 \uc2e0\uc7a5\uc560 \ud658\uc790\uc5d0\uc11c \ube48\ubc88\ud558\uac8c \ubc1c\uc0dd\ud558\ubbc0\ub85c \ubc18\ub4dc\uc2dc \uc54c\ub824\uc57c \ud55c\ub2e4. \ub2e8\ubc31\ub1e8\ub97c \ub3d9\ubc18\ud55c \uc81c 2\ud615 \ub2f9\ub1e8\ubcd1 \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \uc2e4\uc2dc\ub41c \uc784\uc0c1\uc2dc\ud5d8\uc5d0\uc11c \uace0\uce7c\ub968\ud608\uc99d\uc774 \uc704\uc57d\uad70\uc5d0 \ube44\ud558\uc5ec \uc2e4\ud5d8\uad70\uc5d0\uc11c \ub354 \ub9ce\uc774 \ubcf4\uace0\ub418\uc5c8\ub2e4. \uadf8\ub7ec\ub098 \uace0\uce7c\ub968\ud608\uc99d\uc73c\ub85c \uc778\ud558\uc5ec \ud22c\uc5ec\ub97c \uc911\ub2e8\ud55c \ud658\uc790\ub294 \ub4dc\ubb3c\uc5c8\ub2e4. 5) \uace0\uce7c\ub968\ud608\uc99d (\ud608\uccad \uce7c\ub968 &gt; 5.5 mmol\/L)\uc774 1.5 %\uc758 \ud658\uc790\uc5d0\uac8c\uc11c \ubc1c\uc0dd\ud558\uc600\uc73c\ub098, \uc57d\ubb3c \ud22c\uc5ec\ub97c \uc911\ub2e8\ud560 \uc815\ub3c4\ub294 \uc544\ub2c8\uc5c8\ub2e4. \uace0\ub839\uc790\uc640 \uc2e0\uc7a5\uc7a5\uc560 \ud658\uc790\ub4e4\uc740 \ud608\uccad \uce7c\ub968\uc744 \uac80\uc0ac \ubc1b\uc544\uc57c \ud55c\ub2e4. \ud2b9\ud788 \uc2ec\ubd80\uc804 \ud658\uc790\uc640 \ud06c\ub808\uc544\ud2f0\ub2cc\uccad\uc18c\uc728\uc774 30 \u223c50 mL\/min\uc778 \ud658\uc790\uc758 \uacbd\uc6b0, \ud608\uc7a5 \uce7c\ub968 \ub18d\ub3c4 \ubc0f \ud06c\ub808\uc544\ud2f0\ub2cc\uccad\uc18c\uc728\uc744 \uc8fc\uc758\uae4a\uac8c \uad00\ucc30\ud574\uc57c \ud55c\ub2e4. \uc2e0\uc7a5\uc560, \ub2f9\ub1e8\ubcd1 \ub4f1\uc5d0 \uc758\ud574 \ud608\uccad \uce7c\ub968\uce58\uac00 \ub192\uc544\uc9c0\uae30 \uc26c\uc6b4 \ud658\uc790\uc5d0\uc11c\ub294 \uace0\uce7c\ub968\ud608\uc99d\uc774 \ubc1c\ud604\ub420 \ud655\ub960\uc774 \ub354 \ud06c\ubbc0\ub85c \ud608\uccad \uce7c\ub968\uce58\uc5d0 \uc8fc\uc758\ud55c\ub2e4. \ub610\ud55c \uace0\uce7c\ub968\ud608\uc99d \ud658\uc790\uc5d0\uc11c \uace0\uce7c\ub968\ud608\uc99d\uc744 \uc545\ud654\uc2dc\ud0ac \uc6b0\ub824\uac00 \uc788\uc73c\ubbc0\ub85c \uce58\ub8cc \ubd88\uac00\ud53c\ud558\ub2e4\uace0 \ud310\ub2e8\ub418\ub294 \uacbd\uc6b0\ub97c \uc81c\uc678\ud558\uace0\ub294 \uc0ac\uc6a9\uc744 \ud53c\ud55c\ub2e4. \ud608\uccad \uce7c\ub968 \ub18d\ub3c4\ub97c \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\ub294 \ub2e4\ub978 \uc57d\ubb3c\uacfc\uc758 \ubcd1\uc6a9\uc740 \uace0\uce7c\ub968\ud608\uc99d\uc744 \uc77c\uc73c\ud0ac \uc218 \uc788\ub2e4. \uc774 \uc57d\uc740 \uce7c\ub968\ubcf4\uc874\uc774\ub1e8\uc81c\ub098 \uce7c\ub968\ubcf4\ucda9\uc81c, \uce7c\ub968\uc744 \ud3ec\ud568\ud55c \uc5fc\ubd84 \ub300\uc6a9\uc81c, \ub610\ub294 \ud608\uccad \uce7c\ub968 \ub18d\ub3c4\ub97c \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\ub294 \ub2e4\ub978 \uc57d\ubb3c\uacfc\uc758 \ubcd1\uc6a9\ud22c\uc5ec\ub294 \uad8c\uc7a5\ub418\uc9c0 \uc54a\ub294\ub2e4. 6) \uc774 \uc57d\uc758 \ud22c\uc5ec\uc5d0 \uc758\ud574(\ud2b9\ud788, \uce58\ub8cc \uc2dc\uc791, \uc6a9\ub7c9 \uc99d\ub7c9 \uc2dc) \uc77c\uacfc\uc131\uc758 \ud608\uc555\uac15\ud558(\uc1fc\ud06c\uc99d\uc0c1, \uc758\uc2dd\uc0c1\uc2e4, \ud638\ud761\uace4\ub780 \ub4f1\uc744 \ub3d9\ubc18)\ub97c \uc77c\uc73c\ud0ac \uc218 \uc788\uc73c\ubbc0\ub85c \uadf8\ub7ec\ud55c \uacbd\uc6b0\uc5d0\ub294 \ud22c\uc5ec\ub97c \uc911\uc9c0\ud558\uace0 \uc801\uc808\ud55c \ucc98\uce58\ub97c \ud55c\ub2e4. \ud2b9\ud788, \ud608\uad00 \ub0b4 \uc720\ud6a8 \ud608\uc561\ub7c9 \uac10\uc18c \ud658\uc790\uc5d0 \ud22c\uc5ec \uc2dc \uc18c\ub7c9\uc73c\ub85c \uac1c\uc2dc\ud558\uace0 \uc99d\ub7c9 \uc2dc \ud658\uc790\uc758 \uc0c1\ud0dc\ub97c \ucda9\ubd84\ud788 \uad00\ucc30\ud558\uc5ec\uc57c \ud55c\ub2e4. \ub610\ud55c \uc774 \uc57d \ud22c\uc5ec \uc911\uc5d0 \uc815\uae30\uc801\uc73c\ub85c \ud608\uc555 \ubaa8\ub2c8\ud130\ub9c1\uc744 \uc2e4\uc2dc\ud560 \uac83\uc774 \uad8c\uc7a5\ub41c\ub2e4. 7) \uc2e0\ubd80\uc804 \uc720\ubb34\uc640 \uc0c1\uad00\uc5c6\uc774 \uc2ec\ubd80\uc804 \ud658\uc790\uc5d0\uc11c \uc911\uc99d\uc758 \uc800\ud608\uc555\uc774\ub098 \uc2e0\ubd80\uc804(\uc8fc\ub85c \uae09\uc131)\uc744 \uc77c\uc73c\ud0ac \uc6b0\ub824\uac00 \uc788\ub2e4. \uc911\uc99d\uc758 \uc2e0\ubd80\uc804\uc744 \uac00\uc9c4 \uc2ec\ubd80\uc804 \ud658\uc790, \uc911\uc99d\uc758 \uc2ec\ubd80\uc804 \ud658\uc790(NYHA class \u2163), \uc2ec\ubd80\uc804 \ubc0f \uc0dd\uba85\uc744 \uc704\ud611\ud558\ub294 \uc2ec\ubd80\uc815\ub9e5\uc744 \uac00\uc9c4 \ud658\uc790\ub4e4\uc5d0\uac8c \uc774 \uc57d\uc744 \ud22c\uc5ec\ud55c \uc784\uc0c1\uacbd\ud5d8\uc740 \uac70\uc758 \uc5c6\uc73c\ubbc0\ub85c, \uc774\ub7ec\ud55c \ud658\uc790\ub4e4\uc5d0\uac8c \uc774 \uc57d \ud22c\uc5ec \uc2dc \uc8fc\uc758\ud574\uc57c \ud55c\ub2e4. 8) \uace0\ud608\uc555\uacfc \ub2e8\ubc31\ub1e8\ub97c \ub3d9\ubc18\ud558\ub294 2\ud615 \ub2f9\ub1e8\ubcd1\uc5d0\uc11c\uc758 \ub2f9\ub1e8\ubcd1 \uc2e0\uc99d\uc5d0 \ub300\ud574 \uc774 \uc57d\uc744 \ud22c\uc5ec\ud558\ub294 \uacbd\uc6b0, \ud608\uccad \ud06c\ub808\uc544\ud2f0\ub2cc\uc774 \uc774\uc804 \uac80\uc0ac\uce58\uc640 \ube44\uad50\ud558\uc5ec 30 % (\ub610\ub294 1 mg\/dL)\uc774\uc0c1 \uc99d\uac00\ud558\ub294 \uacbd\uc6b0 \ubc0f \uc2e0\uae30\ub2a5\uc7a5\uc560\uc758 \uc9c4\uc804\uc18d\ub3c4\uac00 \uac00\uc18d\ub418\ub294 \uacbd\uc6b0\uc5d0\ub294 \uac10\ub7c9 \ud639\uc740 \ud22c\uc5ec\uc911\uc9c0\ub97c \uace0\ub824\ud55c\ub2e4. 9)\uc218\uc220 \uc804 24 \uc2dc\uac04\uc740 \ud22c\uc5ec\ud558\uc9c0 \uc54a\ub294 \uac83\uc774 \ubc14\ub78c\uc9c1\ud558\ub2e4. 10) 2\ud615 \ub2f9\ub1e8\ubcd1\uc5d0\uc11c\uc758 \ub2f9\ub1e8\ubcd1 \uc2e0\uc99d \ud658\uc790\ub294 \ube48\ud608\uc774 \ub098\ud0c0\ub098\uae30 \uc26c\uc6b0\ubbc0\ub85c \uc774 \uc57d\uc758 \ud22c\uc5ec \uc911\uc5d0\ub294 \uc815\uae30\uc801\uc73c\ub85c \ud608\uc561\uac80\uc0ac\ub97c \uc2e4\uc2dc\ud558\ub294 \ub4f1 \uad00\ucc30\uc744 \ucda9\ubd84\ud788 \ud558\uace0 \uc774\uc0c1\uc774 \uc778\uc815\ub418\ub294 \uacbd\uc6b0\uc5d0\ub294 \ube48\ud608\uc758 \uc6d0\uc778\uc744 \uace0\ub824\ud558\uc5ec \uc801\uc808\ud55c \ucc98\uce58\ub97c \ud55c\ub2e4. 11) \uc774 \uc57d\uc740 \uc2e0\uc7a5\uc774\uc2dd\ud658\uc790\uc5d0 \ub300\ud55c \uc784\uc0c1\uacbd\ud5d8\uc774 \uc5c6\ub2e4. 12) \uc6d0\ubc1c\uace0\uc54c\ub3c4\uc2a4\ud14c\ub860\uc99d\uc744 \uac00\uc9c4 \ud658\uc790\ub4e4\uc758 \uacbd\uc6b0 \uc77c\ubc18\uc801\uc73c\ub85c \ub808\ub2cc-\uc548\uc9c0\uc624\ud150\uc2e0-\uc54c\ub3c4\uc2a4\ud14c\ub860\uacc4\ub97c \uc5b5\uc81c\ud558\ub294 \uace0\ud608\uc555 \uce58\ub8cc\uc81c\uc5d0 \ubc18\uc751\ud558\uc9c0 \uc54a\uc73c\ubbc0\ub85c \uc774 \uc57d\uc744 \ud22c\uc5ec\ud574\uc11c\ub294 \uc548\ub41c\ub2e4. 13) \ud608\uc555\uac15\ud558\uc791\uc6a9\uc5d0 \uc758\ud574 \uc5b4\uc9c0\ub7fc, \ud718\uccad\uac70\ub9bc\uc774 \ub098\ud0c0\ub0a0 \uc218 \uc788\uc73c\ubbc0\ub85c \uace0\uc18c\uc791\uc5c5, \ucc28\ub7c9\uc6b4\uc804 \ubc0f \uae30\uacc4\uc870\uc791 \uc2dc \uc8fc\uc758\ub97c \uae30\uc6b8\uc5ec\uc57c \ud55c\ub2e4. \ud2b9\ud788 \uce58\ub8cc \ucd08\uae30\ub098 \uc6a9\ub7c9 \uc99d\ub7c9 \uc2dc \uc8fc\uc758\ud55c\ub2e4. 14) \uc7a5 \ud608\uad00 \ubd80\uc885\uc774 \uc548\uc9c0\uc624\ud150\uc2e0 \u2161 \uc218\uc6a9\uccb4 \ucc28\ub2e8\uc81c\ub97c \ud22c\uc5ec\ubc1b\uc740 \ud658\uc790\uc5d0\uc11c \ubcf4\uace0\ub418\uc5c8\ub2e4. \ubcf5\ud1b5, \uba54\uc2a4\uaebc\uc6c0, \uad6c\ud1a0 \ubc0f \uc124\uc0ac\uac00 \ubcf4\uace0\ub418\uc5c8\uace0, \ud22c\uc5ec \uc911\ub2e8 \ud6c4 \uc99d\uc0c1\uc774 \uc644\ud654\ub418\uc5c8\ub2e4. \uc7a5 \ud608\uad00 \ubd80\uc885\uc774 \ud655\uc778\ub418\uba74 \ud22c\uc5ec\ub97c \uc911\ub2e8\ud558\uace0 \uc99d\uc0c1\uc774 \uc644\ud654\ub420 \ub54c\uae4c\uc9c0 \uc801\uc808\ud788 \ubaa8\ub2c8\ud130\ub9c1 \ud574\uc57c \ud55c\ub2e4.&nbsp; <strong>[<\/strong><strong>\uc0c1\ud638\uc791\uc6a9<\/strong><strong>]<\/strong> 1) \ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc, \ub514\uace1\uc2e0, \uc640\ub974\ud30c\ub9b0, \uc2dc\uba54\ud2f0\ub518, \ud398\ub178\ubc14\ub974\ube44\ud0c8 \ub4f1\uc758 \uc57d\ubb3c\uacfc \uc784\uc0c1 \uc57d\ubb3c \ub3d9\ub825\ud559 \uc2dc\ud5d8 \uacb0\uacfc \uc784\uc0c1\uc801\uc73c\ub85c \uc720\uc758\ud55c \uc57d\ubb3c\uc0c1\ud638\uc791\uc6a9\uc740 \ubc1c\uacac\ub418\uc9c0 \uc54a\uc558\ub2e4 (\uc57d\ubb3c \ub300\uc0ac \uc720\ub3c4\uc81c\uc778 \ud398\ub178\ubc14\ub974\ube44\ud0c8\uc740 \uc774 \uc57d\uacfc \uc774 \uc57d\uc758 \ud65c\uc131\ub300\uc0ac\uccb4\uc758 AUC\ub97c 20% \uac10\uc18c\uc2dc\ucf30\ub2e4. \ud6a8\uc18c \uc5b5\uc81c\uc81c\uc778 \uc2dc\uba54\ud2f0\ub518\uc740 \ub85c\uc0ac\ub974\ud0c4\uc758 AUC \ub97c 18 % \uc99d\uac00\uc2dc\ucf30\uc73c\ub098, \ud65c\uc131\ub300\uc0ac\uccb4\uc5d0\ub294 \uc601\ud5a5\uc774 \uc5c6\uc5c8\ub2e4. \uc774\ub7ec\ud55c \ubcc0\ud654\ub294 \uc784\uc0c1\uc801\uc73c\ub85c \uc720\uc758\ud558\uc9c0 \uc54a\uc740 \uac83\uc73c\ub85c \ud310\ub2e8\ub41c\ub2e4.) \uc57d\ubb3c \ub300\uc0ac \uc720\ub3c4\uc81c\uc778 \ub9ac\ud31c\ud540\uc740 \ub85c\uc0ac\ub974\ud0c4\uacfc \ud65c\uc131\ub300\uc0ac\uccb4\uc758 \ub18d\ub3c4\ub97c 40 % \uac10\uc18c\uc2dc\ucf30\ub2e4. \uc0ac\ub78c\uc5d0\uc11c 2\uac1c\uc758 CYP3A4 \uc5b5\uc81c\uc81c\uac00 \uc5f0\uad6c\ub418\uc5c8\ub2e4. \ucf00\ud1a0\ucf54\ub098\uc878\uc740 \uc815\ub9e5\ud22c\uc5ec\ud55c \uc774 \uc57d\uc774 \ud65c\uc131 \ub300\uc0ac\ubb3c\ub85c \uc804\ud658\ub418\ub294\ub370 \uc601\ud5a5\uc744 \ubbf8\uce58\uc9c0 \uc54a\uc558\uc73c\uba70 \uc5d0\ub9ac\ud2b8\ub85c\ub9c8\uc774\uc2e0\uc740 \uc774 \uc57d\uc758 \uacbd\uad6c\ud22c\uc5ec \ud6c4 \uc784\uc0c1\uc801\uc73c\ub85c \uc720\uc758\ud55c \uc601\ud5a5\uc744 \uc8fc\uc9c0 \uc54a\uc558\ub2e4. CYP2C9\uc758 \uc5b5\uc81c\uc81c\uc778 \ud50c\ub8e8\ucf54\ub098\uc878\uc740 \ud65c\uc131\ub300\uc0ac\uccb4\uc758 \ub18d\ub3c4\ub97c \uc57d 50% \uac10\uc18c\uc2dc\ud0a4\uace0 \ub85c\uc0ac\ub974\ud0c4\uc758 \ub18d\ub3c4\ub294 \uc99d\uac00\uc2dc\ucf30\ub2e4. \uc774 \uc57d\uacfc CYP2C9 \uc5b5\uc81c\uc81c\uc758 \uc57d\ub825\ud559\uc801 \uc0c1\ud638\uc791\uc6a9\uc740 \uc5f0\uad6c\ub41c \ubc14 \uc5c6\ub2e4. \uc774 \uc57d\uc744 \ud65c\uc131 \ub300\uc0ac\uccb4\ub85c \ub300\uc0ac\ud558\uc9c0 \ubabb\ud558\ub294 \uc0ac\ub78c\uc740 CYP2C9\uc5d0 \ud76c\uadc0\ud558\uac8c \ud2b9\uc815 \uacb0\ud568\uc774 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4. \uc774 \uacb0\uacfc\ub85c \uc774 \uc57d\uc774 \ud65c\uc131\ub300\uc0ac\uccb4\ub85c \uc804\ud658\ub418\ub294\ub370 \uc788\uc5b4 \uc8fc\uc694\ud55c \uc5ed\ud560\uc744 \ud558\ub294 \ud6a8\uc18c\ub294 CYP3A4\uac00 \uc544\ub2cc CYP2C9\uc784\uc744 \uc54c \uc218 \uc788\ub2e4. \uc774 \uc57d\uacfc \uc544\uc138\ub178\ucfe0\ub9c8\ub864(acenocoumarol) \ubc0f \ud39c\ud504\ub85c\ucfe0\ubaac(phenprocoumon) \uc744 \ube44\ub86f\ud55c \uacbd\uad6c\uc6a9 \ud56d\uc751\uace0\uc81c\uc758 \uc7a0\uc7ac\uc801\uc778 \uc0c1\ud638\uc791\uc6a9\uc740 \uc5f0\uad6c\ub41c \ubc14 \uc5c6\ub2e4. 2) \uc548\uc9c0\uc624\ud150\uc2e0\u2161\ub97c \uc800\ud574\ud558\ub294 \ub2e4\ub978 \uc57d\ubb3c\uacfc \ub9c8\ucc2c\uac00\uc9c0\ub85c \uce7c\ub968\ubcf4\uc874\uc774\ub1e8\uc81c(\uc608, \uc2a4\ud53c\ub85c\ub178\ub77d\ud1a4, \ud2b8\ub9ac\uc554\ud14c\ub80c, \uc544\ubbf8\ub85c\ub9ac\ub4dc), \uce7c\ub968 \ubcf4\ucda9\uc81c, \uce7c\ub968\uc744 \ud568\uc720\ud55c \uc5fc\ubd84 \ub300\uc6a9\uc81c, \ub610\ub294 \ud608\uccad \uce7c\ub968 \ub18d\ub3c4\ub97c \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\ub294 \ub2e4\ub978 \uc57d\ubb3c(\uc608, \ud5e4\ud30c\ub9b0, \ud2b8\ub9ac\uba54\ud1a0\ud504\ub9bc \ud568\uc720\uc81c\uc81c)\uacfc\uc758 \ubcd1\uc6a9\uc740 \ud608\uccad \uce7c\ub968 \ub18d\ub3c4\ub97c \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\ub2e4. \ub530\ub77c\uc11c \uc774 \uc57d\uacfc\uc758 \ubcd1\uc6a9\uc774 \uad8c\uc7a5\ub418\uc9c0 \uc54a\ub294\ub2e4. 3) \ube44\uc2a4\ud14c\ub85c\uc774\ub4dc\uc18c\uc5fc\uc9c4\ud1b5\uc81c (NSAID) : \uc548\uc9c0\uc624\ud150\uc2e0\u2161\uc218\uc6a9\uccb4 \ucc28\ub2e8\uc81c\ub97c \ube44\uc2a4\ud14c\ub85c\uc774\ub4dc\uc18c\uc5fc\uc9c4\ud1b5\uc81c (\uc608, \uc120\ud0dd\uc801\uc778 COX-2 \uc5b5\uc81c\uc81c, \uc544\uc138\ud2f8\uc0b4\ub9ac\uc2e4\uc0b0 (&gt; 3 g\/day), \ube44\uc120\ud0dd\uc801 \ube44\uc2a4\ud14c\ub85c\uc774\ub4dc\uc18c\uc5fc\uc9c4\ud1b5\uc81c)\uc640 \ubcd1\uc6a9 \uc2dc \ud608\uc555 \uac15\ud558 \ud6a8\uacfc\uac00 \uac10\uc18c\ud560 \uc218 \uc788\ub2e4. ACE \uc5b5\uc81c\uc81c\uc640 \uac19\uc774, \uc548\uc9c0\uc624\ud150\uc2e0\u2161\uc218\uc6a9\uccb4 \ucc28\ub2e8\uc81c\uc640 \ube44\uc2a4\ud14c\ub85c\uc774\ub4dc\uc18c\uc5fc\uc9c4\ud1b5\uc81c\uc758 \ubcd1\uc6a9\uc740 \uc2e0\uae30\ub2a5\uc744 \uc545\ud654, \uae09\uc131 \uc2e0\ubd80\uc804\uc744 \uc720\ubc1c\uc2dc\ud0ac \uc218 \uc788\uace0, \ud608\uccad \uce7c\ub968\uc744 \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\ub2e4. \ubcd1\uc6a9 \uc2dc \uc8fc\uc758\ud574\uc57c \ud558\uba70, \ud2b9\ud788 \uace0\ub839\uc790 \ud639\uc740 \uc720\ud6a8\ud608\uc561\ub7c9 \uac10\uc18c\ud658\uc790 (\uc774\ub1e8\uc81c \uce58\ub8cc \uc911\uc778 \ud658\uc790\ub97c \ud3ec\ud568)\ub294 \uc8fc\uc758\ud55c\ub2e4. \ubcd1\uc6a9\uce58\ub8cc \uc2dc\uc791 \ud6c4\uc5d0 \ud658\uc790\uc5d0\uac8c \uc801\uc808\ud55c \uc218\ubd84\uc774 \uacf5\uae09\ub418\uc5b4\uc57c \ud558\uba70, \uc2e0\uae30\ub2a5\uc744 \uc8fc\uae30\uc801\uc73c\ub85c \ubaa8\ub2c8\ud130\ub9c1 \ud574\uc57c\ud55c\ub2e4. 4) \ub098\ud2b8\ub968 \ubc30\uc124\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \ub2e4\ub978 \uc57d\ubb3c\uacfc \ub9c8\ucc2c\uac00\uc9c0\ub85c, \uc774 \uc57d \ud22c\uc5ec \uc2dc \ub9ac\ud2ac\ubc30\uc124\uc774 \uac10\uc18c\ub418\uace0 \ub9ac\ud2ac \uc911\ub3c5\uc774 \ub098\ud0c0\ub0a0 \uc218 \uc788\ub2e4. \ub530\ub77c\uc11c \uc548\uc9c0\uc624\ud150\uc2e0\u2161\uc218\uc6a9\uccb4 \ucc28\ub2e8\uc81c\uc640 \ub9ac\ud2ac\uc744 \ubcd1\uc6a9 \uc2dc \ud608\uccad \ub0b4 \ub9ac\ud2ac \ub18d\ub3c4\ub97c \ubaa8\ub2c8\ud130\ub9c1\ud574\uc57c \ud55c\ub2e4. 5) \uc774 \uc57d\uacfc \ud608\uc555\uac15\ud558\ub97c \uc77c\uc73c\ud0ac \uc218 \uc788\ub294 \uc57d\ubb3c(\uc0bc\ud658\uacc4 \ud56d\uc6b0\uc6b8\uc81c, \ud56d\uc815\uc2e0\ubcd1\uc57d, \ubc14\ud074\ub85c\ud39c, \uc544\ubbf8\ud3ec\uc2a4\ud2f4)\uc744 \ubcd1\uc6a9\ud22c\uc5ec\ud558\ub294 \uacbd\uc6b0 \uc800\ud608\uc555\uc758 \uc704\ud5d8\uc774 \ucee4\uc9c8 \uc218 \uc788\ub2e4. 6) \uc548\uc9c0\uc624\ud150\uc2e0 \uc218\uc6a9\uccb4 \ucc28\ub2e8\uc81c(ARB), ACE \uc5b5\uc81c\uc81c \ub610\ub294 \uc54c\ub9ac\uc2a4\ud0a4\ub80c\uc758 \ubcd1\uc6a9\ud22c\uc5ec\uc5d0 \uc758\ud55c \ub808\ub2cc-\uc548\uc9c0\uc624\ud150\uc2e0-\uc54c\ub3c4\uc2a4\ud14c\ub860\uacc4 (RAAS)\uc758 \uc774\uc911\ucc28\ub2e8\uc740 \uc774\ub7ec\ud55c \uc57d\ubb3c\uc758 \ub2e8\ub3c5\uc694\ubc95\uacfc \ube44\uad50 \uc2dc \uc800\ud608\uc555, \uc2e4\uc2e0, \uace0\uce7c\ub968\ud608\uc99d \ubc0f \uc2e0\uae30\ub2a5\uc758 \ubcc0\ud654(\uae09\uc131 \uc2e0\ubd80\uc804 \ud3ec\ud568) \uc704\ud5d8\uc744 \uc99d\uac00\uc2dc\ud0a4\ub294 \uac83\uacfc \uad00\ub828\uc774 \uc788\ub2e4. \uc774 \uc57d\uacfc RAAS \uc5d0 \uc791\uc6a9\ud558\ub294 \ub2e4\ub978 \uc57d\ubb3c\uc744 \ubcd1\uc6a9\ud22c\uc5ec\ud558\ub294 \ud658\uc790\uc758 \uacbd\uc6b0, \ud608\uc555, \uc2e0\uae30\ub2a5 \ubc0f \uc804\ud574\uc9c8\uc744 \uba74\ubc00\ud788 \ubaa8\ub2c8\ud130\ub9c1\ud574\uc57c \ud55c\ub2e4. \ub2f9\ub1e8\ubcd1\uc774\ub098 \uc911\ub4f1\uc99d~\uc911\uc99d\uc758 \uc2e0\uc7a5\uc560 \ud658\uc790(\uc0ac\uad6c\uccb4 \uc5ec\uacfc\uc728 &lt;60 mL\/min\/1.73 m<sup>2<\/sup>)\uc5d0\uac8c \uc774 \uc57d\uacfc \uc54c\ub9ac\uc2a4\ud0a4\ub80c \ud568\uc720\uc81c\uc81c\ub97c \ubcd1\uc6a9\ud22c\uc5ec\ud558\uc9c0 \uc54a\ub294\ub2e4. 7) \uc790\ubabd\uc8fc\uc2a4\ub294 CYP450\uc744 \uc800\ud574\ud558\ub294 \uc131\ubd84\uc744 \ud568\uc720\ud558\uace0 \uc788\uc5b4 \uc774 \uc57d\uc758 \ud65c\uc131 \ub300\uc0ac\uc0b0\ubb3c \ub18d\ub3c4\ub97c \ub0ae\ucdb0 \uce58\ub8cc\ud6a8\uacfc\ub97c \uc800\ud558\uc2dc\ud0ac \uc218 \uc788\ub2e4. \ub530\ub77c\uc11c \uc774 \uc57d \ubcf5\uc6a9 \uc2dc \uc790\ubabd\uc8fc\uc2a4\ub97c \uc12d\ucde8\ud558\uc9c0 \uc54a\ub3c4\ub85d \ud55c\ub2e4. <strong>[<\/strong><strong>\uc784\ubd80<\/strong><strong> \ubc0f <\/strong><strong>\uc218\uc720\ubd80\uc5d0<\/strong><strong> <\/strong><strong>\ub300\ud55c<\/strong><strong> <\/strong><strong>\ud22c\uc5ec<\/strong><strong>] <\/strong>1) \uc784\ubd80. \ub808\ub2cc-\uc548\uc9c0\uc624\ud150\uc2e0-\uc54c\ub3c4\uc2a4\ud14c\ub860\uacc4\uc5d0 \uc9c1\uc811\uc801\uc73c\ub85c \uc791\uc6a9\ud558\ub294 \uc57d\ubb3c\uad70\uc740 \ubc1c\ub2ec \uc911\uc778 \ud0dc\uc544\uc758 \uc190\uc0c1 \ubc0f \uc0ac\ub9dd\uae4c\uc9c0\ub3c4 \ucd08\ub798\ud560 \uc218 \uc788\ub2e4. \ub85c\uc0ac\ub974\ud0c4\uc740 \uc784\uc2e0 \uc911\uc5d0 \uc0ac\uc6a9\ud574\uc11c\ub294 \uc548\ub418\uba70, \uc784\uc2e0\uc774 \ud655\uc778\ub418\uba74 \uac00\ub2a5\ud55c \ube68\ub9ac \ud22c\uc57d\uc744 \uc911\uc9c0\ud55c\ub2e4. \uc790\uad81 \ub0b4\uc5d0\uc11c \uc548\uc9c0\uc624\ud150\uc2e0 II \uc218\uc6a9\uccb4 \ucc28\ub2e8\uc81c\uc5d0 \ub178\ucd9c\ub41c \uc801\uc774 \uc788\ub294 \uc2e0\uc0dd\uc544, \uc601\u00b7\uc720\uc544\uc758 \uacbd\uc6b0\uc5d0\ub294 \uc800\ud608\uc555, \uc18c\ubcc0\uac10\uc18c\uc99d \ubc0f \uace0\uce7c\ub968\ud608\uc99d\uc774 \uc788\ub294\uc9c0 \uba74\ubc00\ud558\uac8c \uad00\ucc30\ud574\uc57c \ud55c\ub2e4. 2) \uc218\uc720\ubd80. \uc774 \uc57d\uc774 \ubaa8\uc720 \uc911\uc5d0 \ubd84\ube44\ub418\ub294 \uc9c0\uc758 \uc5ec\ubd80\ub294 \ubc1d\ud600\uc9c0\uc9c0 \uc54a\uc558\uc73c\ub098 \ub7ab\ud2b8\uc5d0 \ub300\ud55c \uc2e4\ud5d8\uc5d0\uc11c \uc720\uc999 \uc911\uc5d0 \uc774 \uc57d\uc758 \ubd84\ube44\uac00 \ud655\uc778\ub418\uc5c8\uc73c\ubbc0\ub85c \uc218\uc720\ubd80\uac00 \uc774 \uc57d\uc744 \uc0ac\uc6a9\ud558\ub294 \uac83\uc740 \ubc14\ub78c\uc9c1\ud558\uc9c0 \uc54a\ub2e4. \uc218\uc720 \uc911\uc778 \uc5ec\uc131\uc5d0\uac8c \uc774 \uc57d\uc758 \ud22c\uc5ec\ub97c \ud53c\ud558\uace0, \ubd80\ub4dd\uc774 \ud22c\uc5ec\ud558\ub294 \uacbd\uc6b0\uc5d0\ub294 \uc218\uc720\ub97c \uc911\ub2e8\ud574\uc57c \ud55c\ub2e4. <strong>[<\/strong><strong>\uc18c\uc544\uc5d0<\/strong><strong> <\/strong><strong>\ub300\ud55c<\/strong><strong> <\/strong><strong>\ud22c\uc5ec<\/strong><strong>]<\/strong> 6\uc138 \ubbf8\ub9cc\uc758 \uc18c\uc544\ud658\uc790, \uc0ac\uad6c\uccb4 \uc5ec\uacfc\uc728\uc774 30 mL\/min\/1.73 m<sup>2<\/sup> \ubbf8\ub9cc\uc778 \uc18c\uc544 \ubc0f \uccad\uc18c\ub144 \ud658\uc790\uc5d0\uc11c \uc774 \uc57d\uc758 \ud608\uc555\uac15\ud558\uc791\uc6a9\uc5d0 \ub300\ud55c \uc790\ub8cc\ub294 \uc5c6\uc73c\ubbc0\ub85c, \ud22c\uc5ec\ud558\uc9c0 \uc54a\ub294\ub2e4. <strong>[<\/strong><strong>\uace0\ub839\uc790\uc5d0<\/strong><strong> <\/strong><strong>\ub300\ud55c<\/strong><strong> <\/strong><strong>\ud22c\uc5ec<\/strong><strong>] <\/strong>\uace0\ud608\uc555\uc5d0 \ub300\ud55c \ub300\uc870 \uc784\uc0c1\uc2dc\ud5d8\uc5d0\uc11c \uc774 \uc57d\uc744 \ud22c\uc5ec \ubc1b\uc740 \ud658\uc790\ub4e4 \uc911\uc5d0\uc11c 391\uba85\uc758 \ud658\uc790 (19 %)\uac00 65 \uc138 \uc774\uc0c1\uc774\uc5c8\uc73c\uba70, \uadf8 \uc911 37\uba85(2 %)\uc740 75\uc138 \uc774\uc0c1\uc774\uc5c8\ub2e4. \ub2e8\ubc31\ub1e8\uac00 \uc788\ub294 \uc81c 2\ud615 \ub2f9\ub1e8\ubcd1 \ud658\uc790\uc758 \uc2e0\uc7a5 \ubcf4\ud638\uc5d0 \uad00\ud55c \ub300\uc870 \uc784\uc0c1\uc2dc\ud5d8\uc5d0\uc11c 248\uba85(33 %)\uc758 \ud658\uc790\uac00 65\uc138 \uc774\uc0c1\uc774\uc5c8\ub2e4. \uc88c\uc2ec\uc2e4 \ube44\ub300\uac00 \uc788\ub294 \uace0\ud608\uc555 \ud658\uc790\uc5d0 \ub300\ud574 \uc2ec\ud608\uad00 \uc0ac\ub9dd, \ub1cc\uc878\uc911, \uc2ec\uadfc\uacbd\uc0c9\uc758 \ubcf5\ud569 \uc704\ud5d8\ub3c4 \uac10\uc18c\ub97c \ud655\uc778\ud558\uae30 \uc704\ud55c \ub300\uc870 \uc784\uc0c1\uc2dc\ud5d8\uc5d0\uc11c 2,857\uba85(62 %)\uc758 \ud658\uc790\uac00 65\uc138 \uc774\uc0c1\uc774\uc5c8\uc73c\uba70 808\uba85(18 %)\uc758 \ud658\uc790\uac00 75\uc138 \uc774\uc0c1\uc774\uc5c8\ub2e4. \uc720\ud6a8\uc131 \ubc0f \uc548\uc804\uc131\uc5d0 \uc788\uc5b4\uc11c \uc774 \uace0\ub839\uc790\ub4e4\uacfc \uc80a\uc740 \ud658\uc790\ub4e4 \uc0ac\uc774\uc5d0 \uc804\ubc18\uc801\uc778 \ucc28\uc774\ub294 \uc5c6\uc5c8\uc73c\ub098, \uba87\uba87 \uace0\ub839\uc790\ub4e4\uc758 \uac10\uc218\uc131\uc758 \uc99d\uac00\ub97c \ubc30\uc81c\uc2dc\ud0ac \uc218\ub294 \uc5c6\ub2e4. \uac1c\uc815\ub144\uc6d4\uc77c : 2025\ub144 11\uc6d4 03\uc77c<strong>\u203b \ucc98\ubc29\ud558\uc2dc\uae30 \uc804\uc5d0 \uc81c\ud488\uc124\uba85\uc11c\ub97c \ucc38\uace0\ud558\uc2dc\uae30 \ubc14\ub78d\ub2c8\ub2e4<\/strong><\/p>\n\n\n\n<p><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\"><\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading has-text-color\" id=\"h-selective-safety-information-\ucf54\uc790-\ud50c\ub7ec\uc2a4\uc815-\ucf54\uc790-\ud50c\ub7ec\uc2a4\uc5d0\ud504\uc815-\ucf54\uc790-\ud50c\ub7ec\uc2a4\ud504\ub85c\uc815-\ub85c\uc0ac\ub974\ud0c4\uce7c\ub968-\ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc\" style=\"color:#0085cd\"><strong>Selective Safety Information \ucf54\uc790\u00ae\ud50c\ub7ec\uc2a4\uc815, \ucf54\uc790<strong>\u00ae<\/strong><\/strong>\ud50c\ub7ec\uc2a4\uc5d0\ud504\uc815, \ucf54\uc790<strong>\u00ae<\/strong>\ud50c\ub7ec\uc2a4\ud504\ub85c\uc815<strong> (\ub85c\uc0ac\ub974\ud0c4\uce7c\ub968-\ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc)<\/strong><\/h2>\n\n\n\n<p><strong>[<\/strong><strong>\ud6a8\ub2a5\u00b7\ud6a8\uacfc<\/strong><strong>]<\/strong> \ub2e8\uc77c\uc694\ubc95\uc73c\ub85c \ud608\uc555\uc774 \uc801\uc808\ud788 \uc870\uc808\ub418\uc9c0 \uc54a\ub294 \uace0\ud608\uc555<strong> [<\/strong><strong>\uc6a9\ubc95\u00b7\uc6a9\ub7c9<\/strong><strong>]<\/strong> 1) \uc131\uc778 : \uc774 \uc57d\uc758 \uc0c1\uc6a9\ub7c9\uc740 \ub85c\uc0ac\ub974\ud0c4\uce7c\ub968 50 mg\/\ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc 12.5 mg 1\uc77c 1\ud68c 1\uc815\uc774\ub2e4. 1\uc77c \ub85c\uc0ac\ub974\ud0c4\uce7c\ub968 100 mg\/\ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc 25 mg\uc744 \ucd08\uacfc\ud558\ub294 \uc6a9\ub7c9\uc740 \ubc14\ub78c\uc9c1\ud558\uc9c0 \uc54a\ub2e4. \uc77c\ubc18\uc801\uc73c\ub85c \ucd5c\ub300 \ud608\uc555\uac15\ud558 \ud6a8\uacfc\ub294 \uce58\ub8cc\uc2dc\uc791 \ud6c4 3\uc8fc\uacbd\uc5d0 \ub098\ud0c0\ub09c\ub2e4. \uc774 \uc57d\uc740 \ub2e4\ub978 \ud56d\uace0\ud608\uc555 \uc81c\uc81c\uc640 \ud568\uaed8 \ud22c\uc5ec\ud560 \uc218 \uc788\uc73c\uba70, \uc2dd\uc0ac\uc640 \uad00\uacc4\uc5c6\uc774 \ud22c\uc5ec\ud560 \uc218 \uc788\ub2e4. \uc774\uc0c1\ubc18\uc751\uc744 \ucd5c\uc18c\ud654\ud558\uae30 \uc704\ud574\uc11c, \ub2e8\uc77c\uc694\ubc95\uc73c\ub85c\ub294 \uae30\ub300\ud55c \ud6a8\uacfc\uac00 \ub098\ud0c0\ub098\uc9c0 \uc54a\uc744 \ub54c \uc774 \uc57d\uc758 \ud22c\uc5ec\ub97c \uc2dc\uc791\ud55c\ub2e4. 1. \ub300\uccb4\uc694\ubc95 : \uc6a9\ub7c9 \uc870\uc808\ub41c \uac01\uac01\uc758 \ub85c\uc0ac\ub974\ud0c4\uce7c\ub968\uacfc \ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc \ubcd1\uc6a9\uc694\ubc95\uc744 \uc774 \uc57d\uc73c\ub85c \uce58\ud658\ud560 \uc218 \uc788\ub2e4. 2. \ub85c\uc0ac\ub974\ud0c4 \ub610\ub294 \ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc \ub2e8\uc77c\uc694\ubc95\uc73c\ub85c\ub294 \ud608\uc555\uc774 \uc870\uc808\ub418\uc9c0 \uc54a\ub294 \ud658\uc790 : \ub85c\uc0ac\ub974\ud0c4\uce7c\ub968 50 mg\/\ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc 12.5 mg 1\uc77c 1\ud68c 1\uc815 \uc694\ubc95\uc73c\ub85c \uc2dc\uc791\ud558\uba70, \ubcf5\uc6a9 3\uc8fc \ud6c4\uc5d0\ub3c4 \ud608\uc555\uc774 \uc870\uc808\ub418\uc9c0 \uc54a\ub294 \uacbd\uc6b0\uc5d0\ub294 \ucd5c\ub300 \ub85c\uc0ac\ub974\ud0c4\uce7c\ub968 100 mg\/\ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc 25 mg 1\uc77c 1\ud68c 1\uc815\uc73c\ub85c \uc99d\ub7c9\ud560 \uc218 \uc788\ub2e4. 3. \ub85c\uc0ac\ub974\ud0c4\uce7c\ub968 100 mg \ub2e8\uc77c\uc694\ubc95\uc73c\ub85c\ub294 \ud608\uc555\uc774 \uc870\uc808\ub418\uc9c0 \uc54a\ub294 \ud658\uc790 : \ub85c\uc0ac\ub974\ud0c4\uce7c\ub968 100 mg\/\ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc 12.5 mg 1\uc77c 1\ud68c \uc694\ubc95\uc73c\ub85c \uc2dc\uc791\ud558\uba70, \ubcf5\uc6a9 3\uc8fc \ud6c4\uc5d0\ub3c4 \ud608\uc555\uc774 \uc870\uc808\ub418\uc9c0 \uc54a\ub294 \uacbd\uc6b0\uc5d0\ub294 \ucd5c\ub300 \ub85c\uc0ac\ub974\ud0c4\uce7c\ub968 100 mg\/\ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc 25 mg 1\uc77c 1\ud68c 1\uc815\uae4c\uc9c0 \uc99d\ub7c9\ud560 \uc218 \uc788\ub2e4. 4. 1\uc77c 1\ud68c 25 mg\uc758 \ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc\ub85c \ud608\uc555\uc774 \uc870\uc808\ub418\uc9c0 \uc54a\uac70\ub098, \uc774 \uc6a9\ub7c9\uc73c\ub85c \ud608\uc555\uc774 \uc870\uc808\ub418\ub354\ub77c\ub3c4 \uc800\uce7c\ub968\ud608\uc99d\uc744 \ubcf4\uc774\ub294 \ud658\uc790 : \uc804\uccb4\uc801\uc778 \ud608\uc555\uac15\ud558 \uc791\uc6a9\uc740 \uac10\uc18c\uc2dc\ud0a4\uc9c0 \uc54a\uc73c\uba74\uc11c\ub3c4 \ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc\uc758 \uc6a9\ub7c9\uc744 \uac10\uc18c\uc2dc\ud0ac \uc218 \uc788\ub294 \ub85c\uc0ac\ub974\ud0c4\uce7c\ub968 50 mg\/\ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc 12.5 mg 1\uc77c 1\ud68c 1\uc815 \uc694\ubc95\uc73c\ub85c \uc2dc\uc791\ud560 \uc218 \uc788\ub2e4. \uc774\ud6c4 \ub85c\uc0ac\ub974\ud0c4\uce7c\ub968 50 mg\/\ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc 12.5 mg\uc5d0 \ub300\ud55c \uc784\uc0c1\ubc18\uc751\uc744 \uc9c0\uc18d\uc801\uc73c\ub85c \uce21\uc815\ud558\uc5ec \ubcf5\uc6a9 3\uc8fc \ud6c4\uc5d0\ub3c4 \ud608\uc555\uc774 \uc870\uc808\ub418\uc9c0 \uc54a\ub294 \uacbd\uc6b0\uc5d0\ub294 \ub85c\uc0ac\ub974\ud0c4\uce7c\ub968 100 mg\/\ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc 25 mg 1\uc77c 1\ud68c 1\uc815\uae4c\uc9c0 \uc99d\ub7c9\ud560 \uc218 \uc788\ub2e4. 2) \uc2e0\uc7a5\uc560 \ud658\uc790 : \ud06c\ub808\uc544\ud2f0\ub2cc\uccad\uc18c\uc728\uc774 30 mL\/min \uc774\uc0c1\uc778 \uacbd\uc6b0\uc5d0\ub294 \uc0c1\uc6a9\ub7c9\uc744 \ud22c\uc5ec\ud55c\ub2e4. \ubcf4\ub2e4 \uc2ec\uac01\ud55c \uc2e0\uc7a5\uc560\ub97c \uac00\uc9c4 \ud658\uc790\uc5d0\uac8c\ub294 \ud2f0\uc544\uc9c0\ub4dc\uacc4\uc758 \uc57d\ubb3c\ubcf4\ub2e4\ub294 \ub8e8\ud504\uacc4 \uc774\ub1e8\uc81c\ub97c \uc0ac\uc6a9\ud558\ub294 \uac83\uc774 \ubc14\ub78c\uc9c1\ud558\ubbc0\ub85c \uc774\ub7ec\ud55c \ud658\uc790\uc5d0 \ub300\ud55c \ud22c\uc5ec\ub294 \uad8c\uc7a5\ub418\uc9c0 \uc54a\ub294\ub2e4. 3) \uac04\uc7a5\uc560 \ud658\uc790 : \uc6a9\ub7c9 \uc870\uc808\uc774 \ud544\uc694\ud55c \uac04\uc7a5\uc560 \ud658\uc790\uc5d0 \ub300\ud55c \ub85c\uc0ac\ub974\ud0c4\uce7c\ub968\uc758 \ucd08\ud68c\ud22c\uc5ec\ub7c9\uc778 25 mg\uc744 \uc774 \uc57d\uc73c\ub85c\ub294 \ud22c\uc5ec\ud560 \uc218 \uc5c6\uc73c\ubbc0\ub85c, \uc774\ub7ec\ud55c \ud658\uc790\uc5d0 \ub300\ud55c \ud22c\uc5ec\ub294 \uad8c\uc7a5\ub418\uc9c0 \uc54a\ub294\ub2e4.4) \uc18c\uc544(18\uc138 \ubbf8\ub9cc). \uc18c\uc544 \ubc0f \uccad\uc18c\ub144\uc5d0 \ub300\ud55c \uc0ac\uc6a9\uacbd\ud5d8\uc774 \uc5c6\uc73c\ubbc0\ub85c \ub85c\uc0ac\ub974\ud0c4-\ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc \ubcf5\ud569\uc81c\ub294 \uc18c\uc544 \ubc0f \uccad\uc18c\ub144\uc5d0\uac8c \ud22c\uc5ec\ud558\uc9c0 \uc54a\ub294\ub2e4. <strong>[<\/strong><strong>\uacbd\uace0<\/strong><strong>] <\/strong>\uc784\ubd80\uc5d0\uac8c \ub808\ub2cc-\uc548\uc9c0\uc624\ud150\uc2e0-\uc54c\ub3c4\uc2a4\ud14c\ub860\uacc4(RAAS)\uc5d0 \uc9c1\uc811 \uc791\uc6a9\ud558\ub294 \uc57d\ubb3c\ub4e4\uc758 \ud22c\uc5ec \uc2dc, \ud0dc\uc544 \ubc0f \uc2e0\uc0dd\uc544\uc5d0\uac8c \uc190\uc0c1 \ubc0f \uc0ac\ub9dd\uae4c\uc9c0\ub3c4 \uc77c\uc5b4\ub0a0 \uc218 \uc788\ub2e4. \uc591\uc218\uacfc\uc18c\uc99d\uc758 \ubc1c\uc0dd\uc740 \ud0dc\uc544\uc758 \ud3d0 \ud615\uc131 \uc800\ud558\uc99d \ubc0f \uace8\uaca9 \uae30\ud615\uacfc \uad00\ub828\uc774 \uc788\uc744 \uc218 \uc788\ub2e4. \uc2e0\uc0dd\uc544\uc5d0\uac8c \ub098\ud0c0\ub0a0 \uac00\ub2a5\uc131\uc774 \uc788\ub294 \ubd80\uc791\uc6a9\uc740 \ub450\uac1c\uace8 \ud615\uc131 \uc800\ud558\uc99d, \ubb34\ub1e8\uc99d, \uc800\ud608\uc555, \uc2e0\ubd80\uc804\uacfc \uc0ac\ub9dd \ub4f1\uc744 \ud3ec\ud568\ud55c\ub2e4. \uc784\uc2e0\uc774 \ud655\uc778\ub418\uba74 \uac00\ub2a5\ud55c \ube68\ub9ac \uc774 \uc57d\uc744 \uc911\ub2e8\ud574\uc57c \ud55c\ub2e4. <strong>[<\/strong><strong>\uae08\uae30<\/strong><strong>]<\/strong> 1) \uc774 \uc57d \ub610\ub294 \uc774 \uc57d\uc758 \uad6c\uc131\uc131\ubd84\uc5d0 \uacfc\ubbfc\ubc18\uc751 \ud658\uc790 2) \ubb34\ub1e8\uc99d\uc774 \uc788\uac70\ub098 \uc124\ud3f0\uc544\ubbf8\ub4dc\uacc4 \uc57d\ubb3c\uc5d0 \uacfc\ubbfc\ubc18\uc751 \ub610\ub294 \uadf8 \ubcd1\ub825\uc758 \ud658\uc790 3) \uce58\ub8cc\ubd88\uc751\uc131 \uc800\uce7c\ub968\ud608\uc99d, \uace0\uce7c\uc298\ud608\uc99d, \uc800\ub098\ud2b8\ub968\ud608\uc99d \ub610\ub294 \uccb4\uc561 \uc911 \ub098\ud2b8\ub968\u00b7\uce7c\ub968\uc774 \uba85\ubc31\ud788 \uac10\uc18c\ub41c \ud658\uc790 4) \uc911\uc99d \uac04\uc7a5\uc560 \ud658\uc790, \ub2f4\uc999\uc815\uccb4 \ubc0f \ub2f4\ub3c4\ud3d0\uc1c4\uc7a5\uc560 \ud658\uc790 5) \uc99d\uc0c1\uc774 \uc788\ub294 \uace0\uc694\uc0b0\ud608\uc99d\/\ud1b5\ud48d \ud658\uc790 6) \uc784\ubd80 \ub610\ub294 \uc784\uc2e0\ud558\uace0 \uc788\uc744 \uac00\ub2a5\uc131\uc774 \uc788\ub294 \uc5ec\uc131 7) \uc911\uc99d \uc2e0\uc7a5\uc560 \ud658\uc790 (\uc608, \ud06c\ub808\uc544\ud2f0\ub2cc\uccad\uc18c\uc728 30 mL\/min \ubbf8\ub9cc) \ub610\ub294 \uae09\uc131\uc2e0\ubd80\uc804 \ud658\uc790 8) \ud22c\uc11d\uc911\uc778 \ud658\uc790 9) \uc774 \uc57d\uc740 \uc720\ub2f9\uc744 \ud568\uc720\ud558\uace0 \uc788\uc73c\ubbc0\ub85c, \uac08\ub77d\ud1a0\uc624\uc2a4 \ubd88\ub0b4\uc131(galactose intolerance), Lapp \uc720\ub2f9\ubd84\ud574\ud6a8\uc18c \uacb0\ud54d\uc99d(Lapp lactase deficiency) \ub610\ub294 \ud3ec\ub3c4\ub2f9-\uac08\ub77d\ud1a0\uc624\uc2a4 \ud761\uc218\uc7a5\uc560(glucose-galactose malabsorption) \ub4f1\uc758 \uc720\uc804\uc801\uc778 \ubb38\uc81c\uac00 \uc788\ub294 \ud658\uc790\uc5d0\uac8c\ub294 \ud22c\uc5ec\ud558\uba74 \uc548 \ub41c\ub2e4. 10) \ub2f9\ub1e8\ubcd1\uc774\ub098 \uc911\ub4f1\ub3c4~\uc911\uc99d\uc758 \uc2e0\uc7a5\uc560 \ud658\uc790 (\uc0ac\uad6c\uccb4\uc5ec\uacfc\uc728 &lt;60 mL\/min\/1.73 m<sup>2<\/sup>)\uc5d0\uc11c \uc54c\ub9ac\uc2a4\ud0a4\ub80c \ud568\uc720\uc81c\uc81c\uc640\uc758 \ubcd1\uc6a9 <strong>[<\/strong><strong>\uc2e0\uc911\ud22c\uc5ec<\/strong><strong>]<\/strong> 1) \uc800\ud608\uc555-\ud608\uad00\ub0b4 \uc720\ud6a8 \ud608\uc561\ub7c9 \uac10\uc18c \ud658\uc790 2) \uc2e0\uc7a5\uc560 \ud658\uc790, \ud3b8\uce21\uc131 \ud639\uc740 \uc591\uce21\uc131 \uc2e0\ub3d9\ub9e5 \ud611\ucc29\uc99d\uc774 \uc788\ub294 \ud658\uc790 3) \uac04\uc7a5\uc560 \ud658\uc790 \ub610\ub294 \uac04\uc7a5\uc560 \ubcd1\ub825 \ud658\uc790 4) \uc804\uc2e0\uc131 \ud64d\ubc18\uc131 \ub8e8\ud478\uc2a4 \ud658\uc790 5) \ud608\uccad \uce7c\ub968\uce58 \uc774\uc0c1 \ud658\uc790 6) \ub1cc\ud608\uad00\uc7a5\uc560 \ud658\uc790 7) \uac10\uc5fc\uc694\ubc95 \uc911\uc778 \ud658\uc790 8) \uc911\uc99d \uad00\uacbd\ud654\uc99d \ub610\ub294 \ub1cc\ub3d9\ub9e5\uacbd\ud654\uc99d \ud658\uc790 9) \ubcf8\uc778\uc5d0 \ub2f9\ub1e8\ubcd1 \ub610\ub294 \ubd80\ubaa8, \ud615\uc81c\uc5d0 \ud1b5\ud48d, \ub2f9\ub1e8\ubcd1 \ub610\ub294 \uace0\uc694\uc0b0\ud608\uc99d\uc774 \uc788\ub294 \ud658\uc790 10) \uc124\uc0ac, \uad6c\ud1a0 \ud658\uc790 11) \uace0\uce7c\uc298\ud608\uc99d, \ubd80\uac11\uc0c1\uc0d8\uae30\ub2a5\ud56d\uc9c4\uc99d \ud658\uc790 12) \ub514\uae30\ud0c8\ub9ac\uc2a4, \ubd80\uc2e0\ud53c\uc9c8\ud638\ub974\ubaac\uc81c \ub610\ub294 ACTH\ub97c \ud22c\uc5ec \uc911\uc778 \ud658\uc790 13) \uad50\uac10\uc2e0\uacbd\uc808\uc81c \ud6c4 \ud658\uc790 14) \uace0\ub839\uc790 15) \ub808\ub2cc-\uc548\uc9c0\uc624\ud150\uc2e0-\uc54c\ub3c4\uc2a4\ud14c\ub860\uacc4(RAAS)\uc758 \uc774\uc911\ucc28\ub2e8 16) \ube44\ud751\uc0c9\uc885 \ud53c\ubd80\uc554 (NMSC). \ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc \ub178\ucd9c \ub204\uc801\uc6a9\ub7c9 \uc99d\uac00\uc5d0 \ub530\ub978 \ube44\ud751\uc0c9\uc885 \ud53c\ubd80\uc554(\uae30\uc800\uc138\ud3ec\uc554, \ud3b8\ud3c9\uc138\ud3ec\uc554)\uc758 \uc99d\uac00 \uc704\ud5d8\uc774 \ub374\ub9c8\ud06c \uad6d\ub9bd \uc554 \ub808\uc9c0\uc2a4\ud2b8\ub9ac\uc5d0 \uadfc\uac70\ud55c \ub450 \uac74\uc758 \uc5ed\ud559\uc5f0\uad6c\uc5d0\uc11c \ubcf4\uace0\ub418\uc5c8\ub2e4. \ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc\uc758 \uad11\uacfc\ubbfc \uc791\uc6a9\uc740 \ube44\ud751\uc0c9\uc885 \ud53c\ubd80\uc554 \uae30\uc804\uc73c\ub85c \uc791\uc6a9\ud560 \uc218 \uc788\ub2e4. \ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc\ub97c \ubcf5\uc6a9\ud558\ub294 \ud658\uc790\uc5d0\uac8c\ub294 \ube44\ud751\uc0c9\uc885 \ud53c\ubd80\uc554 \uc704\ud5d8\uc5d0 \ub300\ud55c \uc815\ubcf4\ub97c \uc81c\uacf5\ud574\uc57c \ud558\uace0, \uc815\uae30\uc801\uc73c\ub85c \ud53c\ubd80\uc758 \uc0c8\ub85c\uc6b4 \ubcd1\ubcc0 \ubc1c\uc0dd \uc5ec\ubd80\ub97c \ud655\uc778\ud558\uace0 \uc758\uc2ec\uc2a4\ub7ec\uc6b4 \ud53c\ubd80 \ubcd1\ubcc0\uc774 \ubc1c\uacac\ub420 \uacbd\uc6b0 \ubcf4\uace0\ud558\ub3c4\ub85d \uad8c\uace0\ud574\uc57c \ud55c\ub2e4. \ub610\ud55c \ud658\uc790\uc5d0\uac8c \ud53c\ubd80\uc554 \uc704\ud5d8\uc744 \ucd5c\uc18c\ud654\ud558\uae30 \uc704\ud574 \ud587\ube5b\uc774\ub098 UV(\uc790\uc678\uc120) \ub178\ucd9c \uc81c\ud55c \ubc0f \ub178\ucd9c\ub418\ub294 \uacbd\uc6b0 \uc801\uc808\ud55c \ubcf4\ud638\uc640 \uac19\uc740 \uac00\ub2a5\ud55c \uc608\ubc29 \uc870\uce58\ub97c \uad8c\uace0\ud574\uc57c \ud55c\ub2e4. \uc758\uc2ec\ub418\ub294 \ud53c\ubd80 \ubcd1\ubcc0\uc740 \uc870\uc9c1 \uc0dd\uac80\uc744 \ud3ec\ud568\ud55c \uac80\uc0ac\ub97c \uc989\uc2dc \uc2e4\uc2dc\ud55c\ub2e4. \uc774\uc804\uc5d0 \ube44\ud751\uc0c9\uc885 \ud53c\ubd80\uc554 \ubcd1\ub825\uc774 \uc788\ub294 \ud658\uc790\uc5d0\uac8c\ub294 \ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc\uc758 \uc0ac\uc6a9\uc744 \uc7ac\uace0\ud560 \ud544\uc694\uac00 \uc788\ub2e4.<strong> [<\/strong><strong>\uc774\uc0c1\ubc18\uc751<\/strong><strong>]<\/strong> 1) \ub85c\uc0ac\ub974\ud0c4\uce7c\ub968-\ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc \ubcf5\ud569\uc81c\uc778 \uc774 \uc57d\uc758 \uc548\uc804\uc131\uc740 858\uba85\uc758 \ubcf8\ud0dc\uace0\ud608\uc555 \ud658\uc790\uc640 \uc88c\uc2ec\uc2e4 \ube44\ub300\uac00 \uc788\ub294 \uace0\ud608\uc555 \ud658\uc790 3,889\uba85\uc5d0\uc11c \ud3c9\uac00\ub418\uc5c8\ub2e4. \uc774 \uc784\uc0c1 \uc2dc\ud5d8\uc5d0\uc11c \uc774 \uc57d\uc5d0 \ud2b9\uc774\uc801\uc778 \uc774\uc0c1\ubc18\uc751\uc740 \uad00\ucc30\ub418\uc9c0 \uc54a\uc558\uc73c\uba70, \uad00\ucc30\ub41c \uc774\uc0c1\ubc18\uc751\uc740 \ub85c\uc0ac\ub974\ud0c4\uc774\ub098 \ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc \ub2e8\uc77c\uc81c\uc81c\uc5d0\uc11c \ubcf4\uace0\ub418\uc5c8\ub358 \uac83\uc5d0 \uad6d\ud55c\ub418\uc5c8\ub2e4. \uc774 \uc57d\uc740 \ub0b4\uc57d\uc131\uc774 \uc6b0\uc218\ud558\uc5ec \uc774 \uc57d \ud22c\uc5ec\ub85c \uc778\ud55c \uc804\uccb4\uc801\uc778 \uc774\uc0c1\ubc18\uc751 \ubc1c\ud604\uc728\uc740 \uc704\uc57d\ub300\uc870\uad70\uacfc \uc720\uc0ac\ud558\uc600\ub2e4. \ub300\ubd80\ubd84\uc758 \uc774\uc0c1\ubc18\uc751\uc740 \uacbd\ubbf8\ud558\uace0 \uc77c\uc2dc\uc801\uc774\uc5c8\uc73c\uba70 \ud22c\uc57d\uc744 \uc911\ub2e8\ud560 \uc815\ub3c4\ub294 \uc544\ub2c8\uc5c8\ub2e4. \uc704\uc57d\ub300\uc870\uc2dc\ud5d8\uc5d0\uc11c \uc774\uc0c1\ubc18\uc751\uc73c\ub85c \uc778\ud55c \ud22c\uc57d\uc911\ub2e8\uc740 \ud22c\uc57d\uad70\uacfc \uc704\uc57d\ub300\uc870\uad70\uc758 \uac01\uac01 2.8%\uc640 2.3%\uc5d0\uc11c \ub098\ud0c0\ub0ac\ub2e4. 2) \uc2dc\ud310 \ud6c4 \ucd94\uac00 \ubcf4\uace0 (1) \uacfc\ubbfc\ubc18\uc751 : \ud608\uad00\ubd80\uc885(\uae30\ub3c4 \ud3d0\uc1c4\ub97c \uc57c\uae30\ud560 \uc218 \uc788\ub294 \ud6c4\ub450\/\uc131\ubb38\uc758 \ud33d\uc724, \uc5bc\uad74\/\uc785\uc220\/\uc778\ub450\/\ud600\uc758 \ud33d\uc724)\uc774 \ub85c\uc0ac\ub974\ud0c4\uc744 \ud22c\uc5ec\ubc1b\uc740 \ud658\uc790\uc5d0\uc11c \ub4dc\ubb3c\uac8c \ubcf4\uace0\ub418\uc5c8\uc73c\uba70, \uc774\ub4e4 \uc774\uc0c1\ubc18\uc751\uc744 \ubcf4\uc778 \ud658\uc790 \uc911 \uc77c\ubd80\ub294 \uc774\uc804\uc5d0 ACE \uc5b5\uc81c\uc81c \ub4f1\uc758 \ub2e4\ub978 \uc57d\uc81c\uc5d0 \ub300\ud574\uc11c\ub3c4 \ud608\uad00\ubd80\uc885\uc744 \uacbd\ud5d8\ud55c \uc801\uc774 \uc788\uc5c8\ub2e4. \uc7a5 \ud608\uad00 \ubd80\uc885\uc740 \ub85c\uc0ac\ub974\ud0c4\uc744 \ube44\ub86f\ud55c \uc548\uc9c0\uc624\ud150\uc2e0 II \uc218\uc6a9\uccb4 \ucc28\ub2e8\uc81c\ub85c \uce58\ub8cc\ubc1b\uc740 \ud658\uc790\uc5d0\uc11c \ubcf4\uace0\ub41c \ubc14 \uc788\ub2e4. \ub85c\uc0ac\ub974\ud0c4\uc744 \ud22c\uc5ec\ud55c \ud658\uc790\uc5d0\uac8c\uc11c \ud608\uad00\uc5fc(Henoch\u2010Sch\u00f6nlein purpura \uc790\ubc18\uc99d \ud3ec\ud568)\uc774 \ubcf4\uace0\ub418\uc5c8\ub2e4. \uc544\ub098\ud544\ub77d\uc2dc\uc2a4 \ubc18\uc751\ub3c4 \ubcf4\uace0\ub418\uc5c8\ub2e4.&nbsp;<strong>[<\/strong><strong>\uc77c\ubc18\uc801<\/strong><strong> <\/strong><strong>\uc8fc\uc758<\/strong><strong>]<\/strong> 1) \uacfc\ubbfc\ubc18\uc751 : \ud608\uad00\ubd80\uc885 2) \uc7a5 \ud608\uad00 \ubd80\uc885\uc774 \uc548\uc9c0\uc624\ud150\uc2e0 \u2161 \uc218\uc6a9\uccb4 \ucc28\ub2e8\uc81c\ub97c \ud22c\uc5ec\ubc1b\uc740 \ud658\uc790\uc5d0\uc11c \ubcf4\uace0\ub418\uc5c8\ub2e4. \ubcf5\ud1b5, \uba54\uc2a4\uaebc\uc6c0, \uad6c\ud1a0 \ubc0f \uc124\uc0ac\uac00 \ubcf4\uace0\ub418\uc5c8\uace0, \ud22c\uc5ec \uc911\ub2e8 \ud6c4 \uc99d\uc0c1\uc774 \uc644\ud654\ub418\uc5c8\ub2e4. \uc7a5 \ud608\uad00 \ubd80\uc885\uc774 \ud655\uc778\ub418\uba74 \ud22c\uc5ec\ub97c \uc911\ub2e8\ud558\uace0 \uc99d\uc0c1\uc774 \uc644\ud654\ub420 \ub54c\uae4c\uc9c0 \uc801\uc808\ud788 \ubaa8\ub2c8\ud130\ub9c1 \ud574\uc57c \ud55c\ub2e4. 3) \ub85c\uc0ac\ub974\ud0c4\/\ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc. \ud608\uad00\ub0b4 \uc720\ud6a8 \ud608\uc561\ub7c9\uc774 \uac10\uc18c\ud55c \ud658\uc790(\uc608, \uc774\ub1e8\uc81c\ub97c \ubcf5\uc6a9\uc911\uc778 \ud658\uc790)\uc5d0\uc11c\ub294 \uc774 \uc57d \ud22c\uc5ec \uc2dc\uc5d0 \uc800\ud608\uc555 \uc99d\uc0c1\uc774 \ub098\ud0c0\ub0a0 \uc218 \uc788\uc73c\ubbc0\ub85c \uc774 \uc57d\uc744 \ud22c\uc5ec\ud558\uae30 \uc804\uc5d0 \uc801\uc808\ud55c \uc870\uce58\ub97c \ucde8\ud558\uc5ec\uc57c \ud55c\ub2e4. 4) \ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc(1) \uc804\ud574\uc9c8 \ubd88\uade0\ud615 \uc5ec\ubd80\ub97c \ud30c\uc545\ud558\uae30 \uc704\ud574\uc11c \uc815\uae30\uc801\uc73c\ub85c \ud608\uccad \uc804\ud574\uc9c8 \uac80\uc0ac\ub97c \uc2e4\uc2dc\ud574\uc57c \ud55c\ub2e4. \uccb4\uc561\uc774\ub098 \uc804\ud574\uc9c8 \ubd88\uade0\ud615\uc73c\ub85c \uc778\ud55c \uc784\uc0c1 \uc9d5\ud6c4\uac00 \ub098\ud0c0\ub098\ub294\uc9c0 \uad00\ucc30\ud574\uc57c \ud558\uba70, \ud658\uc790\uac00 \uc2ec\ud55c \uad6c\ud1a0\ub97c \ud55c\ub2e4\uac70\ub098 \ube44\uacbd\uad6c\uc801\uc73c\ub85c \uc561\uccb4\ub97c \ud22c\uc5ec\ubc1b\uace0 \uc788\uc744 \ub54c\uc5d0\ub294 \ud608\uccad \ubc0f \uc694\uc911\uc758 \uc804\ud574\uc9c8\uc744 \uce21\uc815\ud574\uc57c \ud55c\ub2e4. (2) \uc911\uc99d\uc758 \uac04\uacbd\ubcc0\uc774 \uc788\uac70\ub098, \uce58\ub8cc\uac00 \uc7a5\uae30\uac04 \uc9c0\uc18d\ub418\uba74 \uac70\ud488 \uc11e\uc778 \uc694\uc758 \uc99d\uac00\uc640 \ud568\uaed8 \uc800\uce7c\ub968\ud608\uc99d\uc774 \ubc1c\uc0dd\ud560 \uc218 \uc788\ub2e4. (3) \uc800\uc5fc\uc18c\ud608\uc99d\uc740 \uadf8 \uc99d\uc0c1\uc774 \uc77c\ubc18\uc801\uc73c\ub85c \uacbd\ubbf8\ud558\uc5ec \ud2b9\ubcc4\ud55c \uacbd\uc6b0\ub97c \uc81c\uc678\ud558\uace0\ub294 \uce58\ub8cc\ub97c \ud544\uc694\ub85c \ud558\uc9c0 \uc54a\uc9c0\ub9cc, \ub300\uc0ac\uc131 \uc54c\uce7c\ub9ac\ud608\uc99d \uc2dc\uc5d0\ub294 \uc5fc\uc18c\ub97c \ubcf4\ucda9\ud574 \uc8fc\uc5b4\uc57c \ud55c\ub2e4. (4) \ub354\uc6b4 \ub0a0\uc528\uc5d0\ub294 \uc218\uc885 \ud658\uc790\uc5d0\uc11c \ud76c\uc11d\uc131 \uc800\ub098\ud2b8\ub968\ud608\uc99d\uc774 \uc77c\uc5b4\ub0a0 \uc218 \uc788\ub2e4. (5) \ud2f0\uc544\uc9c0\ub4dc\uacc4 \uc57d\ubb3c\uc744 \ud22c\uc5ec\ubc1b\ub294 \uc77c\ubd80 \ud658\uc790\uc5d0\uc11c \uace0\uc694\uc0b0\ud608\uc99d\uc774\ub098 \ud1b5\ud48d\uc774 \ubc1c\uc0dd\ud560 \uc218 \uc788\ub2e4. (6) \ud2f0\uc544\uc9c0\ub4dc\uacc4 \uc57d\ubb3c\uc758 \ud22c\uc5ec\ub85c \uace0\ud608\ub2f9\uc774 \uc77c\uc5b4\ub0a0 \uc218\ub3c4 \uc788\ub2e4. \ub530\ub77c\uc11c \ub2f9\ub1e8 \ud658\uc790\uc5d0\uac8c \ud22c\uc5ec\uc2dc\uc5d0\ub294 \uc778\uc290\ub9b0\uc774\ub098 \ud608\ub2f9\uac15\ud558\uc81c\uc758 \uc6a9\ub7c9\uc870\uc808\uc774 \ud544\uc694\ud560 \uc218 \uc788\ub2e4. \ub610\ud55c \ud2f0\uc544\uc9c0\ub4dc\uacc4 \uc57d\ubb3c\uc744 \ud22c\uc5ec\ubc1b\ub294 \ub3d9\uc548 \uc7a0\uc7ac\uc131 \ub2f9\ub1e8\uac00 \ud604\uc131\ud654 \ub420 \uc218\ub3c4 \uc788\ub2e4. (7) \ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc\uc758 \ud608\uc555 \uac15\ud558 \uc791\uc6a9\uc740 \uad50\uac10\uc2e0\uacbd\uc744 \uc808\uc81c\ud55c \ud658\uc790\uc5d0\uac8c\uc11c\ub294 \uc99d\uac15\ub420 \uc218 \uc788\ub2e4. (8) \uc9c4\ud589\uc131 \uc2e0\uc7a5\uc560 \ud658\uc790\uc5d0 \ub300\ud574\uc11c\ub294 \uc774\ub1e8\uc81c \ud22c\uc5ec\uc758 \ubcf4\ub958\ub098, \uc911\ub2e8\uc744 \uace0\ub824\ud558\uc5ec\uc57c \ud55c\ub2e4. (9) \ud608\uc911 \ucf5c\ub808\uc2a4\ud14c\ub864\uce58\uc640 \ud2b8\ub9ac\uae00\ub9ac\uc138\ub77c\uc774\ub4dc\uce58\uc758 \uc99d\uac00\ub294 \ud2f0\uc544\uc9c0\ub4dc\uacc4 \uc774\ub1e8\uc81c\uc758 \ud22c\uc5ec\uc640 \uad00\ub828\ub418\uc5b4 \uc788\uc744 \uc218 \uc788\ub2e4. (10) \ud2f0\uc544\uc9c0\ub4dc\uacc4 \uc774\ub1e8\uc81c\ub294 \uc804\uc2e0\uc131 \ud64d\ubc18\uc131 \ub8e8\ud478\uc2a4\ub97c \uc545\ud654 \ud639\uc740 \ud604\uc131\ud654\uc2dc\ud0a8\ub2e4\uace0 \uc54c\ub824\uc838 \uc788\ub2e4. (11) \uae09\uc131 \uadfc\uc2dc \ubc0f 2\ucc28 \ud3d0\uc1c4\uac01 \ub179\ub0b4\uc7a5 : \uc124\ud3f0\uc544\ubbf8\ub4dc\uacc4\uc778 \ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc\ub294 \uae09\uc131 \uc77c\uacfc\uc131 \uadfc\uc2dc \ubc0f \uae09\uc131 \ud3d0\uc1c4\uac01 \ub179\ub0b4\uc7a5\uc744 \uc77c\uc73c\ud0ac \uc218 \uc788\ub2e4. \uc99d\uc0c1\uc774 \ub098\ud0c0\ub0a0 \uacbd\uc6b0 \uac00\ub2a5\ud55c \uc2e0\uc18d\ud558\uac8c \ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc \ud22c\uc5ec\ub97c \uc911\ub2e8\ud55c\ub2e4. \uc548\ub0b4\uc555\uc774 \uc870\uc808\ub418\uc9c0 \uc54a\uc744 \uacbd\uc6b0 \uc2e0\uc18d\ud55c \uc758\ud559\uc801 \ub610\ub294 \uc678\uacfc\uc801 \uce58\ub8cc\ub97c \uace0\ub824\ud574\uc57c \ud55c\ub2e4. 5) \ub85c\uc0ac\ub974\ud0c4 (1) \ub85c\uc0ac\ub974\ud0c4\uc740 \ub808\ub2cc-\uc548\uc9c0\uc624\ud150\uc2e0-\uc54c\ub3c4\uc2a4\ud14c\ub860\uacc4\ub97c \uc5b5\uc81c\ud558\ubbc0\ub85c \ubbfc\uac10\ud55c \ud658\uc790\uc5d0\uc11c\ub294 \uc2e0\uae30\ub2a5\uc758 \ubcc0\ud654\uac00 \uc77c\uc5b4\ub0a0 \uc218 \uc788\ub2e4. \uc77c\ubd80 \ud658\uc790\uc5d0\uc11c \uc774\ub7ec\ud55c \uc2e0\uae30\ub2a5\uc758 \ubcc0\ud654\ub294 \ub85c\uc0ac\ub974\ud0c4\uc758 \ubcf5\uc6a9\uc744 \uc911\ub2e8\ud55c \ud6c4 \uace7 \uc815\uc0c1\uc73c\ub85c \ud68c\ubcf5\ub418\uc5c8\ub2e4. (2) \ud608\uccad \uce7c\ub968 \ub18d\ub3c4\ub97c \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\ub294 \ub2e4\ub978 \uc57d\ubb3c\uacfc\uc758 \ubcd1\uc6a9\uc740 \uace0\uce7c\ub968\ud608\uc99d\uc744 \uc77c\uc73c\ud0ac \uc218 \uc788\ub2e4. \uc774 \uc57d\uc740 \uce7c\ub968\ubcf4\uc874\uc774\ub1e8\uc81c\ub098 \uce7c\ub968\ubcf4\ucda9\uc81c, \uce7c\ub968\uc744 \ud3ec\ud568\ud55c \uc5fc\ubd84 \ub300\uc6a9\uc81c \ub610\ub294 \ud608\uccad \uce7c\ub968 \ub18d\ub3c4\ub97c \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\ub294 \ub2e4\ub978 \uc57d\ubb3c\uacfc\uc758 \ubcd1\uc6a9\ud22c\uc5ec\ub294 \uad8c\uc7a5\ub418\uc9c0 \uc54a\ub294\ub2e4. (3) \uc6a9\ub7c9 \uc870\uc808\uc774 \ud544\uc694\ud55c \uac04\uc7a5\uc560 \ud658\uc790\uc5d0\uac8c \uc0ac\uc6a9\ud558\ub294 \ub85c\uc0ac\ub974\ud0c4\uc758 \uc800\uc6a9\ub7c9\uc744 \uc774 \uc57d\uc73c\ub85c\ub294 \ud22c\uc5ec\ud560 \uc218 \uc5c6\uc73c\ubbc0\ub85c \uc774\ub7ec\ud55c \ud658\uc790\uc5d0 \ub300\ud55c \ud22c\uc5ec\ub294 \uad8c\uc7a5\ub418\uc9c0 \uc54a\ub294\ub2e4. 6) \uc6b4\uc804\uacfc \uae30\uacc4\uc870\uc791 \uc218\ud589\uc5d0 \ub300\ud55c \uc774 \uc57d\uc758 \ud6a8\uacfc\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub294 \uc5c6\uc73c\ub098 \uc6b4\uc804 \ub610\ub294 \uae30\uacc4\uc870\uc791\uc744 \ud560 \ub54c, \ud2b9\ud788 \uce58\ub8cc \uc2dc\uc791 \ub610\ub294 \uc6a9\ub7c9\uc774 \uc99d\uac00\ub418\uc5c8\uc744 \uacbd\uc6b0 \uc5b4\uc9c0\ub7fc \ub610\ub294 \uc878\uc74c\uc774 \ub098\ud0c0\ub0a0 \uc218 \uc788\ub2e4\ub294 \uac83\uc744 \uace0\ub824\ud574\uc57c \ud55c\ub2e4. <strong>[<\/strong><strong>\uc784\ubd80<\/strong><strong> <\/strong><strong>\ubc0f<\/strong><strong> <\/strong><strong>\uc218\uc720\ubd80\uc5d0<\/strong><strong> <\/strong><strong>\ub300\ud55c<\/strong><strong> <\/strong><strong>\ud22c\uc5ec<\/strong><strong>] <\/strong>1) \uc784\ubd80. \ub808\ub2cc-\uc548\uc9c0\uc624\ud150\uc2e0-\uc54c\ub3c4\uc2a4\ud14c\ub860\uacc4\uc5d0 \uc9c1\uc811\uc801\uc73c\ub85c \uc791\uc6a9\ud558\ub294 \uc57d\ubb3c\uad70\uc740 \ubc1c\ub2ec \uc911\uc778 \ud0dc\uc544\uc758 \uc190\uc0c1 \ubc0f \uc0ac\ub9dd\uae4c\uc9c0\ub3c4 \ucd08\ub798\ud560 \uc218 \uc788\ub2e4. \ub85c\uc0ac\ub974\ud0c4\uc740 \uc784\uc2e0 \uc911\uc5d0 \uc0ac\uc6a9\ud574\uc11c\ub294 \uc548\ub418\uba70, \uc784\uc2e0\uc774 \ud655\uc778\ub418\uba74 \uac00\ub2a5\ud55c \ube68\ub9ac \ud22c\uc57d\uc744 \uc911\uc9c0\ud55c\ub2e4. \uc790\uad81 \ub0b4\uc5d0\uc11c \uc548\uc9c0\uc624\ud150\uc2e0 II \uc218\uc6a9\uccb4 \ucc28\ub2e8\uc81c\uc5d0 \ub178\ucd9c\ub41c \uc801\uc774 \uc788\ub294 \uc2e0\uc0dd\uc544, \uc601\u00b7\uc720\uc544\uc758 \uacbd\uc6b0\uc5d0\ub294 \uc800\ud608\uc555, \uc18c\ubcc0\uac10\uc18c\uc99d \ubc0f \uace0\uce7c\ub968\ud608\uc99d\uc774 \uc788\ub294\uc9c0 \uba74\ubc00\ud558\uac8c \uad00\ucc30\ud574\uc57c \ud55c\ub2e4. 2) \uc218\uc720\ubd80. \uc774 \uc57d\uc774 \ubaa8\uc720 \uc911\uc5d0 \ubd84\ube44\ub418\ub294 \uc9c0\uc758 \uc5ec\ubd80\ub294 \ubc1d\ud600\uc9c0\uc9c0 \uc54a\uc558\uc73c\ub098 \ub7ab\ud2b8\uc5d0 \ub300\ud55c \uc2e4\ud5d8\uc5d0\uc11c \uc720\uc999 \uc911\uc5d0 \uc774 \uc57d\uc758 \ubd84\ube44\uac00 \ud655\uc778\ub418\uc5c8\uc73c\ubbc0\ub85c \uc218\uc720\ubd80\uac00 \uc774 \uc57d\uc744 \uc0ac\uc6a9\ud558\ub294 \uac83\uc740 \ubc14\ub78c\uc9c1\ud558\uc9c0 \uc54a\ub2e4. \uc218\uc720\uc911\uc778 \uc5ec\uc131\uc5d0\uac8c \uc774 \uc57d\uc758 \ud22c\uc5ec\ub97c \ud53c\ud558\uace0, \ubd80\ub4dd\uc774 \ud22c\uc5ec\ud558\ub294 \uacbd\uc6b0\uc5d0\ub294 \uc218\uc720\ub97c \uc911\ub2e8\ud574\uc57c \ud55c\ub2e4. <strong>[<\/strong><strong>\uc18c\uc544\uc5d0<\/strong><strong> <\/strong><strong>\ub300\ud55c<\/strong><strong> <\/strong><strong>\ud22c\uc5ec<\/strong><strong>]<\/strong> \uc18c\uc544 \ubc0f \uccad\uc18c\ub144\uc5d0 \ub300\ud55c \uc0ac\uc6a9\uacbd\ud5d8\uc774 \uc5c6\uc73c\ubbc0\ub85c \uc18c\uc544 \ubc0f \uccad\uc18c\ub144\uc5d0\uac8c \uc774 \uc57d\uc744 \ud22c\uc5ec\ud558\uc9c0 \uc54a\ub294\ub2e4. <strong>[<\/strong><strong>\uace0\ub839\uc790\uc5d0<\/strong><strong> <\/strong><strong>\ub300\ud55c<\/strong><strong> <\/strong><strong>\ud22c\uc5ec<\/strong><strong>] <\/strong>\uc88c\uc2ec\uc2e4 \ube44\ub300\ub97c \uac00\uc9c4 \uace0\ud608\uc555 \ud658\uc790\uc5d0 \ub300\ud574 \uc2ec\ud608\uad00 \uc0ac\ub9dd, \ub1cc\uc878\uc911, \uc2ec\uadfc\uacbd\uc0c9\uc758 \ubcf5\ud569 \uc704\ud5d8\ub3c4 \uac10\uc18c\ub97c \ud655\uc778\ud558\uae30 \uc704\ud55c \ub300\uc870 \uc784\uc0c1\uc2dc\ud5d8\uc5d0\uc11c 2,857\uba85(62%)\uc758 \ud658\uc790\uac00 65\uc138 \uc774\uc0c1\uc774\uc5c8\uc73c\uba70 808(18%)\uba85\uc758 \ud658\uc790\uac00 75\uc138 \uc774\uc0c1\uc774\uc5c8\ub2e4. \uc774 \uc2dc\ud5d8\uc5d0\uc11c \ud658\uc790\ub4e4\uc740 \ud608\uc555\uc744 \uc870\uc808\ud558\uae30 \uc704\ud574 \ub85c\uc0ac\ub974\ud0c4\uacfc \ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc\ub97c \uc5f0\uad6c\uc57d \ubcf5\uc6a9 \uae30\uac04\uc758 74% \ub3d9\uc548 \ubcd1\uc6a9\ud22c\uc5ec \ubc1b\uc558\ub2e4. \uace0\ub839\uc790\uc640 \uc80a\uc740 \ud658\uc790\ub4e4 \uc0ac\uc774\uc5d0 \uc720\ud6a8\uc131\uc5d0 \ub300\ud55c \uc804\ubc18\uc801 \ucc28\uc774\ub294 \uc5c6\uc5c8\uc73c\ub098 \uc774\uc0c1\ubc18\uc751\uc740 \ub85c\uc0ac\ub974\ud0c4-\ud788\ub4dc\ub85c\ud074\ub85c\ub85c\ud2f0\uc544\uc9c0\ub4dc\uad70\uacfc \ub300\uc870\uad70 \ubaa8\ub450\uc5d0\uc11c \ube44\uace0\ub839\uc790\uc5d0 \ube44\ud574 \uace0\ub839\uc790\uc5d0\uc11c \ub2e4\uc18c \ub354 \ube48\ubc88\ud558\uac8c \ub098\ud0c0\ub0ac\ub2e4. \uac1c\uc815\ub144\uc6d4\uc77c : 2025\ub144 10\uc6d4 20\uc77c<\/p>\n\n\n\n<p><strong>\u203b<\/strong><strong> \ucc98\ubc29\ud558\uc2dc\uae30 \uc804\uc5d0 \uc81c\ud488\uc124\uba85\uc11c\ub97c \ucc38\uace0\ud558\uc2dc\uae30 \ubc14\ub78d\ub2c8\ub2e4<\/strong><strong>.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-color\" id=\"h-selective-safety-information-\ucf54\uc790-\uc5d1\uc2a4\ud050\uc815-\ub85c\uc0ac\ub974\ud0c4\uce7c\ub968-\uc554\ub85c\ub514\ud540-\uce84\uc2e4\uc0b0\uc5fc-5-50-mg-5-100mg-10-50mg\" style=\"color:#0085cd\"><strong><strong>Selected Safety Information \ucf54\uc790<sup>\u00ae<\/sup>\uc5d1\uc2a4\ud050\uc815 (\ub85c\uc0ac\ub974\ud0c4\uce7c\ub968-\uc554\ub85c\ub514\ud540 \uce84\uc2e4\uc0b0\uc5fc) 5\/50 mg, 5\/100 mg, 10\/50 mg<\/strong><\/strong><\/h2>\n\n\n\n<p class=\"has-text-align-left\"><strong>[<\/strong><strong>\ud6a8\ub2a5\u00b7\ud6a8\uacfc<\/strong><strong>] <\/strong>1. \uc554\ub85c\ub514\ud540 \ub610\ub294 \ub85c\uc0ac\ub974\ud0c4 \ub2e8\ub3c5\uc694\ubc95\uc73c\ub85c \ud608\uc555\uc774 \uc801\uc808\ud558\uac8c \uc870\uc808\ub418\uc9c0 \uc54a\ub294 \ubcf8\ud0dc\uc131 \uace0\ud608\uc555. 2. \uc81c2\uae30 \uace0\ud608\uc555 \ud658\uc790\uc5d0\uc11c \uce58\ub8cc \ubaa9\ud45c \ud608\uc555\uc5d0 \ub3c4\ub2ec\ud558\uae30 \uc704\ud574 \ubcf5\ud569\uc81c \ud22c\uc5ec\uac00 \ud544\uc694\ud55c \ud658\uc790\uc758 \ucd08\uae30\uc694\ubc95<strong> [<\/strong><strong>\uc6a9\ubc95\u00b7\uc6a9\ub7c9<\/strong><strong>] <\/strong>\uc774 \uc57d\uc758 \uad8c\uc7a5\uc6a9\ub7c9\uc740 1\uc77c 1\ud68c 1\uc815\uc73c\ub85c, \uc2dd\uc0ac\uc640 \uad00\uacc4\uc5c6\uc774 \ubb3c\uacfc \ud568\uaed8 \ubcf5\uc6a9\ud55c\ub2e4. \uac00\ub2a5\ud558\uba74 \ub9e4\uc77c \uac19\uc740 \uc2dc\uac04\uc5d0 \ubcf5\uc6a9\ud560 \uac83\uc774 \uad8c\uc7a5\ub41c\ub2e4. \uc774 \uc57d\uc744 \ud22c\uc5ec\ud558\uae30 \uc804\uc5d0 \uac1c\uac1c\uc758 \uc131\ubd84 (\uc554\ub85c\ub514\ud540 \ub610\ub294 \ub85c\uc0ac\ub974\ud0c4)\uc73c\ub85c \uc6a9\ub7c9\uc744 \uc870\uc808\ud560 \uac83\uc774 \uad8c\uc7a5\ub418\ub098, \ub2e4\uc74c\uacfc \uac19\uc774 \uac1c\uac1c\uc758 \uc131\ubd84\uc5d0 \ub300\ud55c \ub2e8\ub3c5\uc694\ubc95\uc73c\ub85c \ud608\uc555\uc774 \uc870\uc808\ub418\uc9c0 \uc54a\ub294 \uacbd\uc6b0 \uc774 \uc57d\uc73c\ub85c \ubc14\ub85c \uc804\ud658\ud558\ub294 \uac83\uc744 \uace0\ub824\ud560 \uc218 \uc788\ub2e4. \uc554\ub85c\ub514\ud540\uacfc \ub85c\uc0ac\ub974\ud0c4\uc744 \ubcd1\uc6a9\uc73c\ub85c \ubcf5\uc6a9\ud558\uace0 \uc788\ub294 \ud658\uc790\uc778 \uacbd\uc6b0, \ubcf5\uc6a9\uc758 \ud3b8\ub9ac\ud568\uc744 \uc704\ud558\uc5ec \uc774 \uc57d(\uac1c\uac1c\uc758 \uc8fc\uc131\ubd84 \ud568\ub7c9\uc774 \ub3d9\uc77c\ud55c \ubcf5\ud569\uc81c)\uc73c\ub85c \uc804\ud658\ud560 \uc218 \uc788\ub2e4. \uc81c2\uae30 \uace0\ud608\uc555 \ud658\uc790\uc5d0\uac8c \uc774 \uc57d\uc744 \ucd08\uae30\uc694\ubc95\uc73c\ub85c \ud22c\uc5ec\ud558\uae30 \uc804\uc5d0, \uae30\uc800\uce58 \ud608\uc555, \uce58\ub8cc \ubaa9\ud45c \ud608\uc555, \ub2e8\uc77c\uc81c \ub300\ube44 \ubcf5\ud569\uc81c\uc758 \uc608\uc0c1 \uce58\ub8cc\ubaa9\ud45c \ub3c4\ub2ec \uc815\ub3c4 \ub4f1\uc744 \uace0\ub824\ud558\uc5ec \ud22c\uc5ec \uc5ec\ubd80\ub97c \uacb0\uc815\ud574\uc57c \ud55c\ub2e4. \ud1b5\uc0c1 \uc774 \uc57d 5\/50 \ubc00\ub9ac\uadf8\ub7a8\uc744 1\uc77c 1\ud68c \ud22c\uc5ec\ud558\uba70, 2\uc8fc\uac04 \ud22c\uc5ec \ud6c4\uc5d0\ub3c4 \ud608\uc555\uc774 \ucda9\ubd84\ud788 \uc870\uc808\ub418\uc9c0 \uc54a\ub294 \uacbd\uc6b0, 1\uc77c 1\ud68c 10\/50\ubc00\ub9ac\uadf8\ub7a8\uc73c\ub85c \uc99d\ub7c9\ud560 \uc218 \uc788\ub2e4. <strong>[<\/strong><strong>\uacbd\uace0]<\/strong> 1) \uc784\ubd80\uc5d0\uac8c \ub808\ub2cc-\uc548\uc9c0\uc624\ud150\uc2e0-\uc54c\ub3c4\uc2a4\ud14c\ub860\uacc4 (RAAS)\uc5d0 \uc9c1\uc811 \uc791\uc6a9\ud558\ub294 \uc57d\ubb3c\ub4e4\uc758 \ud22c\uc5ec \uc2dc, \ud0dc\uc544 \ubc0f \uc2e0\uc0dd\uc544\uc5d0\uac8c \uc190\uc0c1 \ubc0f \uc0ac\ub9dd\uae4c\uc9c0\ub3c4 \uc77c\uc5b4\ub0a0 \uc218 \uc788\ub2e4. \uc591\uc218\uacfc\uc18c\uc99d\uc758 \ubc1c\uc0dd\uc740 \ud0dc\uc544\uc758 \ud3d0 \ud615\uc131 \uc800\ud558\uc99d \ubc0f \uace8\uaca9 \uae30\ud615\uacfc \uad00\ub828\uc774 \uc788\uc744 \uc218 \uc788\ub2e4. \uc2e0\uc0dd\uc544\uc5d0\uac8c \ub098\ud0c0\ub0a0 \uac00\ub2a5\uc131\uc774 \uc788\ub294 \ubd80\uc791\uc6a9\uc740 \ub450\uac1c\uace8 \ud615\uc131 \uc800\ud558\uc99d, \ubb34\ub1e8\uc99d, \uc800\ud608\uc555, \uc2e0\ubd80\uc804\uacfc \uc0ac\ub9dd \ub4f1\uc744 \ud3ec\ud568\ud55c\ub2e4. \uc784\uc2e0\uc774 \ud655\uc778\ub418\uba74 \uac00\ub2a5\ud55c \ube68\ub9ac \uc774 \uc57d\uc744 \uc911\ub2e8\ud574\uc57c \ud55c\ub2e4. 2) \ud608\uad00 \ub0b4 \uc720\ud6a8 \ud608\uc561\ub7c9 \uac10\uc18c \ud658\uc790. \ub85c\uc0ac\ub974\ud0c4\uc758 \uacbd\uc6b0 \ud608\uad00 \ub0b4 \uc720\ud6a8 \ud608\uc561\ub7c9 \uac10\uc18c (intravascular volume depletion) \ud658\uc790 (\uc608\ub97c \ub4e4\uc5b4, \uc774\ub1e8\uc81c\ub97c \ud22c\uc5ec \ubc1b\uace0 \uc788\ub294 \ud658\uc790)\uc5d0 \uc774 \uc57d\uc744 \ucc98\uc74c \ud22c\uc5ec\ud558\uc600\uc744 \ub54c \uc800\ud608\uc555 \uc99d\uc0c1\uc774 \ub098\ud0c0\ub0a0 \uc218 \uc788\uc73c\ubbc0\ub85c, \uc774 \uc57d \ud22c\uc5ec \uc804\uc5d0 \uc774\ub7ec\ud55c \uc99d\uc0c1\ub4e4\uc744 \uce58\ub8cc\ud574\uc57c \ud55c\ub2e4. \ub9cc\uc57d, \ub85c\uc0ac\ub974\ud0c4 1\uc77c 1\ud68c 25 mg \ud22c\uc5ec\uac00 \uad8c\uc7a5\ub418\ub294 \uacbd\uc6b0, \uc774 \uc57d\uc73c\ub85c\ub294 \ub85c\uc0ac\ub974\ud0c4 25 mg \ud22c\uc5ec\uac00 \uac00\ub2a5\ud558\uc9c0 \uc54a\uc73c\ubbc0\ub85c, \uc774\ub7ec\ud55c \ud658\uc790\uc5d0 \ub300\ud558\uc5ec \ud22c\uc5ec\ud558\uc9c0 \uc54a\ub3c4\ub85d \ud55c\ub2e4. <strong>[\uae08\uae30]<\/strong> 1) \uc774 \uc57d\uc758 \uc8fc\uc131\ubd84 \ubc0f \ub514\ud788\ub4dc\ub85c\ud53c\ub9ac\ub518\uacc4 \uc720\ub3c4\uccb4\uc5d0 \uacfc\ubbfc\uc99d\uc774 \uc788\ub294 \ud658\uc790 2) \uc784\ubd80 \ub610\ub294 \uc784\uc2e0\ud558\uace0 \uc788\uc744 \uac00\ub2a5\uc131\uc774 \uc788\ub294 \uc5ec\uc131 3) \uc911\uc99d\uc758 \uac04\uae30\ub2a5 \uc7a5\uc560 \ud658\uc790 4) \uc911\uc99d\uc758 \ub300\ub3d9\ub9e5\ud310\ud611\ucc29\uc99d \ud658\uc790 5) \uc1fd \ud658\uc790 6) \ub2f9\ub1e8\ubcd1\uc774\ub098 \uc911\ub4f1\ub3c4~\uc911\uc99d\uc758 \uc2e0\uc7a5\uc560 \ud658\uc790 (\uc0ac\uad6c\uccb4\uc5ec\uacfc\uc728 &lt;60 mL\/min\/1.73m<sup>2<\/sup>)\uc5d0\uc11c \uc54c\ub9ac\uc2a4\ud0a4\ub80c \ud568\uc720\uc81c\uc81c\uc640\uc758 \ubcd1\uc6a9<strong> [\uc2e0\uc911\ud22c\uc5ec] <\/strong>1) \ud608\uad00 \ub0b4 \uc720\ud6a8 \ud608\uc561\ub7c9 \uac10\uc18c \ud658\uc790 (\uc608, \uc774\ub1e8\uc81c \ud22c\uc5ec \uc911\uc778 \ud658\uc790) 2) \uc5c4\uaca9\ud55c \uc5fc\ubd84\uc81c\ud55c \ud658\uc790 3) \uc911\ub4f1\ub3c4\u223c\uc911\uc99d \uc2e0\uc7a5\uc560 \ud658\uc790 (\uc608, creatinine clearance &lt; 20 mL\/min) \ubc0f \ud22c\uc11d \ud658\uc790 4) \uace0\uce7c\ub968\ud608\uc99d \ud658\uc790 5) \ub808\ub2cc-\uc548\uc9c0\uc624\ud150\uc2e0-\uc54c\ub3c4\uc2a4\ud14c\ub860\uacc4(RAAS)\uc758 \uc774\uc911\ucc28\ub2e8 : \uc548\uc9c0\uc624\ud150\uc2e0 \uc218\uc6a9\uccb4 \ucc28\ub2e8\uc81c(ARB), ACE \uc5b5\uc81c\uc81c, \ub610\ub294 \uc54c\ub9ac\uc2a4\ud0a4\ub80c \ub4f1 \ub808\ub2cc-\uc548\uc9c0\uc624\ud150\uc2e0-\uc54c\ub3c4\uc2a4\ud14c\ub860\uacc4(RAAS)\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \ub2e4\ub978 \uc57d\uc81c\uc640\uc758 \ubcd1\uc6a9\uc740 \uad8c\uc7a5\ub418\uc9c0 \uc54a\ub294\ub2e4.<strong> [\uc774\uc0c1\ubc18\uc751] <\/strong>1) \uc774 \uc57d (\uc554\ub85c\ub514\ud540\/\ub85c\uc0ac\ub974\ud0c4 \ubcf5\ud569\uc81c)\uc5d0 \ub300\ud55c \uc548\uc804\uc131\uc740 \ubcf8\ud0dc\uace0\ud608\uc555 \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c 8\uc8fc\uac04 \ud22c\uc5ec\ud55c 3\uac1c\uc758 \uc784\uc0c1\uc2dc\ud5d8 (\uc784\uc0c1\uc2dc\ud5d8 201, \uc784\uc0c1\uc2dc\ud5d8 301 \ubc0f \uc784\uc0c1\uc2dc\ud5d8 302) \ubc0f stage 2 \uace0\ud608\uc555 \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c 8\uc8fc\uac04 \ud22c\uc5ec\ud55c \uc784\uc0c1\uc2dc\ud5d8 303 \uc744 \ud1b5\ud574, \ucd1d 794\uba85\uc758 \uace0\ud608\uc555 \ud658\uc790 \uc911 \uc554\ub85c\ub514\ud540\/\ub85c\uc0ac\ub974\ud0c4 \ubcf5\ud569\uc81c\ub97c \ud22c\uc5ec \ubc1b\uc740 398\uba85\uc744 \ub300\uc0c1\uc73c\ub85c \ud3c9\uac00\ub418\uc5c8\ub2e4. \uc774\uc0c1\ubc18\uc751\uc5d0 \ub300\ud55c \ubc1c\ud604\ube48\ub3c4\ub294 \ub2e4\uc74c\uacfc \uac19\ub2e4. [\uc2e0\uacbd\uacc4] \uc5b4\uc9c0\ub7ec\uc6c0, \ub450\ud1b5, \uc878\uc74c, \ub1cc\uacbd\uc0c9 [\uc804\uc2e0 \uc774\uc0c1 \ubc0f \ud22c\uc5ec\ubd80\uc704 \ubc18\uc751] \ubb34\ub825\uc99d, \ud749\ubd80 \ubd88\ud3b8\uac10, \ud749\ud1b5, \uc870\uae30\ud3ec\ub9cc\uac10, \ub9d0\ucd08\ubd80\uc885, \uc624\ubaa9\ubd80\uc885 [\uc704\uc7a5\uad00 \uc774\uc0c1] \ubcf5\ubd80 \ubd88\ud3b8\uac10, \uc18c\ud654\ubd88\ub7c9, \uad6c\uc5ed, \uc5ed\ub958\uc131 \uc2dd\ub3c4\uc5fc, \ubcc0\ube44 [\ud53c\ubd80 \ubc0f \ud53c\ud558\uc870\uc9c1 \uc774\uc0c1] (\uc804\uc2e0\uc131)\uac00\ub824\uc6c0\uc99d, \uc804\uc2e0\uc131 \ub450\ub4dc\ub7ec\uae30 [\uc2ec\uc7a5\uc774\uc0c1] \uc2ec\uacc4\ud56d\uc9c4 [\ud608\uad00\uc774\uc0c1] \ud64d\uc870, \uae30\ub9bd\uc131 \uc800\ud608\uc555, \uc548\uba74\ud64d\uc870 [\ud638\ud761\uae30\uacc4, \ud749\ubd80 \ubc0f \uc885\uaca9 \uc774\uc0c1] \ud638\ud761\uace4\ub780, \uae30\uce68 [\uac10\uac01\uae30\uad00 \uc774\uc0c1] \uc5b4\uc9c0\ub7ec\uc6c0, \uc548\uad6c\ucda9\ud608 [\uc2e0\uc7a5 \ubc0f \ubc29\uad11 \uc774\uc0c1] \ube48\ub1e8. (2) \uad6d\ub0b4 \uc2dc\ud310 \ud6c4 \uc870\uc0ac. \uad6d\ub0b4\uc5d0\uc11c \uc7ac\uc2ec\uc0ac\ub97c \uc704\ud558\uc5ec 6\ub144 \ub3d9\uc548 658\uba85\uc744 \ub300\uc0c1\uc73c\ub85c \uc2e4\uc2dc\ud55c \uc2dc\ud310 \ud6c4 \uc870\uc0ac \uacb0\uacfc, \uc774\uc0c1\uc0ac\ub840\uc758 \ubc1c\ud604\uc728\uc740 \uc778\uacfc\uad00\uacc4\uc640 \uc0c1\uad00\uc5c6\uc774 3.19% (21\/658\uba85, \ucd1d 25 \uac74)\ub85c \ubcf4\uace0\ub418\uc5c8\ub2e4. \uc774 \uc911 \uc911\ub300\ud55c \uc774\uc0c1\uc0ac\ub840\uc758 \ubc1c\ud604\uc728\uc740 0.46%(3\/658\uba85, 4\uac74)\ub85c \uad00\uc808\ud1b5, \uc218\uba74 \ubb34\ud638\ud761 \uc99d\ud6c4\uad70, \uc790\uad81\uc12c\uc720\uc885, \uc790\uad81\ud0c8\ucd9c \uac01 0.15% (1\/658\uba85, 1\uac74), \uc774 \uc57d\uacfc \uc778\uacfc\uad00\uacc4\ub97c \ubc30\uc81c\ud560 \uc218 \uc5c6\ub294 \uc911\ub300\ud55c \uc774\uc0c1\uc0ac\ub840\ub294 \ubcf4\uace0\ub418\uc9c0 \uc54a\uc558\ub2e4. 2) \ub85c\uc0ac\ub974\ud0c4\uc5d0 \ub300\ud55c \uc2dc\ud310 \ud6c4 \ucd94\uac00 \ubcf4\uace0 (1) \uacfc\ubbfc\ubc18\uc751 : \ud608\uad00\ubd80\uc885(\uae30\ub3c4 \ud3d0\uc1c4\ub97c \uc57c\uae30\ud560 \uc218 \uc788\ub294 \ud6c4\ub450\/\uc131\ubb38\uc758 \ud33d\uc724, \uc5bc\uad74\/\uc785\uc220\/\uc778\ub450\/\ud600\uc758 \ud33d\uc724)\uc774 \ub85c\uc0ac\ub974\ud0c4\uc744 \ud22c\uc5ec\ubc1b\uc740 \ud658\uc790\uc5d0\uc11c \ub4dc\ubb3c\uac8c \ubcf4\uace0\ub418\uc5c8\uc73c\uba70, \uc774\ub4e4 \uc774\uc0c1\ubc18\uc751\uc744 \ubcf4\uc778 \ud658\uc790 \uc911 \uc77c\ubd80\ub294 \uc774\uc804\uc5d0 ACE \uc5b5\uc81c\uc81c \ub4f1\uc758 \ub2e4\ub978 \uc57d\uc81c\uc5d0 \ub300\ud574\uc11c\ub3c4 \ud608\uad00\ubd80\uc885\uc744 \uacbd\ud5d8\ud55c \uc801\uc774 \uc788\uc5c8\ub2e4. \uc7a5 \ud608\uad00 \ubd80\uc885\uc740 \ub85c\uc0ac\ub974\ud0c4\uc744 \ube44\ub86f\ud55c \uc548\uc9c0\uc624\ud150\uc2e0 II \uc218\uc6a9\uccb4 \ucc28\ub2e8\uc81c\ub85c \uce58\ub8cc\ubc1b\uc740 \ud658\uc790\uc5d0\uc11c \ubcf4\uace0\ub41c \ubc14 \uc788\ub2e4. \ud608\uad00\uc5fc(Henoch- Sch\u00f6nlein \uc790\ubc18\ubcd1)\uacfc \uc544\ub098\ud544\ub77d\uc2dc\uc131 \ubc18\uc751\uc774 \ubcf4\uace0\ub41c \uc801\uc774 \uc788\ub2e4.&nbsp;<strong>[\uc77c\ubc18\uc801 \uc8fc\uc758]<\/strong> 1) \ud608\uc555\uac15\ud558\uc791\uc6a9\uc5d0 \uc758\ud55c \uc5b4\uc9c0\ub7ec\uc6c0\uc774 \ub098\ud0c0\ub0a0 \uc218 \uc788\uc73c\ubbc0\ub85c \uace0\uc18c\uc791\uc5c5, \uc790\ub3d9\ucc28\uc6b4\uc804 \ub4f1 \uc704\ud5d8\uc774 \uc218\ubc18\ub418\ub294 \uae30\uacc4\uc870\uc791\uc744 \ud558\uc9c0 \uc54a\ub3c4\ub85d \uc8fc\uc758\ud55c\ub2e4. 2) \uc554\ub85c\ub514\ud540\uc758 \uacbd\uc6b0 \ud608\uc7a5\ub18d\ub3c4 \ubc18\uac10\uae30\uac00 \uae38\uc5b4 \ud22c\uc5ec\ub97c \uc911\uc9c0\ud55c \ud6c4\uc5d0\ub3c4 \uc644\ub9cc\ud55c \ud608\uc555\uac15\ud558\uc791\uc6a9\uc774 \ub098\ud0c0\ub098\ubbc0\ub85c, \ud22c\uc5ec\uc911\uc9c0 \ud6c4 \ub2e4\ub978 \ud608\uc555\uac15\ud558\uc81c\ub97c \ud22c\uc5ec\ud558\ub294 \uacbd\uc6b0\uc5d0\ub294 \uc6a9\ub7c9 \ubc0f \ud22c\uc5ec\uac04\uaca9\uc5d0 \uc8fc\uc758\ud558\uace0 \ud658\uc790\uc758 \uc0c1\ud0dc\ub97c \uad00\ucc30\ud558\uba74\uc11c \uc2e0\uc911\ud788 \ud22c\uc5ec\ud55c\ub2e4. 3) \uacfc\ubbfc\ubc18\uc751: \ud608\uad00\ubd80\uc885 (4. \uc774\uc0c1\ubc18\uc751 \ud56d \ucc38\uc870) 4) \uc7a5 \ud608\uad00 \ubd80\uc885\uc774 \uc548\uc9c0\uc624\ud150\uc2e0 \u2161 \uc218\uc6a9\uccb4 \ucc28\ub2e8\uc81c\ub97c \ud22c\uc5ec\ubc1b\uc740 \ud658\uc790\uc5d0\uc11c \ubcf4\uace0\ub418\uc5c8\ub2e4. \ubcf5\ud1b5, \uba54\uc2a4\uaebc\uc6c0, \uad6c\ud1a0 \ubc0f \uc124\uc0ac\uac00 \ubcf4\uace0\ub418\uc5c8\uace0, \ud22c\uc5ec \uc911\ub2e8 \ud6c4 \uc99d\uc0c1\uc774 \uc644\ud654\ub418\uc5c8\ub2e4. \uc7a5 \ud608\uad00 \ubd80\uc885\uc774 \ud655\uc778\ub418\uba74 \ud22c\uc5ec\ub97c \uc911\ub2e8\ud558\uace0 \uc99d\uc0c1\uc774 \uc644\ud654\ub420 \ub54c\uae4c\uc9c0 \uc801\uc808\ud788 \ubaa8\ub2c8\ud130\ub9c1 \ud574\uc57c \ud55c\ub2e4. 5) \uac04\uc7a5\uc560 \ud658\uc790 : \uac04\uacbd\ubcc0\uc99d \ud658\uc790\uc758 \ud608\uc7a5 \ub85c\uc0ac\ub974\ud0c4 \ub18d\ub3c4\uac00 \ud604\uc800\ud788 \uc0c1\uc2b9\ub418\uc5c8\ub2e4\ub294 \ubcf4\uace0\uac00 \uc788\uc73c\ubbc0\ub85c, \uac04\uae30\ub2a5 \uc7a5\uc560\uac00 \uc788\ub294 \ud658\uc790 \uc911 \ub85c\uc0ac\ub974\ud0c4\uc758 \ud22c\uc5ec\uc6a9\ub7c9 \uac10\ub7c9\uc774 \uc694\uad6c\ub418\ub294 \uacbd\uc6b0 \uc774 \uc57d\uc758 \ud22c\uc5ec\uac00 \uad8c\uc7a5\ub418\uc9c0 \uc54a\ub294\ub2e4. 6) \uc2e0\uc7a5\uc560 \ud658\uc790 : \ub808\ub2cc-\uc548\uc9c0\uc624\ud150\uc2e0-\uc54c\ub3c4\uc2a4\ud14c\ub860\uacc4\uc5d0 \ub300\ud55c \uc601\ud5a5\uc758 \uacb0\uacfc, \uc2e0\uae30\ub2a5\uc758 \ubcc0\ud654\uac00 \ubcf4\uace0\ub418\uc5c8\ub2e4. \uc774\ub7ec\ud55c \uc2e0\uae30\ub2a5\uc758 \ubcc0\ud654\ub294 \ud22c\uc5ec \uc911\ub2e8 \uc2dc \uc815\uc0c1\uc73c\ub85c \ud68c\ubcf5\ub418\uc5c8\ub2e4. \uc2e0\uae30\ub2a5\uc774 \ub808\ub2cc-\uc548\uc9c0\uc624\ud150\uc2e0-\uc54c\ub3c4\uc2a4\ud14c\ub860\uacc4\uc5d0 \uc758\uc874\uc801\uc778 \ud658\uc790\uc758 \uacbd\uc6b0(\uc608, \uc911\uc99d\uc758 \uc6b8\ud608\uc131 \uc2ec\ubd80\uc804 \ud658\uc790), ACE \uc5b5\uc81c\uc81c\ub97c \ud22c\uc5ec\ud558\uc600\uc744 \ub54c, \ube48\ub1e8 \ubc0f\/\ud639\uc740 \uc9c4\ud589\uc131 \uc9c8\uc18c\ud608\uc99d\uc774 \ubcf4\uace0\ub418\uc5c8\uc73c\uba70, (\ub4dc\ubb3c\uac8c) \uae09\uc131 \uc2e0\ubd80\uc804 \ubc0f\/\ud639\uc740 \uc0ac\ub9dd\uc774 \ubcf4\uace0\ub418\uc5c8\ub2e4. \uc720\uc0ac\ud55c \uacb0\uacfc\uac00 \ub85c\uc0ac\ub974\ud0c4\uc744 \ud22c\uc5ec\ud55c \ud658\uc790\uc5d0\uc11c\ub3c4 \ubcf4\uace0\ub418\uc5c8\ub2e4. ACE \uc5b5\uc81c\uc81c\uac00 \uc591\uce21\uc131 \ud639\uc740 \ud3b8\uce21\uc131 \uc2e0\ub3d9\ub9e5 \ud611\ucc29\uc99d\uc744 \uac16\ub294 \ud658\uc790\ub4e4\uc758 \ud608\uc911 \uc694\uc18c\uc640 \ud608\uccad \ud06c\ub808\uc544\ud2f0\ub2cc\uce58\ub97c \uc0c1\uc2b9\uc2dc\ucf30\ub2e4\ub294 \ubcf4\uace0\uac00 \uc788\ub2e4. \ub85c\uc0ac\ub974\ud0c4\uc744 \ud22c\uc5ec\ud55c \ud658\uc790\uc5d0\uc11c\ub3c4 \uc720\uc0ac\ud55c \uacb0\uacfc\uac00 \ubcf4\uace0\ub418\uc5c8\ub2e4.: \uc774\ub294 \ud22c\uc5ec \uc911\ub2e8\uc2dc \ud68c\ubcf5\ub418\uc5c8\ub2e4. 7) \uace0\uce7c\ub968\ud608\uc99d(\ud608\uccad \uce7c\ub968 &gt;5.5 mmol\/L)\uc774 \ub85c\uc0ac\ub974\ud0c4 \ub2e8\uc77c\uc81c \ud22c\uc5ec\ud658\uc790 \uc911 1.5%\uc758 \ud658\uc790\uc5d0\uac8c\uc11c \ubc1c\uc0dd\ud558\uc600\uc73c\ub098 \uc57d\ubb3c\ud22c\uc5ec\ub97c \uc911\ub2e8\ud560 \uc815\ub3c4\ub294 \uc544\ub2c8\uc5c8\ub2e4. \ud608\uccad \uce7c\ub968 \ub18d\ub3c4\ub97c \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\ub294 \ub2e4\ub978 \uc57d\ubb3c\uacfc\uc758 \ubcd1\uc6a9\uc740 \uace0\uce7c\ub968\ud608\uc99d\uc744 \uc77c\uc73c\ud0ac \uc218 \uc788\ub2e4. \uc774 \uc57d\uacfc \uce7c\ub968\ubcf4\uc874\uc774\ub1e8\uc81c, \uce7c\ub968\ubcf4\ucda9\uc81c, \uce7c\ub968\uc744 \ud568\uc720\ud55c \uc5fc\ubd84 \ub300\uc6a9\uc81c \ub610\ub294 \uce7c\ub968 \uc218\uce58\ub97c \uc0c1\uc2b9\uc2dc\ud0ac \uc218 \uc788\ub294 \ub2e4\ub978 \uc57d\ubb3c\uacfc \ubcd1\uc6a9 \uc2dc(\ud2b9\ud788, \ub178\uc778\uacfc \uc2e0\uc7a5\uc560 \ud658\uc790)\uc5d0\ub294 \uc8fc\uc758\ud558\uc5ec\uc57c \ud558\uba70, \uce7c\ub968 \uc218\uce58\ub97c \uc8fc\uc758\uae4a\uac8c \ubaa8\ub2c8\ud130\ub9c1 \ud574\uc57c \ud55c\ub2e4(6. \uc0c1\ud638\uc791\uc6a9 \ud56d \ucc38\uc870) 8) \ub85c\uc0ac\ub974\ud0c4\uc758 \ud22c\uc5ec\ub85c \uc778\ud574 \uc77c\uacfc\uc131\uc758 \ud608\uc555\uc800\ud558(\uc1fd\uc99d\uc0c1, \uc758\uc2dd\uc0c1\uc2e4, \ud638\ud761\uace4\ub780 \ub4f1\uc744 \ub3d9\ubc18)\ub97c \uc77c\uc73c\ud0ac \uc218 \uc788\uc73c\ubbc0\ub85c \uadf8\ub7ec\ud55c \uacbd\uc6b0\uc5d0\ub294 \ud22c\uc5ec\ub97c \uc911\uc9c0\ud558\uace0 \uc801\uc808\ud55c \ucc98\uce58\ub97c \ud55c\ub2e4. \ud2b9\ud788, \ub2e4\uc74c \ud658\uc790\uc5d0 \ud22c\uc5ec \uc2dc \ud658\uc790\uc758 \uc0c1\ud0dc\ub97c \ucda9\ubd84\ud788 \uad00\ucc30\ud558\uc5ec\uc57c \ud558\uba70, \ub9cc\uc57d, \ub85c\uc0ac\ub974\ud0c4 1\uc77c 1\ud68c 25 mg \ud22c\uc5ec\uac00 \uad8c\uc7a5\ub418\ub294 \uacbd\uc6b0, \uc774 \uc57d\uc73c\ub85c\ub294 \ub85c\uc0ac\ub974\ud0c4 25 mg \ud22c\uc5ec\uac00 \uac00\ub2a5\ud558\uc9c0 \uc54a\uc73c\ubbc0\ub85c, \uc774\ub7ec\ud55c \ud658\uc790\uc5d0 \ub300\ud574 \ud22c\uc5ec\ud558\uc9c0 \uc54a\ub3c4\ub85d \ud55c\ub2e4. &#8211; \ud608\uad00 \ub0b4 \uc720\ud6a8 \ud608\uc561\ub7c9 \uac10\uc18c \ud658\uc790 (\uc608, \uc774\ub1e8\uc81c \ud22c\uc5ec\uc911\uc778 \ud658\uc790) &#8211; \uc5c4\uaca9\ud55c \uc5fc\ubd84\uc81c\ud55c \ud658\uc790 &#8211; \uc911\ub4f1\ub3c4 \u223c \uc911\uc99d \uc2e0\uc7a5\uc560 \ud658\uc790(\uc608, creatinine clearance : 20 mL\/min \ubbf8\ub9cc) \ubc0f \ud22c\uc11d \ud658\uc790 <strong>[\uc0c1\ud638\uc791\uc6a9]<\/strong> \ub2e4\ub978 \ud608\uc555\uac15\ud558\uc81c\uc640 \ubcd1\uc6a9\ud558\ub294 \uacbd\uc6b0\uc5d0\ub294 \uc791\uc6a9\uc774 \uc99d\uac15\ub420 \uc218 \uc788\uc73c\ubbc0\ub85c \uc2e0\uc911\ud788 \ud22c\uc5ec\ud55c\ub2e4. <strong>[\uc784\ubd80 \ubc0f \uc218\uc720\ubd80\uc5d0 \ub300\ud55c \ud22c\uc5ec<\/strong>] 1) \uc784\ubd80 (1) \uc554\ub85c\ub514\ud540\uc758 \uc784\ubd80\uc5d0 \ub300\ud55c \uc548\uc804\uc131\uc740 \ud655\ub9bd\ub418\uc9c0 \uc54a\uc558\ub2e4. \uc778\uccb4\uc5d0 \ub300\ud55c \ucd5c\ub300 \uad8c\uc7a5\uc6a9\ub7c9\uc758 50\ubc30\uc5d0 \ud574\ub2f9\ud558\ub294 \uc6a9\ub7c9\uc758 \uc554\ub85c\ub514\ud540\uc744 \ud22c\uc5ec\ud55c \ub7ab\ud2b8\uc5d0\uc11c \ubd84\ub9cc\uc9c0\uc5f0 \ubc0f \uc5f0\uc7a5\uc774 \ub098\ud0c0\ub0ac\ub2e4. (2) \ub808\ub2cc-\uc548\uc9c0\uc624\ud150\uc2e0-\uc54c\ub3c4\uc2a4\ud14c\ub860\uacc4\uc5d0 \uc9c1\uc811\uc801\uc73c\ub85c \uc791\uc6a9\ud558\ub294 \uc57d\ubb3c\uad70\uc740 \ubc1c\ub2ec \uc911\uc778 \ud0dc\uc544\uc758 \uc190\uc0c1 \ubc0f \uc0ac\ub9dd\uae4c\uc9c0\ub3c4 \ucd08\ub798\ud560 \uc218 \uc788\ub2e4. \ub85c\uc0ac\ub974\ud0c4\uc740 \uc784\uc2e0 \uc911\uc5d0 \uc0ac\uc6a9\ud574\uc11c\ub294 \uc548 \ub418\uba70, \uc784\uc2e0\uc774 \ud655\uc778\ub418\uba74 \uac00\ub2a5\ud55c \ube68\ub9ac \ud22c\uc57d\uc744 \uc911\uc9c0\ud55c\ub2e4. \uc0ac\ub78c\uc758 \uacbd\uc6b0, \ud0dc\uc544\uc758 \uc2e0\uc7a5 \uad00\ub958\ub294 \ub808\ub2cc-\uc548\uc9c0\uc624\ud150\uc2e0\uacc4\uc758 \ubc1c\uc721\uc5d0 \ub530\ub77c \uc784\uc2e0 2\uae30\uc5d0 \uc2dc\uc791\ub418\ubbc0\ub85c, \uc784\uc2e0 2, 3\uae30\uc5d0 \uc774 \uc57d\uc744 \ud22c\uc5ec \uc2dc \ud0dc\uc544\uc5d0\uac8c \ubbf8\uce58\ub294 \uc704\ud5d8\uc740 \uc99d\uac00\ud55c\ub2e4. \uc784\uc2e0 2 ~ 3\uae30 \uc0ac\uc774\uc5d0 \ub808\ub2cc-\uc548\uc9c0\uc624\ud150\uc2e0-\uc54c\ub3c4\uc2a4\ud14c\ub860\uacc4\uc5d0 \uc9c1\uc811 \uc791\uc6a9\ud558\ub294 \uc57d\ubb3c\uad70\uc758 \ud22c\uc5ec\ub294 \ud0dc\uc544 \ubc0f \uc2e0\uc0dd\uc544\uc758 \uc800\ud608\uc555, \uace0\uce7c\ub968\ud608\uc99d, \uc2e0\uc0dd\uc544 \ub450\uac1c\uace8 \ud615\uc131\uc800\ud558\uc99d, \uc694\uac10\uc18c \uadf8\ub9ac\uace0\/\ud639\uc740 \ubb34\ub1e8\uc99d, \uac00\uc5ed\uc801 \ub610\ub294 \ube44\uac00\uc5ed\uc801\uc778 \uc2e0\ubd80\uc804, \uc790\uad81 \ub0b4 \uc131\uc7a5 \uc9c0\uccb4 \ubc0f \uc0ac\ub9dd\uc744 \ud3ec\ud568\ud558\uc5ec \ud0dc\uc544 \ubc0f \uc2e0\uc0dd\uc544 \uc190\uc0c1\uacfc \uc5f0\uad00\uc131\uc774 \uc788\uc5c8\ub2e4. \ud0dc\uc544 \uc2e0\uae30\ub2a5 \uac10\uc18c \ub54c\ubb38\uc778 \uac83\uc73c\ub85c \ucd94\uce21\ub41c \uc591\uc218\uacfc\uc18c\uc99d\uc774 \ubcf4\uace0 \ub418\uc5c8\uace0, \uc591\uc218\uacfc\uc18c\uc99d\uc740 \ud0dc\uc544 \uc0ac\uc9c0\uad6c\ucd95, \ub450\uac1c\uc548\uba74 \uae30\ud615 \ubc0f \ud3d0\ud615\uc131 \uc800\ud558\uc99d\uacfc \uc5f0\uad00\uc131\uc774 \uc788\uc5c8\ub2e4. \ub610\ud55c \uc774 \uc57d\uc5d0 \uc758\ud55c \uac83\uc778\uc9c0 \uba85\ud655\ud558\uc9c4 \uc54a\uc9c0\ub9cc \ubbf8\uc219, \uc790\uad81 \ub0b4 \ubc1c\uc721 \uc9c0\uc5f0, \ub3d9\ub9e5\uad00 \uc5f4\ub9bc\uc99d\uc774 \ub098\ud0c0\ub0ac\ub2e4\ub294 \ubcf4\uace0\uac00 \uc788\ub2e4. \uc5ed\ud559\uc790\ub8cc\uc5d0\uc11c \uc784\uc2e0 1\uae30\uc5d0 ACE \uc800\ud574\uc81c\uc5d0 \ub178\ucd9c\ub41c \uacbd\uc6b0 \ucd5c\uae30\ud615\uc131 \uc704\ud5d8\uc5d0 \ub300\ud55c \uc99d\uac70\ub294 \uba85\ud655\ud558\uc9c0 \uc54a\uc73c\ub098, \uc5b4\ub290 \uc815\ub3c4\uc758 \uc704\ud5d8 \uc99d\uac00\ub97c \ubc30\uc81c\ud560 \uc218 \uc5c6\ub2e4. \uc548\uc9c0\uc624\ud150\uc2e0\uc218\uc6a9\uccb4\ucc28\ub2e8\uc81c\uc758 \uc704\ud5d8\uc131\uc5d0 \ub300\ud55c \ud1b5\uc81c\ub41c \uc5ed\ud559\uc790\ub8cc\ub294 \uc5c6\uc73c\ub098, \uc774 \uacc4\uc5f4 \uc57d\ubb3c\ub4e4\uc5d0\ub3c4 \uc720\uc0ac\ud55c \uc815\ub3c4\uc758 \uc704\ud5d8\uc131\uc774 \ub098\ud0c0\ub0a0 \uc218 \uc788\ub2e4. \uc784\uc2e0 \uae30\uac04 \ub3d9\uc548 \uc784\ubd80\uc758 \uace0\ud608\uc555\uc744 \uc801\uc808\ud788 \uad00\ub9ac\ud558\ub294 \uac83\uc740 \uc784\ubd80\uc640 \ud0dc\uc544 \ubaa8\ub450\uc5d0\uac8c \ucd5c\uc801\ud654\ub41c \uacb0\uacfc\ub97c \uc8fc\ub294 \ub370 \uc911\uc694\ud558\ub2e4. \ub4dc\ubb3c\uc9c0\ub9cc \ub808\ub2cc\uc548\uc9c0\uc624\ud150\uc2e0 \uacc4\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uc57d\ubb3c\uc5d0 \ub300\ud55c \uc801\uc808\ud55c \ub300\uccb4\uc57d\ubb3c\uc774 \uc5c6\ub294 \uacbd\uc6b0(\ub300\uccb4\ub85c \ucc9c \uba85\uc758 \uc784\ubd80 \uc911 \ud55c \uba85 \uaf34 \uc774\ud558\ub85c \ubc1c\ud604) \uc784\ubd80\uc5d0\uac8c \ud0dc\uc544\uc5d0 \ub300\ud55c \uc7a0\uc7ac\uc801\uc778 \uc704\ud5d8\uc744 \uc778\uc9c0\uc2dc\ucf1c\uc57c \ud558\uba70, \uc591\ub9c9 \ub0b4 \ud658\uacbd\uc744 \ud655\uc778\ud558\uae30 \uc704\ud574 \uc77c\ub828\uc758 \ucd08\uc74c\ud30c \uac80\uc0ac\ub97c \uc2e4\uc2dc\ud558\uc5ec\uc57c \ud55c\ub2e4. \uc591\uc218\uacfc\uc18c\uc99d\uc774 \uad00\ucc30\ub420 \uacbd\uc6b0, \uc784\ubd80\uc758 \uc0dd\uba85\uc744 \uad6c\ud558\uae30 \uc704\ud55c \uacbd\uc6b0\ub97c \uc81c\uc678\ud558\uace0\ub294 \uc774 \uc57d\uc758 \ud22c\uc5ec\ub97c \uc911\ub2e8\ud574\uc57c \ud55c\ub2e4. \uc784\uc2e0 \uc8fc\uc218\uc5d0 \ub530\ub77c\uc11c \uc218\ucd95\uc2a4\ud2b8\ub808\uc2a4\uac80\uc0ac(Contraction Stress Testing), \ube44\ubd80\ud558\uac80\uc0ac(Non-stress Test) \ud639\uc740 \uc0dd\ubb3c\uc774\ud559\uc801 \ud504\ub85c\ud30c\uc77c(Biophysical Profiling) \ub4f1\uc758 \uac80\uc0ac\uac00 \uc815\uc0c1\uc77c \uc218 \uc788\ub2e4. \ud558\uc9c0\ub9cc \ud0dc\uc544\uc5d0\uac8c \uc774\ubbf8 \ube44\uac00\uc5ed\uc801 \uc7a5\uc560\uac00 \ubc1c\uc0dd\ud55c \uc774\ud6c4\uc5d0\ub3c4 \uc591\uc218\uacfc\uc18c\uc99d\uc774 \ub098\ud0c0\ub098\uc9c0 \uc54a\uc744 \uc218 \uc788\ub2e4. \uc790\uad81 \ub0b4\uc5d0\uc11c \uc548\uc9c0\uc624\ud150\uc2e0II \uc218\uc6a9\uccb4 \ucc28\ub2e8\uc81c\uc5d0 \ub178\ucd9c\ub41c \uacbd\ud5d8\uc774 \uc788\ub294 \uc2e0\uc0dd\uc544, \uc601\u00b7\uc720\uc544\uc758 \uacbd\uc6b0 \uc800\ud608\uc555, \uc18c\ubcc0\uac10\uc18c\uc99d \ubc0f \uace0\uce7c\ub968\ud608\uc99d\uc774 \uc788\ub294\uc9c0 \uba74\ubc00\ud788 \uad00\ucc30\ud574\uc57c \ud55c\ub2e4. \ub9cc\uc57d \uc18c\ubcc0\uac10\uc18c\uc99d\uc774\ub098 \uc800\ud608\uc555\uc774 \ub098\ud0c0\ub09c\ub2e4\uba74, \ud608\uc555 \ubc0f \uc2e0\uc7a5\uad00\ub958\uc5d0 \ub300\ud55c \uc9c1\uc811\uc801\uc778 \uad00\ub9ac\ub97c \ud574\uc57c \ud55c\ub2e4. \uc800\ud608\uc555\uc744 \ud68c\ubcf5\uc2dc\ud0a4\uace0, \uc800\ud558\ub41c \uc2e0\uae30\ub2a5\uc744 \ub300\uc2e0\ud558\uae30 \uc704\ud574 \uad50\ud658\uc218\ud608\uc774\ub098 \ud22c\uc11d\uc744 \ud560 \uc218\ub3c4 \uc788\ub2e4. \ub85c\uc0ac\ub974\ud0c4\uce7c\ub968\uc740 \ub7ab\ud2b8\uc758 \ud0dc\uc790 \ubc0f \uc0c8\ub07c\uc5d0\uc11c \uccb4\uc911 \uac10\uc18c, \uc721\uccb4\/\ud589\ub3d9 \ubc1c\ub2ec \uc9c0\uc5f0, \uc0ac\ub9dd\ub960 \ubc0f \uc2e0\uc7a5\ub3c5\uc131\uc744 \ud3ec\ud568\ud55c \uc774\uc0c1\ubc18\uc751\uc744 \uc720\ubc1c\uc2dc\ucf30\ub2e4. \uc2e0\uc0dd\uc790\uc5d0\uc11c\uc758 \uccb4\uc911\uc99d\uac00\uc728 \uac10\uc18c(10 mg\/kg\/day\uc758 \ub0ae\uc740 \ud22c\uc5ec\uc6a9\ub7c9\uc5d0\uc11c \uc601\ud5a5 \ubc1b\uc740 \uac83\uc784)\ub97c \uc81c\uc678\ud558\uace0\ub294, \uc774\ub7ec\ud55c \uc774\uc0c1\ubc18\uc751\ub4e4\uc774 \ubc1c\ud604\ub41c \uac83\uc740 25 mg\/kg\/day\uc744 \ucd08\uacfc\ud55c \ud22c\uc5ec\uc6a9\ub7c9\uc5d0\uc11c\uc600\ub2e4(mg\/m<sup>2<\/sup>\uc5d0 \uadfc\uac70\ud558\uc5ec \uc0ac\ub78c\uc758 \ucd5c\ub300 \uad8c\uc7a5\uc6a9\ub7c9\uc778 100 mg\uc758 \uc57d 3\ubc30\uc5d0 \ud574\ub2f9\ub428). \uc774\ub7ec\ud55c \uc774\uc0c1\ubc18\uc751\ub4e4\uc740 \uc784\uc2e0\ub9d0\uae30 \ubc0f \uc218\uc720 \uc911 \uc57d\ubb3c\uc758 \ub178\ucd9c\uc5d0 \uae30\uc778\ud55c \uac83\uc774\ub2e4. 2) \uc218\uc720\ubd80. \uc0ac\ub78c\uc5d0\uc11c \uc554\ub85c\ub514\ud540 \ubc0f\/\ub610\ub294 \ub85c\uc0ac\ub974\ud0c4\uc758 \uc720\uc999 \ubd84\ube44 \uc5ec\ubd80\ub294 \uc54c\ub824\uc9c0\uc9c0 \uc54a\uc558\uc73c\ub098, \ub3d9\ubb3c\uc2dc\ud5d8\uc5d0\uc11c \uc554\ub85c\ub514\ud540 \ubc0f \ub85c\uc0ac\ub974\ud0c4\uc758 \ud65c\uc131\ub300\uc0ac\ubb3c\uc758 \ubaa8\uc720 \uc911\uc73c\ub85c\uc758 \uc774\ud589\uc774 \ubcf4\uace0\ub418\uc5c8\uc73c\ubbc0\ub85c \uc218\uc720 \uc911\uc5d0\ub294 \ud22c\uc5ec\ud558\uc9c0 \uc54a\ub294\ub2e4. <strong>[\uc18c\uc544\uc5d0 \ub300\ud55c \ud22c\uc5ec]<\/strong> \ub9cc 18\uc138 \uc774\ud558\uc758 \uc18c\uc544\ud658\uc790\uc5d0 \ub300\ud55c \uc548\uc804\uc131\u00b7\uc720\ud6a8\uc131\uc774 \ud655\ub9bd\ub418\uc5b4 \uc788\uc9c0 \uc54a\uc73c\ubbc0\ub85c, \uc774 \uc57d\uc758 \ud22c\uc5ec\uac00 \uad8c\uc7a5\ub418\uc9c0 \uc54a\ub294\ub2e4. <strong>[\uace0\ub839\uc790\uc5d0 \ub300\ud55c \ud22c\uc5ec] <\/strong>75\uc138 \uc774\uc0c1\uc758 \uace0\ub839\uc790\uc5d0 \ub300\ud574 \ub85c\uc0ac\ub974\ud0c4\uc758 \ucd08\ud68c\uc6a9\ub7c9\uc73c\ub85c 1\uc77c 1\ud68c 25 mg\uc774 \uad8c\uc7a5\ub418\ub098, \uc774 \uc57d\uc73c\ub85c\ub294 \ub85c\uc0ac\ub974\ud0c4 25 mg \ud22c\uc5ec\uac00 \uac00\ub2a5\ud558\uc9c0 \uc54a\uc73c\ubbc0\ub85c, \ucd08\uae30 \uce58\ub8cc \uc2dc \uc774 \uc57d(\ubcf5\ud569\uc81c)\uc744 \ud22c\uc5ec\ud558\ub294 \uac83\uc740 \uad8c\uc7a5\ub418\uc9c0 \uc54a\ub294\ub2e4. \uac1c\uc815\ub144\uc6d4\uc77c : 2025\ub144 11\uc6d4 03\uc77c<\/p>\n\n\n\n<p class=\"has-text-align-left\"><strong>\u203b \ucc98\ubc29\ud558\uc2dc\uae30 \uc804\uc5d0 \uc81c\ud488\uc124\uba85\uc11c\ub97c \ucc38\uace0\ud558\uc2dc\uae30 \ubc14\ub78d\ub2c8\ub2e4<\/strong><\/p>\n\n\n\n<p class=\"has-text-align-right\">KR-LSN-110402 11\/2027<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Selected Safety Information \ucf54\uc790\u00ae\uc815 (\ub85c\uc0ac\ub974\ud0c4\uce7c\ub968) 50, 100 mg [\ud6a8\ub2a5\u00b7\ud6a8\uacfc] 1. \uace0\ud608\uc555 2. \uc88c\uc2ec\uc2e4 \ube44\ub300\uac00 \uc788\ub294 \uace0\ud608\uc555 \ud658\uc790\uc5d0\uc11c\uc758 \ub1cc\uc878\uc911 \ubc1c\uc0dd \uc704\ud5d8\uc758 \uac10\uc18c&nbsp; 3. \uace0\ud608\uc555 \uce58\ub8cc\uc694\ubc95\uc73c\ub85c\uc11c, \uace0\ud608\uc555\uc744 \uac00\uc9c4 \uc81c2\ud615 \ub2f9\ub1e8\ubcd1 \ud658\uc790\uc758 \uc2e0\uc7a5\ubcd1 [\uc6a9\ubc95\u00b7\uc6a9\ub7c9] 1. \uace0\ud608\uc555 \uc131\uc778: \ucd08\ud68c\ub7c9\uacfc \uc720\uc9c0\ub7c9\uc740 \ub85c\uc0ac\ub974\ud0c4\uce7c\ub968\uc73c\ub85c\uc11c 1\uc77c 1\ud68c 50 mg \uacbd\uad6c\ud22c\uc5ec \ud558\ub294 \uac83\uc774 \uad8c\uc7a5\ub41c\ub2e4. \uce58\ub8cc \uc2dc\uc791 \ud6c4 3\u223c6 \uc8fc \ud6c4\uc5d0 \ucd5c\ub300 \ud608\uc555 \uac15\ud558 \ud6a8\uacfc\uac00 [&hellip;]<\/p>\n","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-6611","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.11 (Yoast SEO v26.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\ucf54\uc790\ud328\ubc00\ub9ac \uc8fc\uc694 \uc548\uc804\uc131 \uc815\ubcf4 - Organon Pro - Korea<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\ucf54\uc790\ud328\ubc00\ub9ac \uc8fc\uc694 \uc548\uc804\uc131 \uc815\ubcf4\" \/>\n<meta property=\"og:description\" content=\"Selected Safety Information \ucf54\uc790\u00ae\uc815 (\ub85c\uc0ac\ub974\ud0c4\uce7c\ub968) 50, 100 mg [\ud6a8\ub2a5\u00b7\ud6a8\uacfc] 1. \uace0\ud608\uc555 2. \uc88c\uc2ec\uc2e4 \ube44\ub300\uac00 \uc788\ub294 \uace0\ud608\uc555 \ud658\uc790\uc5d0\uc11c\uc758 \ub1cc\uc878\uc911 \ubc1c\uc0dd \uc704\ud5d8\uc758 \uac10\uc18c&nbsp; 3. \uace0\ud608\uc555 \uce58\ub8cc\uc694\ubc95\uc73c\ub85c\uc11c, \uace0\ud608\uc555\uc744 \uac00\uc9c4 \uc81c2\ud615 \ub2f9\ub1e8\ubcd1 \ud658\uc790\uc758 \uc2e0\uc7a5\ubcd1 [\uc6a9\ubc95\u00b7\uc6a9\ub7c9] 1. \uace0\ud608\uc555 \uc131\uc778: \ucd08\ud68c\ub7c9\uacfc \uc720\uc9c0\ub7c9\uc740 \ub85c\uc0ac\ub974\ud0c4\uce7c\ub968\uc73c\ub85c\uc11c 1\uc77c 1\ud68c 50 mg \uacbd\uad6c\ud22c\uc5ec \ud558\ub294 \uac83\uc774 \uad8c\uc7a5\ub41c\ub2e4. \uce58\ub8cc \uc2dc\uc791 \ud6c4 3\u223c6 \uc8fc \ud6c4\uc5d0 \ucd5c\ub300 \ud608\uc555 \uac15\ud558 \ud6a8\uacfc\uac00 [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/organonpro.com\/ko-kr\/cozaar_ssi\/\" \/>\n<meta property=\"og:site_name\" content=\"Organon Pro - Korea\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-23T06:05:24+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/organonpro.com\/ko-kr\/wp-content\/uploads\/sites\/5\/2022\/12\/organon-pro-og-img.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"630\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"20 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/organonpro.com\/ko-kr\/cozaar_ssi\/\",\"url\":\"https:\/\/organonpro.com\/ko-kr\/cozaar_ssi\/\",\"name\":\"\ucf54\uc790\ud328\ubc00\ub9ac \uc8fc\uc694 \uc548\uc804\uc131 \uc815\ubcf4 - Organon Pro - 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