How to insert, remove, and replace Nexplanon*

The Nexplanon Training Support Programme (NTSP) Nurse Team are delighted to provide you with guides on how to insert, remove, and replace Nexplanon.*

NTSP is fully funded by Organon and part of the Risk Minimisation Measures for Nexplanon.

How to insert Nexplanon1

Pregnancy should be excluded before insertion of Nexplanon. The implant should be inserted subdermally just under the skin. If the implant is not inserted in accordance with the instructions and not on the correct day, this may result in an unintended pregnancy.

  • The basis for successful use and subsequent removal of the Nexplanon implant is a correct and carefully performed subdermal insertion of the implant in accordance with the instructions
  • Deep or incorrect insertions have been associated with paraesthesia (due to neural damage) and migration of the implant (due to intramuscular or fascial insertion, and in rare cases with intravascular insertion, including rare cases of migration to the chest wall
  • Always verify the presence of the implant in the woman’s arm immediately after insertion by palpation
  • Find out what to do if the implant is not palpable

Refer to the Summary of Product Characteristics for guidance on when to insert Nexplanon and further information regarding complications of insertion.

Insertion of Nexplanon should be performed under aseptic conditions and only by a qualified Healthcare Professional (HCP) who has completed training for the insertion and removal of the Nexplanon implant. Insertion of the implant should only be performed with the preloaded applicator.

How to remove Nexplanon1

Removal of the implant should only be performed under aseptic conditions by an HCP who is familiar with the removal technique. If you are unfamiliar with the removal technique, contact the Marketing Authorisation Holder for more information.**

Before initiating the removal procedure, the HCP should assess the location of the implant. Verify the exact location of the implant in the arm by palpation.

How to replace Nexplanon1

Immediate replacement can be done after removal of the previous implant and is similar to the insertion procedure described in the section ‘How to insert Nexplanon’.

  • The new implant may be inserted in the same arm, and through the same incision from which the previous implant was removed as long as the site is in the correct location, i.e. 8-10 cm from the medial epicondyle of the humerus and 3-5 cm posterior to (below) the sulcus
  • If the same incision is being used to insert a new implant, anaesthetise the insertion site by injecting an anaesthetic (e.g. 2 mL lidocaine (1%)) just under the skin commencing at the removal incision along the ‘insertion canal’ and follow the subsequent steps in the insertion instructions

Not yet trained to fit Nexplanon? Find out how to

For further information about the program and to start your NTSP training journey please contact our dedicated nurse team at:

*This site provides information regarding the insertion and removal of Nexplanon, implant for subdermal use. It is strongly recommended that Nexplanon be inserted and removed only by healthcare professionals who have completed training for the use of the Nexplanon applicator and the techniques for insertion and removal of the Nexplanon implant, and, where appropriate, that supervision be requested prior to inserting or removing the implant. It is not intended to serve as a substitute for face-to-face training. Please always refer to the information within the Summary of Product Characteristics.

**You can contact the Marketing Authorisation Holder, Organon, by: telephone – 02081 593593; email –


  1. Nexplanon Summary of Product Characteristics
GB-XPL-115397 | Date of Preparation December 2022