{"id":5771,"date":"2023-06-06T06:41:11","date_gmt":"2023-06-06T06:41:11","guid":{"rendered":"https:\/\/organonpro.com\/en-us\/product\/formulation\/"},"modified":"2024-09-25T07:46:15","modified_gmt":"2024-09-25T07:46:15","slug":"formulation","status":"publish","type":"product","link":"https:\/\/organonpro.com\/en-us\/product\/xaciato\/formulation\/","title":{"rendered":"Formulation"},"content":{"rendered":"\n<h2 class=\"wp-block-heading has-text-align-left\" style=\"font-size:22px\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#dc646e\" class=\"has-inline-color\">Thermosetting formulation for gradual release of clindamycin<sup><strong>1<\/strong><\/sup><\/mark><\/h2>\n\n\n\n<p>XACIATO vaginal gel increases viscosity at body temperature and gradually releases clindamycin over time.<sup>a<\/sup><\/p>\n\n\n\n<p class=\"has-small-font-size\"><em>Click video below to learn more about <\/em>XACIATO<em>.<\/em><\/p>\n\n\n\n<div style=\"max-width: 720px;\">\n  <style>\n  video-js.video-js.vjs-fluid:not(.vjs-audio-only-mode) {\n    padding-top: 56.25%;\n  }\n  <\/style><video-js\n    data-account=\"6241154135001\"\n    data-player=\"A4vP85Hh4\"\n    data-embed=\"default\"\n    controls=\"\"\n    data-video-id=\"6331540440112\"\n    data-playlist-id=\"\"\n    data-application-id=\"\"\n    class=\"vjs-fluid\"><\/video-js>\n<\/div>\n<script\n  src=\"https:\/\/players.brightcove.net\/6241154135001\/A4vP85Hh4_default\/index.min.js\">\n<\/script>\n\n\n\n<p class=\"has-small-font-size\"><sup>a<\/sup>Based on an in vitro study using clindamycin HCl.<sup>1<\/sup><\/p>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-left\" style=\"font-size:22px\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#dc646e\" class=\"has-inline-color\">Formulated with the goal of limiting leakage and increasing vaginal retention time<sup>2<\/sup><\/mark><\/h2>\n\n\n\n<h3 class=\"wp-block-heading has-text-color\" style=\"color:#544556;font-size:18px\">Pathophysiology of BV<\/h3>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2023\/07\/1.png\" alt=\"\"\/><\/figure>\n\n\n\n<p>The normal vagina contains a microbiota dominated by <em><mark style=\"background-color:rgba(0, 0, 0, 0);color:#838dc7\" class=\"has-inline-color\"><strong>Lactobacillus<\/strong><\/mark><\/em> species.<sup>5<\/sup><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2023\/07\/2.png\" alt=\"\"\/><\/figure>\n\n\n\n<p>BV is characterized by a displacement of <em><mark style=\"background-color:rgba(0, 0, 0, 0);color:#838dc7\" class=\"has-inline-color\"><strong>Lactobacillus<\/strong><\/mark><\/em> and an increase in anaerobic bacteria, often as part of a<strong> biofilm<\/strong>.<sup>5,6<\/sup><\/p>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-pale-pink-color has-alpha-channel-opacity has-pale-pink-background-color has-background is-style-dots\"\/>\n\n\n\n<h3 class=\"wp-block-heading\" style=\"font-size:22px\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#544556\" class=\"has-inline-color\">Thermosetting formulation<sup><strong>1<\/strong><\/sup><\/mark><\/h3>\n\n\n\n<p class=\"has-text-color\" style=\"color:#dc646e;font-size:18px\"><strong>As demonstrated by an in vitro study<\/strong><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2023\/07\/3.png\" alt=\"\"\/><\/figure>\n\n\n\n<p>The gel exhibits <mark style=\"background-color:rgba(0, 0, 0, 0);color:#dc646e\" class=\"has-inline-color\"><strong>mucoadhesive<\/strong><\/mark> properties that may help it adhere to the vaginal wall.<br><br>The gel is less viscous at lower temperatures, which may permit the gel to coat and conform to the shape of the vaginal wall during the introduction of XACIATO.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2023\/07\/4.png\" alt=\"\"\/><\/figure>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:60px\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2023\/06\/HSCI-P005381-ORG-Figure14-2.png\" alt=\"\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>The specifically formulated gel in XACIATO <mark style=\"background-color:rgba(0, 0, 0, 0);color:#dc646e\" class=\"has-inline-color\"><strong>thermosets at body<\/strong> <strong>temperature<\/strong><\/mark>. This increase in viscosity may help XACIATO stay in place in the vagina.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:60px\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2023\/06\/HSCI-P005381-ORG-Figure15-1.png\" alt=\"\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p><mark style=\"background-color:rgba(0, 0, 0, 0);color:#dc646e\" class=\"has-inline-color\"><strong>Clindamycin is released<\/strong> <\/mark>from the gel <mark style=\"background-color:rgba(0, 0, 0, 0);color:#dc646e\" class=\"has-inline-color\"><strong>over<\/strong><\/mark> <mark style=\"background-color:rgba(0, 0, 0, 0);color:#dc646e\" class=\"has-inline-color\"><strong>time<\/strong><\/mark>, reaching a peak at days 2 and 3.<sup>b<\/sup><\/p>\n\n\n\n<p class=\"has-small-font-size\"><sup>b<\/sup>Clindamycin HCl was used in this study.<\/p>\n\n\n\n<p class=\"has-small-font-size\">BV = bacterial vaginosis; HCl = hydrochloride.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"author":68,"featured_media":0,"parent":5760,"menu_order":5,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"product_categories":[],"product_specialization":[],"customer_type":[],"class_list":["post-5771","product","type-product","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.11 (Yoast SEO v26.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Formulation of XACIATO\u2122 (clindamycin phosphate) 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