{"id":11092,"date":"2026-01-12T03:39:13","date_gmt":"2026-01-12T03:39:13","guid":{"rendered":"https:\/\/organonpro.com\/en-us\/product\/tofidence\/dosing-calculator-2\/"},"modified":"2026-07-15T12:08:45","modified_gmt":"2026-07-15T12:08:45","slug":"dosing-calculator","status":"publish","type":"product","link":"https:\/\/organonpro.com\/en-us\/product\/tofidence\/dosing-calculator\/","title":{"rendered":"Dosing Calculator"},"content":{"rendered":"\n<h1 class=\"wp-block-heading has-text-align-center has-text-color has-link-color wp-elements-f87a676643423dd7054bae31acc981ca\" id=\"h-tofidence-iv-infusion-dosing-calculator\" style=\"color:#0075be\">TOFIDENCE IV Infusion Dosing Calculator<\/h1>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center seo-heading-two-title has-text-color has-link-color wp-elements-03cec51b16601e5372ea6a92ccd416b2\" id=\"h-the-dosing-calculator-below-can-be-used-to-determine-tofidence-iv-infusion-dosing-based-on-individual-patient-weight\" style=\"color:#171717\">The dosing calculator below can be used to determine TOFIDENCE<br>IV infusion dosing based on individual patient weight.<\/h2>\n\n\n\n<div style=\"height:12px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center left-text-mobile has-text-color has-link-color wp-elements-9da7a26a733226f9bc3ab47ebd45d4ca wp-block-paragraph\" style=\"color:#171717;font-size:15px\"><span style=\"text-decoration:underline\">Not Recommended for Concomitant Use with Biological Disease-Modifying Anti-Rheumatic Drugs (DMARDs).<\/span><br>Tocilizumab products have not been studied in combination with biological DMARDs such as tumor necrosis factor (TNF) antagonists, interleukin-1 receptor (IL-1R) antagonists, anti-CD20 monoclonal antibodies, and selective co-stimulation modulators because of the possibility of increased immunosuppression and increased risk of infection. Avoid using TOFIDENCE with biological DMARDs.<br><br>Please see <a style=\"text-decoration: underline;color:#809D15\" href=\"https:\/\/www.organon.com\/product\/usa\/pi_circulars\/t\/tofidence\/Tofidence_PI.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Prescribing Information<\/a> for laboratory testing needed prior to treatment with TOFIDENCE as well as full dosing information for additional indications.<\/p>\n\n\n\n<div style=\"height:24px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 id=\"h-start-by-selecting-the-appropriate-indication-on-the-tabs-below\" class=\"wp-block-heading has-text-color has-link-color wp-elements-eab21a85943afb32cac388cf425c7228\" style=\"color:#171717\">Start by selecting the appropriate indication on the tabs below.<\/h5>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">        <div class=\"dosing-calculator\">\n            <ul class=\"nav nav-tabs nav-justified\" id=\"myTab\" role=\"tablist\">\n                <li class=\"nav-item\" role=\"presentation\">\n                    <button class=\"nav-link active\" id=\"ra-tab\" data-bs-toggle=\"tab\" data-bs-target=\"#RA\" type=\"button\" role=\"tab\" aria-controls=\"ra\" aria-selected=\"true\">RA<\/button>\n                <\/li>\n                <li class=\"nav-item\" role=\"presentation\">\n                    <button class=\"nav-link\" id=\"gca-tab\" data-bs-toggle=\"tab\" data-bs-target=\"#GCA\" type=\"button\" role=\"tab\" aria-controls=\"gca\" aria-selected=\"false\">GCA<\/button>\n                <\/li>\n                <li class=\"nav-item\" role=\"presentation\">\n                    <button class=\"nav-link\" id=\"pjia-tab\" data-bs-toggle=\"tab\" data-bs-target=\"#PJIA\" type=\"button\" role=\"tab\" aria-controls=\"pjia\" aria-selected=\"false\">PJIA<\/button>\n                <\/li>\n                <li class=\"nav-item\" role=\"presentation\">\n                    <button class=\"nav-link\" id=\"sjia-tab\" data-bs-toggle=\"tab\" data-bs-target=\"#SJIA\" type=\"button\" role=\"tab\" aria-controls=\"sjia\" aria-selected=\"false\">SJIA<\/button>\n                <\/li>\n            <\/ul>\n            <div class=\"tab-content\" id=\"myTabContent\">\n                <!-- RA Tab -->\n                <div class=\"tab-pane fade show active\" id=\"RA\" role=\"tabpanel\" aria-labelledby=\"ra-tab\">\n                    <div class=\"dosing-notes\">\n                        <span style=\"font-size: inherit\"><strong>Rheumatoid Arthritis (RA; adult patients)<\/strong><\/span>\r\n\r\n&nbsp;\r\n<ul>\r\n \t<li>TOFIDENCE may be used as monotherapy or concomitantly with methotrexate or other non-biologic DMARDs as an intravenous infusion.<\/li>\r\n \t<li>Recommended starting dosage is 4 mg\/kg every 4 weeks followed by an increase to 8 mg\/kg every 4 weeks based on clinical response.<\/li>\r\n<\/ul>                    <\/div>\n                    <div class=\"dosing-input-and-output\">\n                        <div class=\"dosing-input-wrapper\">\n                            <form action=\"#\" id=\"ra-form\">\n                                <div class=\"input-form-field\">\n                                    <label for=\"ra-weight-input\">Enter patient weight (kg)<\/label>\n                                    <div class=\"input-form-fieldinner\">\n                                        <input type=\"text\" class=\"form-control\" id=\"ra-weight-input\" placeholder=\"Enter weight\">\n                                        <div id=\"ra-weight-validation\" class=\"validation-message\"><\/div>\n                                    <\/div>\n                                <\/div>\n                                <label>Select one of the following:<\/label>\n                                <div class=\"form-check\">\n                                    <input class=\"form-check-input\" type=\"radio\" name=\"ra-select-dose\" id=\"RA4mg\" value=\"4\">\n                                    <label class=\"form-check-label\" for=\"RA4mg\">4 mg\/kg<\/label>\n                                <\/div>\n                                <div class=\"form-check\">\n                                    <input class=\"form-check-input\" type=\"radio\" name=\"ra-select-dose\" id=\"RA8mg\" value=\"8\">\n                                    <label class=\"form-check-label\" for=\"RA8mg\">8 mg\/kg<\/label>\n                                <\/div>\n                                <div class=\"submit-dosing-inputs\">\n                                    <button type=\"button\" class=\"btn btn-theme\" id=\"ra-calculate-btn\" disabled>Calculate Dosage Option<\/button>\n                                    <button type=\"button\" class=\"btn btn-outline\" id=\"ra-clear-btn\" disabled>Clear<\/button>\n                                <\/div>\n                                                                    <p>In RA, doses exceeding 800 mg per infusion are not recommended.<\/p>\n                                                            <\/form>\n                        <\/div>\n                        <div class=\"dosing-output-wrapper\">\n                            <div class=\"dose-result\" id=\"ra-result-section\">\n                                <div class=\"initial-text\">\n                                    <p>Complete the form to view dosing information.<\/p>\n                                <\/div>\n                            <\/div>\n                        <\/div>\n                    <\/div>\n                <\/div>\n\n                <!-- GCA Tab -->\n                <div class=\"tab-pane fade\" id=\"GCA\" role=\"tabpanel\" aria-labelledby=\"gca-tab\">\n                    <div class=\"dosing-notes\">\n                        <span style=\"font-size: inherit\"><strong>Giant Cell Arteritis (GCA; adult patients)<\/strong><\/span>\r\n\r\n&nbsp;\r\n<ul>\r\n \t<li>The recommended dosage of TOFIDENCE for adult patients given as a 60-minute single intravenous drip infusion is 6 mg per kg every 4 weeks in combination with tapering course of glucocorticoids.\r\n<ul>\r\n \t<li>TOFIDENCE can be used alone following discontinuation of glucocorticoids.<\/li>\r\n \t<li>Doses exceeding 600 mg per infusion are not recommended in GCA patients.<\/li>\r\n<\/ul>\r\n<\/li>\r\n<\/ul>                    <\/div>\n                    <div class=\"dosing-input-and-output\">\n                        <div class=\"dosing-input-wrapper\">\n                            <form action=\"#\" id=\"gca-form\">\n                                <div class=\"input-form-field\">\n                                    <label for=\"gca-weight-input\">Enter patient weight (kg)<\/label>\n                                    <div class=\"input-form-fieldinner\">\n                                        <input type=\"text\" class=\"form-control\" id=\"gca-weight-input\" placeholder=\"Enter weight\">\n                                        <div id=\"gca-weight-validation\" class=\"validation-message\"><\/div>\n                                    <\/div>\n                                <\/div>\n                                <p>Recommended dosage: 6 mg\/kg<\/p>\n                                <div class=\"submit-dosing-inputs\">\n                                    <button type=\"button\" class=\"btn btn-theme\" id=\"gca-calculate-btn\" disabled>Calculate Dosage Option<\/button>\n                                    <button type=\"button\" class=\"btn btn-outline\" id=\"gca-clear-btn\" disabled>Clear<\/button>\n                                <\/div>\n                                                                    <p>In GCA, doses exceeding 600 mg per infusion are not recommended.<\/p>\n                                                            <\/form>\n                        <\/div>\n                        <div class=\"dosing-output-wrapper\">\n                            <div class=\"dose-result\" id=\"gca-result-section\">\n                                <div class=\"initial-text\">\n                                    <p>Complete the form to view dosing information.<\/p>\n                                <\/div>\n                            <\/div>\n                        <\/div>\n                    <\/div>\n                <\/div>\n\n                <!-- PJIA Tab -->\n                <div class=\"tab-pane fade\" id=\"PJIA\" role=\"tabpanel\" aria-labelledby=\"pjia-tab\">\n                    <div class=\"dosing-notes\">\n                        <span style=\"font-size: inherit\"><strong>Polyarticular Juvenile Idiopathic Arthritis (PJIA; patients aged 2 years and older)<\/strong><\/span>\r\n\r\n&nbsp;\r\n<ul>\r\n \t<li>TOFIDENCE may be used as an intravenous infusion alone or in combination with methotrexate. Do not change dose based solely on a single-visit body-weight measurement, as weight may fluctuate.<\/li>\r\n \t<li>Recommended dosing every 4 weeks:\r\n<ul>\r\n \t<li>Patients &lt;30 kg: 10 mg\/kg<\/li>\r\n \t<li>Patients \u226530 kg: 8 mg\/kg<\/li>\r\n<\/ul>\r\n<\/li>\r\n<\/ul>                    <\/div>\n                    <div class=\"dosing-input-and-output\">\n                        <div class=\"dosing-input-wrapper\">\n                            <form action=\"#\" id=\"pjia-form\">\n                                <div class=\"input-form-field\">\n                                    <label for=\"pjia-weight-input\">Enter patient weight (kg)<\/label>\n                                    <div class=\"input-form-fieldinner\">\n                                        <input type=\"text\" class=\"form-control\" id=\"pjia-weight-input\" placeholder=\"Enter weight\">\n                                        <div id=\"pjia-weight-validation\" class=\"validation-message\"><\/div>\n                                    <\/div>\n                                <\/div>\n                                <div class=\"submit-dosing-inputs\">\n                                    <button type=\"button\" class=\"btn btn-theme\" id=\"pjia-calculate-btn\" disabled>Calculate Dosage Option<\/button>\n                                    <button type=\"button\" class=\"btn btn-outline\" id=\"pjia-clear-btn\" disabled>Clear<\/button>\n                                <\/div>\n                                                            <\/form>\n                        <\/div>\n                        <div class=\"dosing-output-wrapper\">\n                            <div class=\"dose-result\" id=\"pjia-result-section\">\n                                <div class=\"initial-text\">\n                                    <p>Complete the form to view dosing information.<\/p>\n                                <\/div>\n                            <\/div>\n                        <\/div>\n                    <\/div>\n                <\/div>\n\n                <!-- SJIA Tab -->\n                <div class=\"tab-pane fade\" id=\"SJIA\" role=\"tabpanel\" aria-labelledby=\"sjia-tab\">\n                    <div class=\"dosing-notes\">\n                        <span style=\"font-size: inherit\"><strong>Systemic Juvenile Idiopathic Arthritis (SJIA; patients aged 2 years and older)<\/strong><\/span>\r\n\r\n&nbsp;\r\n<ul>\r\n \t<li>TOFIDENCE may be used as an intravenous infusion or in combination with methotrexate. Do not change a dose based solely on a single-visit body-weight measurement, as weight may fluctuate.<\/li>\r\n \t<li>Recommended dosing every 2 weeks:\r\n<ul>\r\n \t<li>Patients &lt;30 kg: 12 mg\/kg<\/li>\r\n \t<li>Patients \u226530 kg: 8 mg\/kg<\/li>\r\n<\/ul>\r\n<\/li>\r\n<\/ul>                    <\/div>\n                    <div class=\"dosing-input-and-output\">\n                        <div class=\"dosing-input-wrapper\">\n                            <form action=\"#\" id=\"sjia-form\">\n                                <div class=\"input-form-field\">\n                                    <label for=\"sjia-weight-input\">Enter patient weight (kg)<\/label>\n                                    <div class=\"input-form-fieldinner\">\n                                        <input type=\"text\" class=\"form-control\" id=\"sjia-weight-input\" placeholder=\"Enter weight\">\n                                        <div id=\"sjia-weight-validation\" class=\"validation-message\"><\/div>\n                                    <\/div>\n                                <\/div>\n                                <div class=\"submit-dosing-inputs\">\n                                    <button type=\"button\" class=\"btn btn-theme\" id=\"sjia-calculate-btn\" disabled>Calculate Dosage Option<\/button>\n                                    <button type=\"button\" class=\"btn btn-outline\" id=\"sjia-clear-btn\" disabled>Clear<\/button>\n                                <\/div>\n                                                            <\/form>\n                        <\/div>\n                        <div class=\"dosing-output-wrapper\">\n                            <div class=\"dose-result\" id=\"sjia-result-section\">\n                                <div class=\"initial-text\">\n                                    <p>Complete the form to view dosing information.<\/p>\n                                <\/div>\n                            <\/div>\n                        <\/div>\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-color has-link-color wp-elements-636c72d7df31560ad281e10777b2cbd0 wp-block-paragraph\" style=\"color:#171717;font-size:15px\">By using this resource, you agree to the following: This Dosing Calculator is being provided \u201cAS IS\u201d and is intended for use only by qualified healthcare providers. All calculations should be confirmed before use. Organon makes no claims as to the accuracy of the information contained herein. The information being provided is not a substitute for, and should not replace, independent clinical judgment and medical examinations. Neither Organon, nor any other party involved in the preparation or publication of this site, shall be liable to you or others for any decisions made or actions taken by you or others in reliance on this information.<br><br>TOFIDENCE should not be infused concomitantly in the same intravenous line with other drugs. No physical or biochemical compatibility studies have been conducted to evaluate the co-administration of TOFIDENCE with other drugs. The infusion should be administered over 60 minutes and must be administered with an infusion set. Do not administer as an intravenous push or bolus. For additional information, please refer to the <a style=\"color:#809D15;text-decoration: underline\" href=\"https:\/\/www.organon.com\/product\/usa\/pi_circulars\/t\/tofidence\/Tofidence_PI.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Prescribing Information<\/a>.<\/p>\n\n\n\n<div style=\"height:64px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:25%\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"350\" height=\"350\" src=\"https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2026\/07\/resource_patients_practice.png?w=350\" alt=\"Man in green shirt and khaki pants walking up bleachers with people seated in the background\" class=\"wp-image-11093\" srcset=\"https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2026\/07\/resource_patients_practice.png 350w, https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2026\/07\/resource_patients_practice.png?resize=150,150 150w, https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2026\/07\/resource_patients_practice.png?resize=300,300 300w, https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2026\/07\/resource_patients_practice.png?resize=126,126 126w, https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2026\/07\/resource_patients_practice.png?resize=260,260 260w, https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2026\/07\/resource_patients_practice.png?resize=268,268 268w, https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2026\/07\/resource_patients_practice.png?resize=223,223 223w, https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2026\/07\/resource_patients_practice.png?resize=100,100 100w, https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2026\/07\/resource_patients_practice.png?resize=158,158 158w, https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2026\/07\/resource_patients_practice.png?resize=64,64 64w, https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2026\/07\/resource_patients_practice.png?resize=346,346 346w, https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2026\/07\/resource_patients_practice.png?resize=80,80 80w, https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2026\/07\/resource_patients_practice.png?resize=97,97 97w, https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2026\/07\/resource_patients_practice.png?resize=125,125 125w, https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2026\/07\/resource_patients_practice.png?resize=250,250 250w, https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2026\/07\/resource_patients_practice.png?resize=313,313 313w, https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2026\/07\/resource_patients_practice.png?resize=200,200 200w\" sizes=\"auto, (max-width: 350px) 100vw, 350px\" \/><figcaption class=\"wp-element-caption\"><em>AI-generated imagery.<\/em><\/figcaption><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:75%\">\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 id=\"h-resources-for-your-patients-and-practice\" class=\"wp-block-heading has-black-color has-text-color has-link-color wp-elements-83e8e3daf3a27586fa3b4ba14b235b88\">Resources for your patients and practice<\/h3>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color wp-elements-ceab978ff9ac5d66980f717759598f67 wp-block-paragraph\">Learn about our access program and other tools to support treatment with TOFIDENCE.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-white-color has-text-color has-background has-link-color has-custom-font-size wp-element-button\" href=\"https:\/\/organonpro.com\/en-us\/product\/tofidence\/professional-resources\/\" style=\"background-color:#809d15;font-size:16px\">Go to professional resources<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:36px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"author":116,"featured_media":0,"parent":9756,"menu_order":4,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"product_categories":[],"product_specialization":[],"customer_type":[],"class_list":["post-11092","product","type-product","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.7 (Yoast SEO v27.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>TOFIDENCE\u00ae (tocilizumab-bavi) Injection 20 mg\/mL Dosage Calculator<\/title>\n<meta name=\"description\" content=\"Use this calculator to determine dosage of TOFIDENCE\u00ae (tocilizumab-bavi) injection 20 mg\/mL based on patient weight across approved indications\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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patient weight across approved indications","og_url":"https:\/\/organonpro.com\/en-us\/product\/tofidence\/dosing-calculator\/","og_site_name":"US","article_modified_time":"2026-07-15T12:08:45+00:00","og_image":[{"width":350,"height":350,"url":"https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2026\/07\/resource_patients_practice.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/organonpro.com\/en-us\/product\/tofidence\/dosing-calculator\/","url":"https:\/\/organonpro.com\/en-us\/product\/tofidence\/dosing-calculator\/","name":"TOFIDENCE\u00ae (tocilizumab-bavi) Injection 20 mg\/mL Dosage 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