{"id":10300,"date":"2025-08-18T17:31:53","date_gmt":"2025-08-18T17:31:53","guid":{"rendered":"https:\/\/organonpro.com\/en-us\/product\/bilprevda-2\/understanding-sres\/"},"modified":"2026-02-18T15:16:19","modified_gmt":"2026-02-18T15:16:19","slug":"understanding-sres","status":"publish","type":"product","link":"https:\/\/organonpro.com\/en-us\/product\/bilprevda\/understanding-sres\/","title":{"rendered":"Understanding SREs"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\">Understanding the risk of skeletal-related events<\/h1>\n\n\n\n<p>Patients with metastatic cancer face a higher risk of skeletal-related events (SREs), such as pathologic fractures, spinal cord compression, and the need for radiation or surgery to bone. Educating them about these risks and the role of bone-targeting agents in reducing SREs can help reinforce the importance of treatment.<sup>1,6<\/sup><\/p>\n\n\n\n<div style=\"height:35px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" src=\"https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2025\/08\/skeleton.png\" alt=\"\"\/><\/figure><\/div>\n\n\n<p class=\"has-text-align-center\">The skeleton is the third most common site of metastatic disease after the lungs and liver<sup>1<\/sup><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:10%\"><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" src=\"https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2025\/08\/calendar_icon.png\" alt=\"\"\/><\/figure><\/div>\n\n\n<p class=\"has-text-align-center\">On average, a patient with metastatic disease spreading to the bone may experience an SRE every 3 to 6 months throughout their experience with the disease<sup>8<\/sup><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:10%\"><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" src=\"https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2025\/08\/stopwatch_icon.png\" alt=\"\"\/><\/figure><\/div>\n\n\n<p class=\"has-text-align-center\">It is important to identify bone metastasis early for staging and prognosis, as well as implementing prophylactic and treatment strategies that may reduce morbidity and mortality<sup>1<\/sup><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:10%\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:35px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>In cancer-induced osteolytic bone metastases, a vicious cycle emerges between tumors and osteoclasts. Osteoclastic bone resorption releases growth factors that enhance the formation of osteoclasts, which then resorb bone and, in the process, release additional growth factors that further promote tumor growth.<sup>9<\/sup><\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" src=\"https:\/\/organonpro.com\/en-us\/wp-content\/uploads\/sites\/6\/2025\/08\/standing.png\" alt=\"Man in patterned tuxedo jacket with arm bone x-ray overlay\u2014upper-limb bone health illustration on a white background.\"\/><\/figure><\/div><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h2 class=\"wp-block-heading\">Explore a clinical summary of BILPREVDA<\/h2>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-white-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/organonpro.com\/en-us\/product\/bilprevda\/why-bilprevda\/#biosimilar\" style=\"background-color:#d53179\">Take a closer look<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-small-font-size\">Computer-generated X-ray depiction of humerus represents one of the common sites of bone metastases.<sup>1<\/sup><\/p>\n","protected":false},"author":65,"featured_media":0,"parent":10297,"menu_order":3,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"product_categories":[],"product_specialization":[],"customer_type":[],"class_list":["post-10300","product","type-product","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.11 (Yoast SEO v26.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>BILPREVDA\u00ae (denosumab-nxxp) | Understanding SREs<\/title>\n<meta name=\"description\" content=\"Learn more about the condition of skeletal-related events (SREs)\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/organonpro.com\/en-us\/product\/bilprevda\/understanding-sres\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" 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