{"id":130,"date":"2022-07-22T14:14:25","date_gmt":"2022-07-22T14:14:25","guid":{"rendered":"https:\/\/organonpro.com\/ja-jp\/?post_type=product&p=130"},"modified":"2024-08-13T12:19:03","modified_gmt":"2024-08-13T12:19:03","slug":"effect","status":"publish","type":"product","link":"https:\/\/organonpro.com\/ja-jp\/product\/singulair\/pick-up\/effect\/","title":{"rendered":"\u5598\u606f\u3068\u9f3b\u708e\u306b\u5bfe\u3059\u308b\u52b9\u679c"},"content":{"rendered":"\n

\u300c\u7981\u5fcc\u3092\u542b\u3080\u4f7f\u7528\u4e0a\u306e\u6ce8\u610f\u300d\u7b49\u306f\u88fd\u54c1\u6dfb\u4ed8\u6587\u66f8\u3092\u3054\u53c2\u7167\u304f\u3060\u3055\u3044\u3002<\/strong><\/p>\n\n\n\n

\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e
\u5b63\u7bc0\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306b\u5bfe\u3059\u308b\u6709\u7528\u6027<\/h3>\n\n\n\n

\u25a0\u5b89\u5168\u6027\u60c5\u5831\uff1a\u526f\u4f5c\u7528\u767a\u73fe\u72b6\u6cc1\u306e\u4e00\u89a7\uff08\u4f7f\u7528\u6210\u7e3e\u8abf\u67fb\uff09<\/h4>\n\n\n\n
\"\"<\/figure>\n\n\n\n

\u526f\u4f5c\u7528\u540d\u306f\u65e5\u672c\u8a9e\u7248MedDRA\/J ver.14.1 \u3092\u4f7f\u7528\u3057\u305f\u3002
\u6ce8\uff1a\u526f\u4f5c\u7528\u306e\u5668\u5b98\u5225\u5927\u5206\u985e\u306e\u96c6\u8a08\u306f\u767a\u73fe\u4f8b\u6570\u3001\u526f\u4f5c\u7528\u306e\u96c6\u8a08\u306f\u767a\u73fe\u4ef6\u6570\u3092\u793a\u3057\u305f\u3002
<\/p>\n\n\n\n

\u25a0\u6709\u52b9\u6027\u60c5\u5831 \uff1a\u5404\u9f3b\u75c7\u72b6\u306e\u672c\u5264\u4f7f\u7528\u306b\u3088\u308b\u5168\u822c\u7684\u5370\u8c61\uff08\u4f7f\u7528\u6210\u7e3e\u8abf\u67fb\uff09<\/h4>\n\n\n\n
\"\"<\/figure>\n\n\n\n
\n
\n

1\uff09\u3088\u308a\u6539\u5909<\/p>\n<\/div>\n\n\n\n

<\/div>\n\n\n\n
<\/div>\n<\/div>\n\n\n\n

\u3008\u5bfe\u8c61\u3009
\u5b63\u7bc0\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u60a3\u8005\uff08\u5b89\u5168\u6027\u96c6\u8a08\u5bfe\u8c61\u75c7\u4f8b728 \u4f8b\u3001\u6709\u52b9\u6027\u96c6\u8a08\u5bfe\u8c61\u75c7\u4f8b692 \u4f8b\uff09<\/p>\n\n\n\n

\u3008\u65b9\u6cd5\u3009
\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306b\u5bfe\u3057\u3001\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u88fd\u5264\u3092\u627f\u8a8d\u3055\u308c\u305f\u7528\u6cd5\u30fb\u7528\u91cf\uff08\u901a\u5e38\u3001\u6210\u4eba\u306b\u306f\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u3068\u3057\u30665\uff5e10mg\u30921\u65e51\u56de\u5c31\u5bdd\u524d\u306b\u7d4c\u53e3\u6295\u4e0e\uff09\u3067\u65b0\u898f\u306b\u6295\u4e0e\u958b\u59cb\u3057\u305f\u3001\u5b63\u7bc0\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u3001\u8033\u9f3b\u79d1\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u79d1\u3001\u5185\u79d1\u3092\u6709\u3059\u308b\u533b\u7642\u6a5f\u95a2\u3067\u3001\u30d7\u30ed\u30b9\u30da\u30af\u30c6\u30a3\u30d6\u306a\u9023\u7d9a\u8abf\u67fb\u65b9\u5f0f\u306b\u3088\u308a\u8abf\u67fb\u3092\u5b9f\u65bd\u3057\u305f\u3002\u89b3\u5bdf\u671f\u9593\u306f\u6295\u4e0e\u958b\u59cb\u65e5\u304b\u3089\u6700\u7d42\u89b3\u5bdf\u65e5\u307e\u3067\u3068\u5b9a\u7fa9\u3057\u3001\u539f\u5247\u3068\u3057\u30662\u9031\u9593\u4ee5\u4e0a\u3068\u3057\u305f\u3002<\/p>\n\n\n\n

\u3008\u8a55\u4fa1\u9805\u76ee\u3009
\u65e5\u5e38\u8a3a\u7642\u306b\u304a\u3051\u308b\u4f7f\u7528\u5b9f\u614b\u4e0b\u306b\u304a\u3044\u3066\u5b63\u7bc0\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306b\u4f7f\u7528\u3055\u308c\u305f\u969b\u306e\u5b89\u5168\u6027\uff08\u6709\u5bb3\u4e8b\u8c61\uff09\u304a\u3088\u3073\u6709\u52b9\u6027\uff08\u5168\u822c\u6539\u5584\u5ea6\u3001\u5168\u822c\u7684\u5370\u8c61\uff09<\/p>\n\n\n\n

\u3008\u89e3\u6790\u8a08\u753b\u3009
\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u88fd\u5264\u306e\u5b89\u5168\u6027\u304a\u3088\u3073\u6709\u52b9\u6027\u306b\u95a2\u3059\u308b\u60c5\u5831\u306e\u96c6\u8a08\u3001\u89e3\u6790\u3092\u884c\u3063\u305f\u3002\u526f\u4f5c\u7528\u767a\u73fe\u72b6\u6cc1\u304a\u3088\u3073\u6709\u52b9\u7387\u306e\u60a3\u8005\u80cc\u666f\u5225\u306e\u5c64\u5225\u89e3\u6790\u3067\u306f\u3001\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u9806\u5e8f\u304c\u3042\u308b\u5e74\u9f62\u91cd\u75c7\u5ea6\u7f79\u75c5\u671f\u9593\u4f7f\u7528\u671f\u9593\u3001\u7dcf\u6295\u4e0e\u91cf\u306b\u3064\u3044\u3066\u306f\u3001Wilcoxon\u306e\u9806\u4f4d\u548c\u691c\u5b9a\u3092\u5b9f\u65bd\u3057\u305f\u3002\u305d\u308c\u4ee5\u5916\u306e\u9805\u76ee\u3067\u3001\u81ea\u7531\u5ea6(DF) = 1\u306e\u3068\u304d\u306fFisher\u306e\u76f4\u63a5\u78ba\u7387\u691c\u5b9a\u3001DF\u22672\u306e\u3068\u304d\u306f\u03c72<\/sup>\u691c\u5b9a\u3092\u5b9f\u65bd\u3057\u305f\u3002\u6709\u610f\u6c34\u6e96\u306f\u4e21\u50745\uff05\u3068\u3057\u305f\u3002<\/p>\n\n\n\n

1\uff09\u4e39\u4e0b \u967d\u5b50 \u4ed6. \u65b0\u85ac\u3068\u81e8\u7240 2015; 64: 1334-1356.\u3088\u308a\u6539\u5909
\u3010\u5229\u76ca\u76f8\u53cd\u3011\u672c\u8abf\u67fb\u306fMSD\u793e\uff08\u4f1a\u793e\u5206\u5272\u306b\u3088\u308a\u30a6\u30a3\u30e1\u30f3\u30ba\u30d8\u30eb\u30b9\u53ca\u3073\u30ec\u30ac\u30b7\u30fc\u30d6\u30e9\u30f3\u30c9\u95a2\u9023\u306e\u7279\u5b9a\u306e\u88fd\u54c1\u306e\u4e8b\u696d\u306b\u95a2\u3059\u308b\u6a29\u5229\u7fa9\u52d9\u3092\u30aa\u30eb\u30ac\u30ce\u30f3\u682a\u5f0f\u4f1a\u793e\u306b\u627f\u7d99\u3055\u305b\u305f\u3002\u4ee5\u4e0b\u540c\u69d8\uff09\u306b\u3088\u308a\u5b9f\u65bd\u3055\u308c\u305f\u3002\u8457\u8005\u306e\u3046\u3061\u4e39\u4e0b\u3001\u9577\u5d0e\u3001\u5c0f\u6cc9\u3001\u539f\u306fMSD\u793e\u54e1\u3002<\/p>\n\n\n\n

\u901a\u5e74\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306b\u5bfe\u3059\u308b\u6709\u7528\u6027<\/h3>\n\n\n\n

\u25a0\u5b89\u5168\u6027\u60c5\u5831\uff1a\u526f\u4f5c\u7528\u767a\u73fe\u72b6\u6cc1\u306e\u4e00\u89a7\uff08\u7279\u5b9a\u4f7f\u7528\u6210\u7e3e\u8abf\u67fb\uff09<\/h4>\n\n\n\n
\"\"<\/figure>\n\n\n\n

\uff0a\uff1a\u4f7f\u7528\u4e0a\u306e\u6ce8\u610f\u304b\u3089\u4e88\u6e2c\u3067\u304d\u306a\u3044\u526f\u4f5c\u7528
\u526f\u4f5c\u7528\u540d\u306f\u65e5\u672c\u8a9e\u7248MedDRA\/J ver.14.1 \u3092\u4f7f\u7528\u3057\u305f\u3002
\u6ce8\uff1a\u526f\u4f5c\u7528\u306e\u5668\u5b98\u5225\u5927\u5206\u985e\u306e\u96c6\u8a08\u306f\u767a\u73fe\u4f8b\u6570\u3001\u526f\u4f5c\u7528\u306e\u96c6\u8a08\u306f\u767a\u73fe\u4ef6\u6570\u3092\u793a\u3057\u305f\u3002<\/p>\n\n\n\n

\u25a0\u6709\u52b9\u6027\u60c5\u5831 \uff1a\u5404\u9f3b\u75c7\u72b6\u306e\u672c\u5264\u4f7f\u7528\u306b\u3088\u308b\u5168\u822c\u7684\u5370\u8c61\uff08\u7279\u5b9a\u4f7f\u7528\u6210\u7e3e\u8abf\u67fb\uff09<\/h4>\n\n\n\n
\"\"<\/figure>\n\n\n\n
\n
\n

1\uff09\u3088\u308a\u6539\u5909<\/p>\n<\/div>\n\n\n\n

<\/div>\n\n\n\n
<\/div>\n<\/div>\n\n\n\n

\u3008\u5bfe\u8c61\u3009
\u901a\u5e74\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u60a3\u8005\uff08\u5b89\u5168\u6027\u96c6\u8a08\u5bfe\u8c61\u75c7\u4f8b637\u4f8b\u3001\u6709\u52b9\u6027\u96c6\u8a08\u5bfe\u8c61\u75c7\u4f8b583\u4f8b\uff09<\/p>\n\n\n\n

\u3008\u65b9\u6cd5\u3009
\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306b\u5bfe\u3057\u3001\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u88fd\u5264\u3092\u627f\u8a8d\u3055\u308c\u305f\u7528\u6cd5\u30fb\u7528\u91cf\uff08\u901a\u5e38\u3001\u6210\u4eba\u306b\u306f\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u3068\u3057\u30665\uff5e10mg\u30921\u65e51\u56de\u5c31\u5bdd\u524d\u306b\u7d4c\u53e3\u6295\u4e0e\uff09 \u3067\u65b0\u898f\u306b\u6295\u4e0e\u958b\u59cb\u3057\u305f\u3001\u8033\u9f3b\u79d1\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u79d1\u3001\u5185\u79d1\u3092\u6709\u3059\u308b\u533b\u7642\u6a5f\u95a2\u3067\u3001\u30d7\u30ed\u30b9\u30da\u30af\u30c6\u30a3\u30d6\u306a\u9023\u7d9a\u8abf\u67fb\u65b9\u5f0f\u306b\u3088\u308a\u8abf\u67fb\u3092\u5b9f\u65bd\u3057\u305f\u3002\u89b3\u5bdf\u671f\u9593\u306f\u6295\u4e0e\u958b\u59cb\u65e5\u304b\u3089\u6700\u7d42\u89b3\u5bdf\u65e5\u307e\u3067\u3068\u5b9a\u7fa9\u3057\u3001\u539f\u5247\u3068\u3057\u306612\u9031\u9593\u4ee5\u4e0a\u3068\u3057\u305f\u3002<\/p>\n\n\n\n

\u3008\u8a55\u4fa1\u9805\u76ee\u3009
\u65e5\u5e38\u8a3a\u7642\u306b\u304a\u3051\u308b\u4f7f\u7528\u5b9f\u614b\u4e0b\u306b\u304a\u3044\u3066\u901a\u5e74\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306b\u9577\u671f\u4f7f\u7528\u3055\u308c\u305f\u969b\u306e\u5b89\u5168\u6027\uff08\u6709\u5bb3\u4e8b\u8c61\uff09\u304a\u3088\u3073\u6709\u52b9\u6027\uff08\u5168\u822c\u6539\u5584\u5ea6\u3001\u5168\u822c\u7684\u5370\u8c61\uff09<\/p>\n\n\n\n

\u3008\u89e3\u6790\u8a08\u753b\u3009
\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u88fd\u5264\u306e\u5b89\u5168\u6027\u304a\u3088\u3073\u6709\u52b9\u6027\u306b\u95a2\u3059\u308b\u60c5\u5831\u306e\u96c6\u8a08\u3001\u89e3\u6790\u3092\u884c\u3063\u305f\u3002\u526f\u4f5c\u7528\u767a\u73fe\u72b6\u6cc1\u304a\u3088\u3073\u6709\u52b9\u7387\u306e\u60a3\u8005\u80cc\u666f\u5225\u306e\u5c64\u5225\u89e3\u6790\u3067\u306f\u3001\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u9806\u5e8f\u304c\u3042\u308b\u5e74\u9f62\u91cd\u75c7\u5ea6\u7f79\u75c5\u671f\u9593\u4f7f\u7528\u671f\u9593\u3001\u7dcf\u6295\u4e0e\u91cf\u306b\u3064\u3044\u3066\u306f\u3001Wilcoxon\u306e\u9806\u4f4d\u548c\u691c\u5b9a\u3092\u5b9f\u65bd\u3057\u305f\u3002\u305d\u308c\u4ee5\u5916\u306e\u9805\u76ee\u3067\u3001\u81ea\u7531\u5ea6(DF) = 1\u306e\u3068\u304d\u306fFisher\u306e\u76f4\u63a5\u78ba\u7387\u691c\u5b9a\u3001 DF\u22672\u306e\u3068\u304d\u306f\u03c72<\/sup>\u691c\u5b9a\u3092\u5b9f\u65bd\u3057\u305f\u3002\u6709\u610f\u6c34\u6e96\u306f\u4e21\u50745\uff05\u3068\u3057\u305f\u3002<\/p>\n\n\n\n

1\uff09\u4e39\u4e0b \u967d\u5b50 \u4ed6. \u65b0\u85ac\u3068\u81e8\u7240 2015; 64: 1334-1356
\u3010\u5229\u76ca\u76f8\u53cd\u3011\u672c\u8abf\u67fb\u306fMSD\u793e\uff08\u4f1a\u793e\u5206\u5272\u306b\u3088\u308a\u30a6\u30a3\u30e1\u30f3\u30ba\u30d8\u30eb\u30b9\u53ca\u3073\u30ec\u30ac\u30b7\u30fc\u30d6\u30e9\u30f3\u30c9\u95a2\u9023\u306e\u7279\u5b9a\u306e\u88fd\u54c1\u306e\u4e8b\u696d\u306b\u95a2\u3059\u308b\u6a29\u5229\u7fa9\u52d9\u3092\u30aa\u30eb\u30ac\u30ce\u30f3\u682a\u5f0f\u4f1a\u793e\u306b\u627f\u7d99\u3055\u305b\u305f\u3002\u4ee5\u4e0b\u540c\u69d8\uff09\u306b\u3088\u308a\u5b9f\u65bd\u3055\u308c\u305f\u3002\u8457\u8005\u306e\u3046\u3061\u4e39\u4e0b\u3001\u9577\u5d0e\u3001\u5c0f\u6cc9\u3001\u539f\u306fMSD\u793e\u54e1\u3002<\/p>\n\n\n\n

\u3008\u5bfe\u8c61\u3009
\u901a\u5e74\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u60a3\u8005\uff08\u5b89\u5168\u6027\u96c6\u8a08\u5bfe\u8c61\u75c7\u4f8b637\u4f8b\u3001\u6709\u52b9\u6027\u96c6\u8a08\u5bfe\u8c61\u75c7\u4f8b583\u4f8b\uff09<\/p>\n\n\n\n

\u3008\u65b9\u6cd5\u3009
\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306b\u5bfe\u3057\u3001\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u88fd\u5264\u3092\u627f\u8a8d\u3055\u308c\u305f\u7528\u6cd5\u30fb\u7528\u91cf\uff08\u901a\u5e38\u3001\u6210\u4eba\u306b\u306f\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u3068\u3057\u30665\uff5e10mg\u30921\u65e51\u56de\u5c31\u5bdd\u524d\u306b\u7d4c\u53e3\u6295\u4e0e\uff09 \u3067\u65b0\u898f\u306b\u6295\u4e0e\u958b\u59cb\u3057\u305f\u3001\u8033\u9f3b\u79d1\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u79d1\u3001\u5185\u79d1\u3092\u6709\u3059\u308b\u533b\u7642\u6a5f\u95a2\u3067\u3001\u30d7\u30ed\u30b9\u30da\u30af\u30c6\u30a3\u30d6\u306a\u9023\u7d9a\u8abf\u67fb\u65b9\u5f0f\u306b\u3088\u308a\u8abf\u67fb\u3092\u5b9f\u65bd\u3057\u305f\u3002\u89b3\u5bdf\u671f\u9593\u306f\u6295\u4e0e\u958b\u59cb\u65e5\u304b\u3089\u6700\u7d42\u89b3\u5bdf\u65e5\u307e\u3067\u3068\u5b9a\u7fa9\u3057\u3001\u539f\u5247\u3068\u3057\u306612\u9031\u9593\u4ee5\u4e0a\u3068\u3057\u305f\u3002<\/p>\n\n\n\n

\u3008\u8a55\u4fa1\u9805\u76ee\u3009
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1\uff09\u4e39\u4e0b \u967d\u5b50 \u4ed6. \u65b0\u85ac\u3068\u81e8\u7240 2015; 64: 1334-1356
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\u6c17\u7ba1\u652f\u5598\u606f
\u30b7\u30f3\u30b0\u30ec\u30a2\u00ae<\/sup>\u8ffd\u52a0\u6295\u4e0e\u306fACT\u30b9\u30b3\u30a2\u203b<\/sup>\u3092\u4e0a\u6607\u3055\u305b\u307e\u3057\u305f\uff08\u6d77\u5916\u30c7\u30fc\u30bf\uff09<\/h3>\n\n\n\n

\u203bACT\uff1aAsthma Control Test \u30025\u3064\u306e\u8cea\u554f\u3067\u69cb\u6210\u3055\u308c\u3001\u305d\u308c\u305e\u308c\u30921\uff5e5\u306e\u30b9\u30b1\u30fc\u30eb\u3067\u8a55\u4fa1\u3057\u3001\u5408\u8a08\u3057\u305f\u30b9\u30b3\u30a2\u3067\u5598\u606f\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u5ea6\u5408\u3044\u3092\u8a55\u4fa1\u3059\u308b\u3002<\/p>\n\n\n\n

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\"\"<\/figure>\n\n\n\n
\n
\n

2\uff09\u3088\u308a\u4f5c\u56f3<\/p>\n<\/div>\n\n\n\n

<\/div>\n\n\n\n
<\/div>\n<\/div>\n\n\n\n

\u25a0\u30b7\u30f3\u30b0\u30ec\u30a2\u00ae<\/sup>\u8ffd\u52a0\u6295\u4e0e\u5f8c\u306e\u5598\u606f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u6539\u5584\u52b9\u679c<\/h4>\n\n\n\n
\"\"<\/figure>\n\n\n\n
\n
\n

3\uff09\u3088\u308a\u4f5c\u56f3<\/p>\n<\/div>\n\n\n\n

<\/div>\n\n\n\n
<\/div>\n<\/div>\n\n\n\n

\u5b89\u5168\u6027<\/h3>\n\n\n\n

\u5168\u75c7\u4f8b1,681\u4f8b\u4e2d\u3001103\u4f8b177\u4ef6\uff08\u5168\u75c7\u4f8b\u306e\u3046\u30616.1\uff05\uff09\u306b\u6709\u5bb3\u4e8b\u8c61\u304c\u8a8d\u3081\u3089\u308c\u3001\u305d\u306e\u3046\u30619\u4f8b\u304c\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u3068\u3057\u3066\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u30021\u4f8b\u304c\u30b7\u30f3\u30b0\u30ec\u30a2\u00ae<\/sup>\u3068\u7121\u95a2\u9023\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u6557\u8840\u75c7\u6027\u30b7\u30e7\u30c3\u30af\u306b\u3088\u308b\u6b7b\u4ea1\u3001\u305d\u306e\u4ed6\u306f\u80c3\u764c\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u8089\u82bd\u816b\u6027\u8840\u7ba1\u708e\uff08\u30c1\u30e3\u30fc\u30b0\u30fb\u30b9\u30c8\u30e9\u30a6\u30b9\u75c7\u5019\u7fa4\uff09\u3001\u8180\u80f1\u764c\u3001\u534a\u6708\u677f\u75c5\u5909\u3001\u6c17\u7ba1\u652f\u708e\u3001\u5598\u606f\u3001\u304a\u3088\u3073\u624b\u306e\u9aa8\u6298\u3067\u3057\u305f\u3002\u6700\u3082\u591a\u304f\u767a\u73fe\u3057\u305f\u6709\u5bb3\u4e8b\u8c61\u306f\u3001\u611f\u67d3\uff0816\u4ef6\uff09\u3001\u5598\u606f(14\u4ef6\uff09\u3001\u9f3b\u54bd\u982d\u708e\uff088\u4ef6\uff09\u3001\u982d\u75db\uff087\u4ef6\uff09\u3001\u5614\u6c17\uff086\u4ef6\uff09\u3067\u3057\u305f\u3002\u30b7\u30f3\u30b0\u30ec\u30a2\u00ae<\/sup>\u3068\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u3001\u6709\u5bb3\u4e8b\u8c61177\u4ef6\u4e2d77\u4ef6\u306f\u300c\u95a2\u9023\u306a\u3057\u300d\u3082\u3057\u304f\u306f\u300c\u304a\u305d\u3089\u304f\u95a2\u9023\u306a\u3057\u300d\u3068\u5224\u5b9a\u3055\u308c\u300168\u4ef6\u306f\u300c\u95a2\u9023\u3042\u308a\u300d\u3082\u3057\u304f\u306f\u300c\u304a\u305d\u3089\u304f\u95a2\u9023\u3042\u308a\u300d\u3068\u5224\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u5c11\u306a\u304f\u3068\u3082\u30b7\u30f3\u30b0\u30ec\u30a2\u00ae<\/sup>\u306b\u95a2\u9023\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u6700\u3082\u4e00\u822c\u7684\u306a\u6709\u5bb3\u4e8b\u8c61\u306f\u3001\u767a\u75b9\u3001\u7761\u7720\u969c\u5bb3\u3001\u982d\u75db\u3001\u80f8\u3084\u3051\u3001\u5410\u304d\u6c17\u3067\u3057\u305f\u3002<\/strong><\/p>\n\n\n\n

\u3008\u5bfe\u8c61\u3009
18\u6b73\u4ee5\u4e0a\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u4e0d\u826f\u306e\u8efd\u75c7\u30fb\u4e2d\u7b49\u75c7\u5598\u606f\u60a3\u8005 1,681\u4f8b<\/p>\n\n\n\n

\u3008\u65b9\u6cd5\u3009
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\u3008\u8a55\u4fa1\u9805\u76ee\u3009
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\u3008\u89e3\u6790\u8a08\u753b\u3009
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2) Virchow JC et al. Respir Med<\/em> 2010\uff1b104\uff085\uff09\uff1a644-651.
\u3010\u5229\u76ca\u76f8\u53cd\u3011MSD\u793e\uff08\u4f1a\u793e\u5206\u5272\u306b\u3088\u308a\u30a6\u30a3\u30e1\u30f3\u30ba\u30d8\u30eb\u30b9\u53ca\u3073\u30ec\u30ac\u30b7\u30fc\u30d6\u30e9\u30f3\u30c9\u95a2\u9023\u306e\u7279\u5b9a\u306e\u88fd\u54c1\u306e\u4e8b\u696d\u306b\u95a2\u3059\u308b\u6a29\u5229\u7fa9\u52d9\u3092\u30aa\u30eb\u30ac\u30ce\u30f3\u682a\u5f0f\u4f1a\u793e\u306b\u627f\u7d99\u3055\u305b\u305f\u3002\u4ee5\u4e0b\u540c\u69d8\uff09\u304c\u672c\u7814\u7a76\u306b\u8cc7\u91d1\u63d0\u4f9b\u3002Virchow JC\u3068Mitfessel H\u306fMSD\u793e\u306e\u30a2\u30c9\u30d0\u30a4\u30b6\u30fc\u3067\u8b1b\u6f14\u6599\u53d7\u9818\u3002Mehta A\u306fMSD\u793e\u54e1\u3002

3) Virchow JC et al. J Asthma<\/em> 2010\uff1b47\uff089\uff09\uff1a986-993.
\u3010\u5229\u76ca\u76f8\u53cd\u3011MSD\u793e\uff08\u4f1a\u793e\u5206\u5272\u306b\u3088\u308a\u30a6\u30a3\u30e1\u30f3\u30ba\u30d8\u30eb\u30b9\u53ca\u3073\u30ec\u30ac\u30b7\u30fc\u30d6\u30e9\u30f3\u30c9\u95a2\u9023\u306e\u7279\u5b9a\u306e\u88fd\u54c1\u306e\u4e8b\u696d\u306b\u95a2\u3059\u308b\u6a29\u5229\u7fa9\u52d9\u3092\u30aa\u30eb\u30ac\u30ce\u30f3\u682a\u5f0f\u4f1a\u793e\u306b\u627f\u7d99\u3055\u305b\u305f\u3002\u4ee5\u4e0b\u540c\u69d8\uff09\u304c\u672c\u7814\u7a76\u306b\u8cc7\u91d1\u63d0\u4f9b\u3002Christian J\u3068Virchow JC\u306fMSD\u793e\u3088\u308a\u8b1b\u6f14\u6599\u3092\u53d7\u9818\u3002Mehta A\u306fMSD\u793e\u54e1\u3002<\/p>\n","protected":false},"author":27,"featured_media":0,"parent":126,"menu_order":2,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"product_categories":[],"product_specialization":[],"customer_type":[],"class_list":["post-130","product","type-product","status-publish","hentry"],"acf":[],"yoast_head":"\n\u5598\u606f\u3068\u9f3b\u708e\u306b\u5bfe\u3059\u308b\u52b9\u679c - Organon Pro - Japan<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/organonpro.com\/ja-jp\/product\/singulair\/pick-up\/effect\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u5598\u606f\u3068\u9f3b\u708e\u306b\u5bfe\u3059\u308b\u52b9\u679c\" \/>\n<meta property=\"og:description\" content=\"\u300c\u7981\u5fcc\u3092\u542b\u3080\u4f7f\u7528\u4e0a\u306e\u6ce8\u610f\u300d\u7b49\u306f\u88fd\u54c1\u6dfb\u4ed8\u6587\u66f8\u3092\u3054\u53c2\u7167\u304f\u3060\u3055\u3044\u3002 \u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u5b63\u7bc0\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306b\u5bfe\u3059\u308b\u6709\u7528\u6027 \u25a0\u5b89\u5168\u6027\u60c5\u5831\uff1a\u526f\u4f5c\u7528\u767a\u73fe\u72b6\u6cc1\u306e\u4e00\u89a7\uff08\u4f7f\u7528\u6210\u7e3e\u8abf\u67fb\uff09 \u526f\u4f5c\u7528\u540d\u306f\u65e5\u672c\u8a9e\u7248MedDRA\/J ver.14.1 \u3092\u4f7f\u7528\u3057\u305f\u3002\u6ce8\uff1a\u526f\u4f5c\u7528\u306e\u5668\u5b98\u5225\u5927\u5206\u985e\u306e\u96c6\u8a08\u306f\u767a\u73fe\u4f8b\u6570\u3001\u526f\u4f5c\u7528\u306e\u96c6\u8a08\u306f\u767a\u73fe\u4ef6\u6570\u3092\u793a\u3057\u305f\u3002 \u25a0\u6709\u52b9\u6027\u60c5\u5831 \uff1a\u5404\u9f3b\u75c7\u72b6\u306e\u672c\u5264\u4f7f\u7528\u306b\u3088\u308b\u5168\u822c\u7684\u5370\u8c61\uff08\u4f7f\u7528\u6210\u7e3e\u8abf\u67fb\uff09 1\uff09\u3088\u308a\u6539\u5909 \u3008\u5bfe\u8c61\u3009\u5b63\u7bc0\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u60a3\u8005\uff08\u5b89\u5168\u6027\u96c6\u8a08\u5bfe\u8c61\u75c7\u4f8b728 \u4f8b\u3001\u6709\u52b9\u6027\u96c6\u8a08\u5bfe\u8c61\u75c7\u4f8b692 \u4f8b\uff09 \u3008\u65b9\u6cd5\u3009\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306b\u5bfe\u3057\u3001\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u88fd\u5264\u3092\u627f\u8a8d\u3055\u308c\u305f\u7528\u6cd5\u30fb\u7528\u91cf\uff08\u901a\u5e38\u3001\u6210\u4eba\u306b\u306f\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u3068\u3057\u30665\uff5e10mg\u30921\u65e51\u56de\u5c31\u5bdd\u524d\u306b\u7d4c\u53e3\u6295\u4e0e\uff09\u3067\u65b0\u898f\u306b\u6295\u4e0e\u958b\u59cb\u3057\u305f\u3001\u5b63\u7bc0\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u3001\u8033\u9f3b\u79d1\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u79d1\u3001\u5185\u79d1\u3092\u6709\u3059\u308b\u533b\u7642\u6a5f\u95a2\u3067\u3001\u30d7\u30ed\u30b9\u30da\u30af\u30c6\u30a3\u30d6\u306a\u9023\u7d9a\u8abf\u67fb\u65b9\u5f0f\u306b\u3088\u308a\u8abf\u67fb\u3092\u5b9f\u65bd\u3057\u305f\u3002\u89b3\u5bdf\u671f\u9593\u306f\u6295\u4e0e\u958b\u59cb\u65e5\u304b\u3089\u6700\u7d42\u89b3\u5bdf\u65e5\u307e\u3067\u3068\u5b9a\u7fa9\u3057\u3001\u539f\u5247\u3068\u3057\u30662\u9031\u9593\u4ee5\u4e0a\u3068\u3057\u305f\u3002 \u3008\u8a55\u4fa1\u9805\u76ee\u3009\u65e5\u5e38\u8a3a\u7642\u306b\u304a\u3051\u308b\u4f7f\u7528\u5b9f\u614b\u4e0b\u306b\u304a\u3044\u3066\u5b63\u7bc0\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306b\u4f7f\u7528\u3055\u308c\u305f\u969b\u306e\u5b89\u5168\u6027\uff08\u6709\u5bb3\u4e8b\u8c61\uff09\u304a\u3088\u3073\u6709\u52b9\u6027\uff08\u5168\u822c\u6539\u5584\u5ea6\u3001\u5168\u822c\u7684\u5370\u8c61\uff09 \u3008\u89e3\u6790\u8a08\u753b\u3009\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u88fd\u5264\u306e\u5b89\u5168\u6027\u304a\u3088\u3073\u6709\u52b9\u6027\u306b\u95a2\u3059\u308b\u60c5\u5831\u306e\u96c6\u8a08\u3001\u89e3\u6790\u3092\u884c\u3063\u305f\u3002\u526f\u4f5c\u7528\u767a\u73fe\u72b6\u6cc1\u304a\u3088\u3073\u6709\u52b9\u7387\u306e\u60a3\u8005\u80cc\u666f\u5225\u306e\u5c64\u5225\u89e3\u6790\u3067\u306f\u3001\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u9806\u5e8f\u304c\u3042\u308b\u5e74\u9f62\u91cd\u75c7\u5ea6\u7f79\u75c5\u671f\u9593\u4f7f\u7528\u671f\u9593\u3001\u7dcf\u6295\u4e0e\u91cf\u306b\u3064\u3044\u3066\u306f\u3001Wilcoxon\u306e\u9806\u4f4d\u548c\u691c\u5b9a\u3092\u5b9f\u65bd\u3057\u305f\u3002\u305d\u308c\u4ee5\u5916\u306e\u9805\u76ee\u3067\u3001\u81ea\u7531\u5ea6(DF) = 1\u306e\u3068\u304d\u306fFisher\u306e\u76f4\u63a5\u78ba\u7387\u691c\u5b9a\u3001DF\u22672\u306e\u3068\u304d\u306f\u03c72\u691c\u5b9a\u3092\u5b9f\u65bd\u3057\u305f\u3002\u6709\u610f\u6c34\u6e96\u306f\u4e21\u50745\uff05\u3068\u3057\u305f\u3002 1\uff09\u4e39\u4e0b \u967d\u5b50 \u4ed6. \u65b0\u85ac\u3068\u81e8\u7240 2015; 64: 1334-1356.\u3088\u308a\u6539\u5909\u3010\u5229\u76ca\u76f8\u53cd\u3011\u672c\u8abf\u67fb\u306fMSD\u793e\uff08\u4f1a\u793e\u5206\u5272\u306b\u3088\u308a\u30a6\u30a3\u30e1\u30f3\u30ba\u30d8\u30eb\u30b9\u53ca\u3073\u30ec\u30ac\u30b7\u30fc\u30d6\u30e9\u30f3\u30c9\u95a2\u9023\u306e\u7279\u5b9a\u306e\u88fd\u54c1\u306e\u4e8b\u696d\u306b\u95a2\u3059\u308b\u6a29\u5229\u7fa9\u52d9\u3092\u30aa\u30eb\u30ac\u30ce\u30f3\u682a\u5f0f\u4f1a\u793e\u306b\u627f\u7d99\u3055\u305b\u305f\u3002\u4ee5\u4e0b\u540c\u69d8\uff09\u306b\u3088\u308a\u5b9f\u65bd\u3055\u308c\u305f\u3002\u8457\u8005\u306e\u3046\u3061\u4e39\u4e0b\u3001\u9577\u5d0e\u3001\u5c0f\u6cc9\u3001\u539f\u306fMSD\u793e\u54e1\u3002 \u901a\u5e74\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306b\u5bfe\u3059\u308b\u6709\u7528\u6027 \u25a0\u5b89\u5168\u6027\u60c5\u5831\uff1a\u526f\u4f5c\u7528\u767a\u73fe\u72b6\u6cc1\u306e\u4e00\u89a7\uff08\u7279\u5b9a\u4f7f\u7528\u6210\u7e3e\u8abf\u67fb\uff09 \uff0a\uff1a\u4f7f\u7528\u4e0a\u306e\u6ce8\u610f\u304b\u3089\u4e88\u6e2c\u3067\u304d\u306a\u3044\u526f\u4f5c\u7528\u526f\u4f5c\u7528\u540d\u306f\u65e5\u672c\u8a9e\u7248MedDRA\/J ver.14.1 \u3092\u4f7f\u7528\u3057\u305f\u3002\u6ce8\uff1a\u526f\u4f5c\u7528\u306e\u5668\u5b98\u5225\u5927\u5206\u985e\u306e\u96c6\u8a08\u306f\u767a\u73fe\u4f8b\u6570\u3001\u526f\u4f5c\u7528\u306e\u96c6\u8a08\u306f\u767a\u73fe\u4ef6\u6570\u3092\u793a\u3057\u305f\u3002 \u25a0\u6709\u52b9\u6027\u60c5\u5831 \uff1a\u5404\u9f3b\u75c7\u72b6\u306e\u672c\u5264\u4f7f\u7528\u306b\u3088\u308b\u5168\u822c\u7684\u5370\u8c61\uff08\u7279\u5b9a\u4f7f\u7528\u6210\u7e3e\u8abf\u67fb\uff09 1\uff09\u3088\u308a\u6539\u5909 \u3008\u5bfe\u8c61\u3009\u901a\u5e74\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u60a3\u8005\uff08\u5b89\u5168\u6027\u96c6\u8a08\u5bfe\u8c61\u75c7\u4f8b637\u4f8b\u3001\u6709\u52b9\u6027\u96c6\u8a08\u5bfe\u8c61\u75c7\u4f8b583\u4f8b\uff09 \u3008\u65b9\u6cd5\u3009\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306b\u5bfe\u3057\u3001\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u88fd\u5264\u3092\u627f\u8a8d\u3055\u308c\u305f\u7528\u6cd5\u30fb\u7528\u91cf\uff08\u901a\u5e38\u3001\u6210\u4eba\u306b\u306f\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u3068\u3057\u30665\uff5e10mg\u30921\u65e51\u56de\u5c31\u5bdd\u524d\u306b\u7d4c\u53e3\u6295\u4e0e\uff09 \u3067\u65b0\u898f\u306b\u6295\u4e0e\u958b\u59cb\u3057\u305f\u3001\u8033\u9f3b\u79d1\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u79d1\u3001\u5185\u79d1\u3092\u6709\u3059\u308b\u533b\u7642\u6a5f\u95a2\u3067\u3001\u30d7\u30ed\u30b9\u30da\u30af\u30c6\u30a3\u30d6\u306a\u9023\u7d9a\u8abf\u67fb\u65b9\u5f0f\u306b\u3088\u308a\u8abf\u67fb\u3092\u5b9f\u65bd\u3057\u305f\u3002\u89b3\u5bdf\u671f\u9593\u306f\u6295\u4e0e\u958b\u59cb\u65e5\u304b\u3089\u6700\u7d42\u89b3\u5bdf\u65e5\u307e\u3067\u3068\u5b9a\u7fa9\u3057\u3001\u539f\u5247\u3068\u3057\u306612\u9031\u9593\u4ee5\u4e0a\u3068\u3057\u305f\u3002 \u3008\u8a55\u4fa1\u9805\u76ee\u3009\u65e5\u5e38\u8a3a\u7642\u306b\u304a\u3051\u308b\u4f7f\u7528\u5b9f\u614b\u4e0b\u306b\u304a\u3044\u3066\u901a\u5e74\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306b\u9577\u671f\u4f7f\u7528\u3055\u308c\u305f\u969b\u306e\u5b89\u5168\u6027\uff08\u6709\u5bb3\u4e8b\u8c61\uff09\u304a\u3088\u3073\u6709\u52b9\u6027\uff08\u5168\u822c\u6539\u5584\u5ea6\u3001\u5168\u822c\u7684\u5370\u8c61\uff09 \u3008\u89e3\u6790\u8a08\u753b\u3009\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u88fd\u5264\u306e\u5b89\u5168\u6027\u304a\u3088\u3073\u6709\u52b9\u6027\u306b\u95a2\u3059\u308b\u60c5\u5831\u306e\u96c6\u8a08\u3001\u89e3\u6790\u3092\u884c\u3063\u305f\u3002\u526f\u4f5c\u7528\u767a\u73fe\u72b6\u6cc1\u304a\u3088\u3073\u6709\u52b9\u7387\u306e\u60a3\u8005\u80cc\u666f\u5225\u306e\u5c64\u5225\u89e3\u6790\u3067\u306f\u3001\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u9806\u5e8f\u304c\u3042\u308b\u5e74\u9f62\u91cd\u75c7\u5ea6\u7f79\u75c5\u671f\u9593\u4f7f\u7528\u671f\u9593\u3001\u7dcf\u6295\u4e0e\u91cf\u306b\u3064\u3044\u3066\u306f\u3001Wilcoxon\u306e\u9806\u4f4d\u548c\u691c\u5b9a\u3092\u5b9f\u65bd\u3057\u305f\u3002\u305d\u308c\u4ee5\u5916\u306e\u9805\u76ee\u3067\u3001\u81ea\u7531\u5ea6(DF) = 1\u306e\u3068\u304d\u306fFisher\u306e\u76f4\u63a5\u78ba\u7387\u691c\u5b9a\u3001 DF\u22672\u306e\u3068\u304d\u306f\u03c72\u691c\u5b9a\u3092\u5b9f\u65bd\u3057\u305f\u3002\u6709\u610f\u6c34\u6e96\u306f\u4e21\u50745\uff05\u3068\u3057\u305f\u3002 1\uff09\u4e39\u4e0b \u967d\u5b50 \u4ed6. \u65b0\u85ac\u3068\u81e8\u7240 2015; 64: 1334-1356\u3010\u5229\u76ca\u76f8\u53cd\u3011\u672c\u8abf\u67fb\u306fMSD\u793e\uff08\u4f1a\u793e\u5206\u5272\u306b\u3088\u308a\u30a6\u30a3\u30e1\u30f3\u30ba\u30d8\u30eb\u30b9\u53ca\u3073\u30ec\u30ac\u30b7\u30fc\u30d6\u30e9\u30f3\u30c9\u95a2\u9023\u306e\u7279\u5b9a\u306e\u88fd\u54c1\u306e\u4e8b\u696d\u306b\u95a2\u3059\u308b\u6a29\u5229\u7fa9\u52d9\u3092\u30aa\u30eb\u30ac\u30ce\u30f3\u682a\u5f0f\u4f1a\u793e\u306b\u627f\u7d99\u3055\u305b\u305f\u3002\u4ee5\u4e0b\u540c\u69d8\uff09\u306b\u3088\u308a\u5b9f\u65bd\u3055\u308c\u305f\u3002\u8457\u8005\u306e\u3046\u3061\u4e39\u4e0b\u3001\u9577\u5d0e\u3001\u5c0f\u6cc9\u3001\u539f\u306fMSD\u793e\u54e1\u3002 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\u3067\u65b0\u898f\u306b\u6295\u4e0e\u958b\u59cb\u3057\u305f\u3001\u8033\u9f3b\u79d1\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u79d1\u3001\u5185\u79d1\u3092\u6709\u3059\u308b\u533b\u7642\u6a5f\u95a2\u3067\u3001\u30d7\u30ed\u30b9\u30da\u30af\u30c6\u30a3\u30d6\u306a\u9023\u7d9a\u8abf\u67fb\u65b9\u5f0f\u306b\u3088\u308a\u8abf\u67fb\u3092\u5b9f\u65bd\u3057\u305f\u3002\u89b3\u5bdf\u671f\u9593\u306f\u6295\u4e0e\u958b\u59cb\u65e5\u304b\u3089\u6700\u7d42\u89b3\u5bdf\u65e5\u307e\u3067\u3068\u5b9a\u7fa9\u3057\u3001\u539f\u5247\u3068\u3057\u306612\u9031\u9593\u4ee5\u4e0a\u3068\u3057\u305f\u3002 \u3008\u8a55\u4fa1\u9805\u76ee\u3009\u65e5\u5e38\u8a3a\u7642\u306b\u304a\u3051\u308b\u4f7f\u7528\u5b9f\u614b\u4e0b\u306b\u304a\u3044\u3066\u901a\u5e74\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306b\u9577\u671f\u4f7f\u7528\u3055\u308c\u305f\u969b\u306e\u5b89\u5168\u6027\uff08\u6709\u5bb3\u4e8b\u8c61\uff09\u304a\u3088\u3073\u6709\u52b9\u6027\uff08\u5168\u822c\u6539\u5584\u5ea6\u3001\u5168\u822c\u7684\u5370\u8c61\uff09 \u3008\u89e3\u6790\u8a08\u753b\u3009\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u88fd\u5264\u306e\u5b89\u5168\u6027\u304a\u3088\u3073\u6709\u52b9\u6027\u306b\u95a2\u3059\u308b\u60c5\u5831\u306e\u96c6\u8a08\u3001\u89e3\u6790\u3092\u884c\u3063\u305f\u3002\u526f\u4f5c\u7528\u767a\u73fe\u72b6\u6cc1\u304a\u3088\u3073\u6709\u52b9\u7387\u306e\u60a3\u8005\u80cc\u666f\u5225\u306e\u5c64\u5225\u89e3\u6790\u3067\u306f\u3001\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u9806\u5e8f\u304c\u3042\u308b\u5e74\u9f62\u91cd\u75c7\u5ea6\u7f79\u75c5\u671f\u9593\u4f7f\u7528\u671f\u9593\u3001\u7dcf\u6295\u4e0e\u91cf\u306b\u3064\u3044\u3066\u306f\u3001Wilcoxon\u306e\u9806\u4f4d\u548c\u691c\u5b9a\u3092\u5b9f\u65bd\u3057\u305f\u3002\u305d\u308c\u4ee5\u5916\u306e\u9805\u76ee\u3067\u3001\u81ea\u7531\u5ea6(DF) = 1\u306e\u3068\u304d\u306fFisher\u306e\u76f4\u63a5\u78ba\u7387\u691c\u5b9a\u3001 DF\u22672\u306e\u3068\u304d\u306f\u03c72\u691c\u5b9a\u3092\u5b9f\u65bd\u3057\u305f\u3002\u6709\u610f\u6c34\u6e96\u306f\u4e21\u50745\uff05\u3068\u3057\u305f\u3002 […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/organonpro.com\/ja-jp\/product\/singulair\/pick-up\/effect\/\" \/>\n<meta property=\"og:site_name\" content=\"Organon Pro - Japan\" \/>\n<meta property=\"article:modified_time\" content=\"2024-08-13T12:19:03+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/organonpro.com\/ja-jp\/wp-content\/uploads\/sites\/10\/2022\/08\/singulair-img11_tcm5682-842262.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" 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\u3008\u65b9\u6cd5\u3009\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306b\u5bfe\u3057\u3001\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u88fd\u5264\u3092\u627f\u8a8d\u3055\u308c\u305f\u7528\u6cd5\u30fb\u7528\u91cf\uff08\u901a\u5e38\u3001\u6210\u4eba\u306b\u306f\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u3068\u3057\u30665\uff5e10mg\u30921\u65e51\u56de\u5c31\u5bdd\u524d\u306b\u7d4c\u53e3\u6295\u4e0e\uff09\u3067\u65b0\u898f\u306b\u6295\u4e0e\u958b\u59cb\u3057\u305f\u3001\u5b63\u7bc0\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u3001\u8033\u9f3b\u79d1\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u79d1\u3001\u5185\u79d1\u3092\u6709\u3059\u308b\u533b\u7642\u6a5f\u95a2\u3067\u3001\u30d7\u30ed\u30b9\u30da\u30af\u30c6\u30a3\u30d6\u306a\u9023\u7d9a\u8abf\u67fb\u65b9\u5f0f\u306b\u3088\u308a\u8abf\u67fb\u3092\u5b9f\u65bd\u3057\u305f\u3002\u89b3\u5bdf\u671f\u9593\u306f\u6295\u4e0e\u958b\u59cb\u65e5\u304b\u3089\u6700\u7d42\u89b3\u5bdf\u65e5\u307e\u3067\u3068\u5b9a\u7fa9\u3057\u3001\u539f\u5247\u3068\u3057\u30662\u9031\u9593\u4ee5\u4e0a\u3068\u3057\u305f\u3002 \u3008\u8a55\u4fa1\u9805\u76ee\u3009\u65e5\u5e38\u8a3a\u7642\u306b\u304a\u3051\u308b\u4f7f\u7528\u5b9f\u614b\u4e0b\u306b\u304a\u3044\u3066\u5b63\u7bc0\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306b\u4f7f\u7528\u3055\u308c\u305f\u969b\u306e\u5b89\u5168\u6027\uff08\u6709\u5bb3\u4e8b\u8c61\uff09\u304a\u3088\u3073\u6709\u52b9\u6027\uff08\u5168\u822c\u6539\u5584\u5ea6\u3001\u5168\u822c\u7684\u5370\u8c61\uff09 \u3008\u89e3\u6790\u8a08\u753b\u3009\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u88fd\u5264\u306e\u5b89\u5168\u6027\u304a\u3088\u3073\u6709\u52b9\u6027\u306b\u95a2\u3059\u308b\u60c5\u5831\u306e\u96c6\u8a08\u3001\u89e3\u6790\u3092\u884c\u3063\u305f\u3002\u526f\u4f5c\u7528\u767a\u73fe\u72b6\u6cc1\u304a\u3088\u3073\u6709\u52b9\u7387\u306e\u60a3\u8005\u80cc\u666f\u5225\u306e\u5c64\u5225\u89e3\u6790\u3067\u306f\u3001\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u9806\u5e8f\u304c\u3042\u308b\u5e74\u9f62\u91cd\u75c7\u5ea6\u7f79\u75c5\u671f\u9593\u4f7f\u7528\u671f\u9593\u3001\u7dcf\u6295\u4e0e\u91cf\u306b\u3064\u3044\u3066\u306f\u3001Wilcoxon\u306e\u9806\u4f4d\u548c\u691c\u5b9a\u3092\u5b9f\u65bd\u3057\u305f\u3002\u305d\u308c\u4ee5\u5916\u306e\u9805\u76ee\u3067\u3001\u81ea\u7531\u5ea6(DF) = 1\u306e\u3068\u304d\u306fFisher\u306e\u76f4\u63a5\u78ba\u7387\u691c\u5b9a\u3001DF\u22672\u306e\u3068\u304d\u306f\u03c72\u691c\u5b9a\u3092\u5b9f\u65bd\u3057\u305f\u3002\u6709\u610f\u6c34\u6e96\u306f\u4e21\u50745\uff05\u3068\u3057\u305f\u3002 1\uff09\u4e39\u4e0b \u967d\u5b50 \u4ed6. \u65b0\u85ac\u3068\u81e8\u7240 2015; 64: 1334-1356.\u3088\u308a\u6539\u5909\u3010\u5229\u76ca\u76f8\u53cd\u3011\u672c\u8abf\u67fb\u306fMSD\u793e\uff08\u4f1a\u793e\u5206\u5272\u306b\u3088\u308a\u30a6\u30a3\u30e1\u30f3\u30ba\u30d8\u30eb\u30b9\u53ca\u3073\u30ec\u30ac\u30b7\u30fc\u30d6\u30e9\u30f3\u30c9\u95a2\u9023\u306e\u7279\u5b9a\u306e\u88fd\u54c1\u306e\u4e8b\u696d\u306b\u95a2\u3059\u308b\u6a29\u5229\u7fa9\u52d9\u3092\u30aa\u30eb\u30ac\u30ce\u30f3\u682a\u5f0f\u4f1a\u793e\u306b\u627f\u7d99\u3055\u305b\u305f\u3002\u4ee5\u4e0b\u540c\u69d8\uff09\u306b\u3088\u308a\u5b9f\u65bd\u3055\u308c\u305f\u3002\u8457\u8005\u306e\u3046\u3061\u4e39\u4e0b\u3001\u9577\u5d0e\u3001\u5c0f\u6cc9\u3001\u539f\u306fMSD\u793e\u54e1\u3002 \u901a\u5e74\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306b\u5bfe\u3059\u308b\u6709\u7528\u6027 \u25a0\u5b89\u5168\u6027\u60c5\u5831\uff1a\u526f\u4f5c\u7528\u767a\u73fe\u72b6\u6cc1\u306e\u4e00\u89a7\uff08\u7279\u5b9a\u4f7f\u7528\u6210\u7e3e\u8abf\u67fb\uff09 \uff0a\uff1a\u4f7f\u7528\u4e0a\u306e\u6ce8\u610f\u304b\u3089\u4e88\u6e2c\u3067\u304d\u306a\u3044\u526f\u4f5c\u7528\u526f\u4f5c\u7528\u540d\u306f\u65e5\u672c\u8a9e\u7248MedDRA\/J ver.14.1 \u3092\u4f7f\u7528\u3057\u305f\u3002\u6ce8\uff1a\u526f\u4f5c\u7528\u306e\u5668\u5b98\u5225\u5927\u5206\u985e\u306e\u96c6\u8a08\u306f\u767a\u73fe\u4f8b\u6570\u3001\u526f\u4f5c\u7528\u306e\u96c6\u8a08\u306f\u767a\u73fe\u4ef6\u6570\u3092\u793a\u3057\u305f\u3002 \u25a0\u6709\u52b9\u6027\u60c5\u5831 \uff1a\u5404\u9f3b\u75c7\u72b6\u306e\u672c\u5264\u4f7f\u7528\u306b\u3088\u308b\u5168\u822c\u7684\u5370\u8c61\uff08\u7279\u5b9a\u4f7f\u7528\u6210\u7e3e\u8abf\u67fb\uff09 1\uff09\u3088\u308a\u6539\u5909 \u3008\u5bfe\u8c61\u3009\u901a\u5e74\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u60a3\u8005\uff08\u5b89\u5168\u6027\u96c6\u8a08\u5bfe\u8c61\u75c7\u4f8b637\u4f8b\u3001\u6709\u52b9\u6027\u96c6\u8a08\u5bfe\u8c61\u75c7\u4f8b583\u4f8b\uff09 \u3008\u65b9\u6cd5\u3009\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306b\u5bfe\u3057\u3001\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u88fd\u5264\u3092\u627f\u8a8d\u3055\u308c\u305f\u7528\u6cd5\u30fb\u7528\u91cf\uff08\u901a\u5e38\u3001\u6210\u4eba\u306b\u306f\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u3068\u3057\u30665\uff5e10mg\u30921\u65e51\u56de\u5c31\u5bdd\u524d\u306b\u7d4c\u53e3\u6295\u4e0e\uff09 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\u3008\u8a55\u4fa1\u9805\u76ee\u3009\u65e5\u5e38\u8a3a\u7642\u306b\u304a\u3051\u308b\u4f7f\u7528\u5b9f\u614b\u4e0b\u306b\u304a\u3044\u3066\u901a\u5e74\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306b\u9577\u671f\u4f7f\u7528\u3055\u308c\u305f\u969b\u306e\u5b89\u5168\u6027\uff08\u6709\u5bb3\u4e8b\u8c61\uff09\u304a\u3088\u3073\u6709\u52b9\u6027\uff08\u5168\u822c\u6539\u5584\u5ea6\u3001\u5168\u822c\u7684\u5370\u8c61\uff09 \u3008\u89e3\u6790\u8a08\u753b\u3009\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u88fd\u5264\u306e\u5b89\u5168\u6027\u304a\u3088\u3073\u6709\u52b9\u6027\u306b\u95a2\u3059\u308b\u60c5\u5831\u306e\u96c6\u8a08\u3001\u89e3\u6790\u3092\u884c\u3063\u305f\u3002\u526f\u4f5c\u7528\u767a\u73fe\u72b6\u6cc1\u304a\u3088\u3073\u6709\u52b9\u7387\u306e\u60a3\u8005\u80cc\u666f\u5225\u306e\u5c64\u5225\u89e3\u6790\u3067\u306f\u3001\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u9806\u5e8f\u304c\u3042\u308b\u5e74\u9f62\u91cd\u75c7\u5ea6\u7f79\u75c5\u671f\u9593\u4f7f\u7528\u671f\u9593\u3001\u7dcf\u6295\u4e0e\u91cf\u306b\u3064\u3044\u3066\u306f\u3001Wilcoxon\u306e\u9806\u4f4d\u548c\u691c\u5b9a\u3092\u5b9f\u65bd\u3057\u305f\u3002\u305d\u308c\u4ee5\u5916\u306e\u9805\u76ee\u3067\u3001\u81ea\u7531\u5ea6(DF) = 1\u306e\u3068\u304d\u306fFisher\u306e\u76f4\u63a5\u78ba\u7387\u691c\u5b9a\u3001 DF\u22672\u306e\u3068\u304d\u306f\u03c72\u691c\u5b9a\u3092\u5b9f\u65bd\u3057\u305f\u3002\u6709\u610f\u6c34\u6e96\u306f\u4e21\u50745\uff05\u3068\u3057\u305f\u3002 1\uff09\u4e39\u4e0b \u967d\u5b50 \u4ed6. \u65b0\u85ac\u3068\u81e8\u7240 2015; 64: 1334-1356\u3010\u5229\u76ca\u76f8\u53cd\u3011\u672c\u8abf\u67fb\u306fMSD\u793e\uff08\u4f1a\u793e\u5206\u5272\u306b\u3088\u308a\u30a6\u30a3\u30e1\u30f3\u30ba\u30d8\u30eb\u30b9\u53ca\u3073\u30ec\u30ac\u30b7\u30fc\u30d6\u30e9\u30f3\u30c9\u95a2\u9023\u306e\u7279\u5b9a\u306e\u88fd\u54c1\u306e\u4e8b\u696d\u306b\u95a2\u3059\u308b\u6a29\u5229\u7fa9\u52d9\u3092\u30aa\u30eb\u30ac\u30ce\u30f3\u682a\u5f0f\u4f1a\u793e\u306b\u627f\u7d99\u3055\u305b\u305f\u3002\u4ee5\u4e0b\u540c\u69d8\uff09\u306b\u3088\u308a\u5b9f\u65bd\u3055\u308c\u305f\u3002\u8457\u8005\u306e\u3046\u3061\u4e39\u4e0b\u3001\u9577\u5d0e\u3001\u5c0f\u6cc9\u3001\u539f\u306fMSD\u793e\u54e1\u3002 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\u3067\u65b0\u898f\u306b\u6295\u4e0e\u958b\u59cb\u3057\u305f\u3001\u8033\u9f3b\u79d1\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u79d1\u3001\u5185\u79d1\u3092\u6709\u3059\u308b\u533b\u7642\u6a5f\u95a2\u3067\u3001\u30d7\u30ed\u30b9\u30da\u30af\u30c6\u30a3\u30d6\u306a\u9023\u7d9a\u8abf\u67fb\u65b9\u5f0f\u306b\u3088\u308a\u8abf\u67fb\u3092\u5b9f\u65bd\u3057\u305f\u3002\u89b3\u5bdf\u671f\u9593\u306f\u6295\u4e0e\u958b\u59cb\u65e5\u304b\u3089\u6700\u7d42\u89b3\u5bdf\u65e5\u307e\u3067\u3068\u5b9a\u7fa9\u3057\u3001\u539f\u5247\u3068\u3057\u306612\u9031\u9593\u4ee5\u4e0a\u3068\u3057\u305f\u3002 \u3008\u8a55\u4fa1\u9805\u76ee\u3009\u65e5\u5e38\u8a3a\u7642\u306b\u304a\u3051\u308b\u4f7f\u7528\u5b9f\u614b\u4e0b\u306b\u304a\u3044\u3066\u901a\u5e74\u6027\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306b\u9577\u671f\u4f7f\u7528\u3055\u308c\u305f\u969b\u306e\u5b89\u5168\u6027\uff08\u6709\u5bb3\u4e8b\u8c61\uff09\u304a\u3088\u3073\u6709\u52b9\u6027\uff08\u5168\u822c\u6539\u5584\u5ea6\u3001\u5168\u822c\u7684\u5370\u8c61\uff09 \u3008\u89e3\u6790\u8a08\u753b\u3009\u30e2\u30f3\u30c6\u30eb\u30ab\u30b9\u30c8\u88fd\u5264\u306e\u5b89\u5168\u6027\u304a\u3088\u3073\u6709\u52b9\u6027\u306b\u95a2\u3059\u308b\u60c5\u5831\u306e\u96c6\u8a08\u3001\u89e3\u6790\u3092\u884c\u3063\u305f\u3002\u526f\u4f5c\u7528\u767a\u73fe\u72b6\u6cc1\u304a\u3088\u3073\u6709\u52b9\u7387\u306e\u60a3\u8005\u80cc\u666f\u5225\u306e\u5c64\u5225\u89e3\u6790\u3067\u306f\u3001\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u9806\u5e8f\u304c\u3042\u308b\u5e74\u9f62\u91cd\u75c7\u5ea6\u7f79\u75c5\u671f\u9593\u4f7f\u7528\u671f\u9593\u3001\u7dcf\u6295\u4e0e\u91cf\u306b\u3064\u3044\u3066\u306f\u3001Wilcoxon\u306e\u9806\u4f4d\u548c\u691c\u5b9a\u3092\u5b9f\u65bd\u3057\u305f\u3002\u305d\u308c\u4ee5\u5916\u306e\u9805\u76ee\u3067\u3001\u81ea\u7531\u5ea6(DF) = 1\u306e\u3068\u304d\u306fFisher\u306e\u76f4\u63a5\u78ba\u7387\u691c\u5b9a\u3001 DF\u22672\u306e\u3068\u304d\u306f\u03c72\u691c\u5b9a\u3092\u5b9f\u65bd\u3057\u305f\u3002\u6709\u610f\u6c34\u6e96\u306f\u4e21\u50745\uff05\u3068\u3057\u305f\u3002 […]","og_url":"https:\/\/organonpro.com\/ja-jp\/product\/singulair\/pick-up\/effect\/","og_site_name":"Organon Pro - Japan","article_modified_time":"2024-08-13T12:19:03+00:00","og_image":[{"url":"https:\/\/organonpro.com\/ja-jp\/wp-content\/uploads\/sites\/10\/2022\/08\/singulair-img11_tcm5682-842262.jpg","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/organonpro.com\/ja-jp\/product\/singulair\/pick-up\/effect\/","url":"https:\/\/organonpro.com\/ja-jp\/product\/singulair\/pick-up\/effect\/","name":"\u5598\u606f\u3068\u9f3b\u708e\u306b\u5bfe\u3059\u308b\u52b9\u679c - Organon Pro - 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