{"id":10411,"date":"2026-01-12T03:39:13","date_gmt":"2026-01-12T03:39:13","guid":{"rendered":"https:\/\/organonpro.com\/en-us\/product\/dosing-calculator\/"},"modified":"2026-01-14T12:29:48","modified_gmt":"2026-01-14T12:29:48","slug":"dosing-calculator","status":"publish","type":"product","link":"https:\/\/organonpro.com\/en-us\/product\/tofidence\/dosing-calculator\/","title":{"rendered":"Dosing Calculator"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\">TOFIDENCE IV Infusion Dosing Calculator<\/h1>\n\n\n\n<h3 class=\"wp-block-heading seo-heading-two-title\" id=\"h-renflexis-same-dosing-as-remicade-infliximab\">The dosing calculator below can be used to determine TOFIDENCE IV infusion dosing based on individual patient weight.<\/h3>\n\n\n\n<p><\/p>\n\n\n\n<p><span style=\"text-decoration: underline;\">Not Recommended for Concomitant Use with Biological <span style=\"text-decoration: underline;\">Disease-Modifying Antirheumatic Drugs (DMARDs)<\/span><\/span><br>Tocilizumab products have not been studied in combination with biological DMARDs such as tumor necrosis factor (TNF) antagonists, interleukin-1 receptor (IL-1R) antagonists, anti-CD20 monoclonal antibodies, and selective co-stimulation modulators because of the possibility of increased immunosuppression and increased risk of infection. Avoid using TOFIDENCE with biological DMARDs.<br><br>Please see Prescribing Information for laboratory testing needed prior to treatment with TOFIDENCE.<\/p>\n\n\n\n<p><strong>Start by selecting the appropriate indication on the tabs below<\/strong>.<\/p>\n\n\n\n        <div class=\"dosing-calculator\">\n            <ul class=\"nav nav-tabs nav-justified\" id=\"myTab\" role=\"tablist\">\n                <li class=\"nav-item\" role=\"presentation\">\n                    <button class=\"nav-link active\" id=\"ra-tab\" data-bs-toggle=\"tab\" data-bs-target=\"#RA\" type=\"button\" role=\"tab\" aria-controls=\"ra\" aria-selected=\"true\">RA<\/button>\n                <\/li>\n                <li class=\"nav-item\" role=\"presentation\">\n                    <button class=\"nav-link\" id=\"gca-tab\" data-bs-toggle=\"tab\" data-bs-target=\"#GCA\" type=\"button\" role=\"tab\" aria-controls=\"gca\" aria-selected=\"false\">GCA<\/button>\n                <\/li>\n                <li class=\"nav-item\" role=\"presentation\">\n                    <button class=\"nav-link\" id=\"pjia-tab\" data-bs-toggle=\"tab\" data-bs-target=\"#PJIA\" type=\"button\" role=\"tab\" aria-controls=\"pjia\" aria-selected=\"false\">PJIA<\/button>\n                <\/li>\n                <li class=\"nav-item\" role=\"presentation\">\n                    <button class=\"nav-link\" id=\"sjia-tab\" data-bs-toggle=\"tab\" data-bs-target=\"#SJIA\" type=\"button\" role=\"tab\" aria-controls=\"sjia\" aria-selected=\"false\">SJIA<\/button>\n                <\/li>\n            <\/ul>\n            <div class=\"tab-content\" id=\"myTabContent\">\n                <!-- RA Tab -->\n                <div class=\"tab-pane fade show active\" id=\"RA\" role=\"tabpanel\" aria-labelledby=\"ra-tab\">\n                    <div class=\"dosing-notes\">\n                        <span style=\"font-size: inherit\"><strong>Rheumatoid Arthritis (RA; adult patients)<\/strong><\/span>\r\n\r\n&nbsp;\r\n<ul>\r\n \t<li>TOFIDENCE may be used as monotherapy or concomitantly with methotrexate or other non-biologic DMARDs as an intravenous infusion.<\/li>\r\n \t<li>Recommended starting dosage is 4 mg\/kg every 4 weeks followed by an increase to 8 mg\/kg every 4 weeks based on clinical response.<\/li>\r\n<\/ul>                    <\/div>\n                    <div class=\"dosing-input-and-output\">\n                        <div class=\"dosing-input-wrapper\">\n                            <form action=\"#\" id=\"ra-form\">\n                                <div class=\"input-form-field\">\n                                    <label for=\"ra-weight-input\">Enter patient weight (kg)<\/label>\n                                    <div class=\"input-form-fieldinner\">\n                                        <input type=\"text\" class=\"form-control\" id=\"ra-weight-input\" placeholder=\"Enter weight\">\n                                        <div id=\"ra-weight-validation\" class=\"validation-message\"><\/div>\n                                    <\/div>\n                                <\/div>\n                                <label>Select one of the following:<\/label>\n                                <div class=\"form-check\">\n                                    <input class=\"form-check-input\" type=\"radio\" name=\"ra-select-dose\" id=\"RA4mg\" value=\"4\">\n                                    <label class=\"form-check-label\" for=\"RA4mg\">4 mg\/kg<\/label>\n                                <\/div>\n                                <div class=\"form-check\">\n                                    <input class=\"form-check-input\" type=\"radio\" name=\"ra-select-dose\" id=\"RA8mg\" value=\"8\">\n                                    <label class=\"form-check-label\" for=\"RA8mg\">8 mg\/kg<\/label>\n                                <\/div>\n                                <div class=\"submit-dosing-inputs\">\n                                    <button type=\"button\" class=\"btn btn-theme\" id=\"ra-calculate-btn\" disabled>Calculate Dosage Option<\/button>\n                                    <button type=\"button\" class=\"btn btn-outline\" id=\"ra-clear-btn\" disabled>Clear<\/button>\n                                <\/div>\n                                                                    <p>In RA, doses exceeding 800 mg per infusion are not recommended.<\/p>\n                                                            <\/form>\n                        <\/div>\n                        <div class=\"dosing-output-wrapper\">\n                            <div class=\"dose-result\" id=\"ra-result-section\">\n                                <div class=\"initial-text\">\n                                    <p>Complete the form to view dosing information.<\/p>\n                                <\/div>\n                            <\/div>\n                        <\/div>\n                    <\/div>\n                <\/div>\n\n                <!-- GCA Tab -->\n                <div class=\"tab-pane fade\" id=\"GCA\" role=\"tabpanel\" aria-labelledby=\"gca-tab\">\n                    <div class=\"dosing-notes\">\n                        <span style=\"font-size: inherit\"><strong>Giant Cell Arteritis (GCA; adult patients)<\/strong><\/span>\r\n\r\n&nbsp;\r\n<ul>\r\n \t<li>The recommended dosage of TOFIDENCE for adult patients given as a 60-minute single intravenous drip infusion is 6 mg per kg every 4 weeks in combination with tapering course of glucocorticoids.\r\n<ul>\r\n \t<li>TOFIDENCE can be used alone following discontinuation of glucocorticoids.<\/li>\r\n \t<li>Doses exceeding 600 mg per infusion are not recommended in GCA patients.<\/li>\r\n<\/ul>\r\n<\/li>\r\n<\/ul>                    <\/div>\n                    <div class=\"dosing-input-and-output\">\n                        <div class=\"dosing-input-wrapper\">\n                            <form action=\"#\" id=\"gca-form\">\n                                <div class=\"input-form-field\">\n                                    <label for=\"gca-weight-input\">Enter patient weight (kg)<\/label>\n                                    <div class=\"input-form-fieldinner\">\n                                        <input type=\"text\" class=\"form-control\" id=\"gca-weight-input\" placeholder=\"Enter weight\">\n                                        <div id=\"gca-weight-validation\" class=\"validation-message\"><\/div>\n                                    <\/div>\n                                <\/div>\n                                <p>Recommended dosage: 6 mg\/kg<\/p>\n                                <div class=\"submit-dosing-inputs\">\n                                    <button type=\"button\" class=\"btn btn-theme\" id=\"gca-calculate-btn\" disabled>Calculate Dosage Option<\/button>\n                                    <button type=\"button\" class=\"btn btn-outline\" id=\"gca-clear-btn\" disabled>Clear<\/button>\n                                <\/div>\n                                                                    <p>In GCA, doses exceeding 600 mg per infusion are not recommended.<\/p>\n                                                            <\/form>\n                        <\/div>\n                        <div class=\"dosing-output-wrapper\">\n                            <div class=\"dose-result\" id=\"gca-result-section\">\n                                <div class=\"initial-text\">\n                                    <p>Complete the form to view dosing information.<\/p>\n                                <\/div>\n                            <\/div>\n                        <\/div>\n                    <\/div>\n                <\/div>\n\n                <!-- PJIA Tab -->\n                <div class=\"tab-pane fade\" id=\"PJIA\" role=\"tabpanel\" aria-labelledby=\"pjia-tab\">\n                    <div class=\"dosing-notes\">\n                        <span style=\"font-size: inherit\"><strong>Polyarticular Juvenile Idiopathic Arthritis (PJIA; patients aged 2 years and older)<\/strong><\/span>\r\n\r\n&nbsp;\r\n<ul>\r\n \t<li>TOFIDENCE may be used as an intravenous infusion alone or in combination with methotrexate. Do not change dose based solely on a single-visit body-weight measurement, as weight may fluctuate.<\/li>\r\n \t<li>Recommended dosing every 4 weeks:\r\n<ul>\r\n \t<li>Patients &lt;30 kg: 10 mg\/kg<\/li>\r\n \t<li>Patients \u226530 kg: 8 mg\/kg<\/li>\r\n<\/ul>\r\n<\/li>\r\n<\/ul>                    <\/div>\n                    <div class=\"dosing-input-and-output\">\n                        <div class=\"dosing-input-wrapper\">\n                            <form action=\"#\" id=\"pjia-form\">\n                                <div class=\"input-form-field\">\n                                    <label for=\"pjia-weight-input\">Enter patient weight (kg)<\/label>\n                                    <div class=\"input-form-fieldinner\">\n                                        <input type=\"text\" class=\"form-control\" id=\"pjia-weight-input\" placeholder=\"Enter weight\">\n                                        <div id=\"pjia-weight-validation\" class=\"validation-message\"><\/div>\n                                    <\/div>\n                                <\/div>\n                                <div class=\"submit-dosing-inputs\">\n                                    <button type=\"button\" class=\"btn btn-theme\" id=\"pjia-calculate-btn\" disabled>Calculate Dosage Option<\/button>\n                                    <button type=\"button\" class=\"btn btn-outline\" id=\"pjia-clear-btn\" disabled>Clear<\/button>\n                                <\/div>\n                                                            <\/form>\n                        <\/div>\n                        <div class=\"dosing-output-wrapper\">\n                            <div class=\"dose-result\" id=\"pjia-result-section\">\n                                <div class=\"initial-text\">\n                                    <p>Complete the form to view dosing information.<\/p>\n                                <\/div>\n                            <\/div>\n                        <\/div>\n                    <\/div>\n                <\/div>\n\n                <!-- SJIA Tab -->\n                <div class=\"tab-pane fade\" id=\"SJIA\" role=\"tabpanel\" aria-labelledby=\"sjia-tab\">\n                    <div class=\"dosing-notes\">\n                        <span style=\"font-size: inherit\"><strong>Systemic Juvenile Idiopathic Arthritis (SJIA; patients aged 2 years and older)<\/strong><\/span>\r\n\r\n&nbsp;\r\n<ul>\r\n \t<li>TOFIDENCE may be used as an intravenous infusion or in combination with methotrexate. Do not change a dose based solely on a single-visit body-weight measurement, as weight may fluctuate.<\/li>\r\n \t<li>Recommended dosing every 2 weeks:\r\n<ul>\r\n \t<li>Patients &lt;30 kg: 12 mg\/kg<\/li>\r\n \t<li>Patients \u226530 kg: 8 mg\/kg<\/li>\r\n<\/ul>\r\n<\/li>\r\n<\/ul>                    <\/div>\n                    <div class=\"dosing-input-and-output\">\n                        <div class=\"dosing-input-wrapper\">\n                            <form action=\"#\" id=\"sjia-form\">\n                                <div class=\"input-form-field\">\n                                    <label for=\"sjia-weight-input\">Enter patient weight (kg)<\/label>\n                                    <div class=\"input-form-fieldinner\">\n                                        <input type=\"text\" class=\"form-control\" id=\"sjia-weight-input\" placeholder=\"Enter weight\">\n                                        <div id=\"sjia-weight-validation\" class=\"validation-message\"><\/div>\n                                    <\/div>\n                                <\/div>\n                                <div class=\"submit-dosing-inputs\">\n                                    <button type=\"button\" class=\"btn btn-theme\" id=\"sjia-calculate-btn\" disabled>Calculate Dosage Option<\/button>\n                                    <button type=\"button\" class=\"btn btn-outline\" id=\"sjia-clear-btn\" disabled>Clear<\/button>\n                                <\/div>\n                                                            <\/form>\n                        <\/div>\n                        <div class=\"dosing-output-wrapper\">\n                            <div class=\"dose-result\" id=\"sjia-result-section\">\n                                <div class=\"initial-text\">\n                                    <p>Complete the form to view dosing information.<\/p>\n                                <\/div>\n                            <\/div>\n                        <\/div>\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n\n\n\n\n<p>By using this resource, you agree to the following: This Dosing Calculator is being provided \u201cAS IS\u201d and is intended for use only by qualified healthcare providers. All calculations should be confirmed before use. Organon makes no claims as to the accuracy of the information contained herein. The information being provided is not a substitute for, and should not replace, independent clinical judgment and medical examinations. Neither Organon, nor any other party involved in the preparation or publication of this site, shall be liable to you or others for any decisions made or actions taken by you or others in reliance on this information.<br><br>TOFIDENCE should not be infused concomitantly in the same intravenous line with other drugs. No physical or biochemical compatibility studies have been conducted to evaluate the co-administration of TOFIDENCE with other drugs. The infusion should be administered over 60 minutes and must be administered with an infusion set. Do not administer as an intravenous push or bolus. For additional information, please refer to the <a href=\"https:\/\/www.organon.com\/product\/usa\/pi_circulars\/t\/tofidence\/Tofidence_PI.pdf\"><span style=\"text-decoration: underline;\"><strong>Prescribing Information<\/strong><\/span><\/a>.<\/p>\n","protected":false},"author":116,"featured_media":0,"parent":9756,"menu_order":2,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"product_categories":[],"product_specialization":[],"customer_type":[],"class_list":["post-10411","product","type-product","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.11 (Yoast SEO v26.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>TOFIDENCE\u00ae (tocilizumab-bavi) Injection 20 mg\/mL Dosage Calculator<\/title>\n<meta name=\"description\" content=\"Use this calculator to determine dosage of TOFIDENCE\u00ae (tocilizumab-bavi) injection 20 mg\/mL based on 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